🇦🇺Australia

Lancôme Advanced Génifique Night Cream for acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Lancôme Advanced Génifique Night Cream

Average

  • AverageCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for acne-prone skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate suitability for combination skin as Bifida Ferment Lysate and Sodium Hyaluronate provide barrier repair and hydration, though it may lack sufficient ingredients for optimal oil control.
  • The presence of Glycerin and Sodium Hyaluronate offers general skincare benefits, such as hydration and soothing, which are supportive for acne-prone skin.
  • There are no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

How to apply

  • Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
  • Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
  • Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
  • Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
  • Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.

People Say

★4.7Overall rating based on 2.7k+ reviews

Based on a very large amount of data, this product is highly regarded for its ability to deeply hydrate dry and aging skin, effectively repair the moisture barrier, and leave the complexion feeling plump, smooth, and radiant by morning. It is frequently noted for reducing the appearance of fine lines and smoothing the skin texture. While most users find it absorbs quickly without a greasy feel, a small number of individuals with sensitive skin have reported experiencing breakouts or irritation, and some dislike the fragrance.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “The product provides deep hydration and visible rejuvenation.”
    • “Skin feels softer, smoother, and more hydrated.”
    • “Leaves skin moisturized and glowing.”
    • “Thick and moisturizing.”
  • Absorbs quickly Often Mentioned
    • “Doesn't have an oil feeling it's very light.”
    • “Absorbs quickly and leaves skin feeling refreshed without feeling greasy.”
    • “Thicker cream that does not make face feel greasy.”
    • “Does not leave the skin feeling sticky.”
  • Softens and smooths Often Mentioned
    • “Face is so soft, smooth and not puffy.”
    • “Goes on smoothly and makes skin feel like butter.”
    • “Skin feels softer, smoother, and more hydrated.”
    • “Leaves the skin feeling softer, smoother, and more radiant.”
  • Reduces fine lines Sometimes Noted
    • “Helps with wrinkles and makes skin soft.”
    • “Noticed a difference with the crows feet around my eyes.”
    • “Helps reduce the appearance of fine lines and wrinkles.”
    • “Reduces the appearance of fine lines and wrinkles, to leave skin looking youthful.”
  • Causes breakouts Rarely Noted
    • “Caused swelling and breakouts.”
    • “Had a few pimples that I didn't have before.”
    • “Did have one pimple below my eye.”
    • “Tiny pimples (bumps) on my jaw line and above my brows.”
  • Skin irritation Rarely Noted
    • “Started burning my face.”
    • “Smells very bad and itchy.”
    • “Caused swelling and breakouts.”
    • “Afraid to use it because it made me wonder what is in it.”
  • Unpleasant smell Rarely Noted
    • “Smells terrible, similar to hair bleach.”
    • “Smells like old sunscreen.”
    • “Smells very bad.”
    • “Disliked the fragrance.”

Sources: lovi.care, macys.com, lookfantastic.com, ulta.com, lancome-usa.com, nordstromrack.com, and more

Questions and answers

How well does Lancôme Advanced Génifique Night Cream work for acne-prone skin?

This cream works moderately well for acne-prone skin because it provides helpful hydration and soothing benefits, though it may lack sufficient ingredients for optimal oil control. To work best for this skin type, a product of this type needs targeted ingredients for blemishes and oil control alongside soothing agents.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for acne-prone skin?

Glycerin and sodium hyaluronate make this cream a good fit for acne-prone skin by providing gentle hydration and soothing benefits. However, a product of this type needs targeted ingredients for oil control and blemishes to achieve an ideal fit for this skin.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Bifida Ferment Lysate do for acne-prone skin?

Bifida Ferment Lysate helps acne-prone skin by calming redness and keeping the skin barrier strong. This ingredient may also support the skin's defenses against irritation, making it less likely to flare up.

Journal of Cosmetic Dermatology, 2023Experimental Dermatology, 2010

What does Adenosine do for acne-prone skin?

Adenosine helps calm acne-prone skin by reducing redness and swelling. It is unlikely to clear breakouts on its own, so acne-prone skin needs ingredients that clear pores and balance oil, like salicylic acid.

Experimental Dermatology, 2014

Where does this cream go in a skincare routine for acne-prone skin?

This cream works as a moisturizing treatment in your evening routine, though other products fit acne-prone skin better. To better suit this skin, a product of this type needs added oil-control ingredients.

Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first, letting it absorb, and then following with this moisturizer. This helps keep your skin soft and comfortable while your skin gets used to the retinol. A product for this skin needs oil-controlling ingredients to work best.

Cutis, 2006

How often should I use this cream?

You can use this moisturizing treatment daily in your evening routine, as acne-prone skin benefits from its soothing hydration. Regular daily application helps improve moisture levels and skin comfort without causing irritation.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to cause major breakouts for acne-prone skin, as reviewers rarely report this issue and the formula contains soothing ingredients like glycerin and sodium hyaluronate. However, because it lacks sufficient oil-control ingredients, acne-prone skin needs a product that balances moisture with oil-absorbing minerals and gentle exfoliants.

Clinical, Cosmetic and Investigational Dermatology, 2017

Can I use this cream around the eyes or on my body?

This moisturizing treatment is generally safe to use on the body and around the eyes, though it is primarily formulated for facial application. Its gentle ingredients like glycerin and sodium hyaluronate provide good hydration and soothing benefits for delicate areas.

Surgical and Radiologic Anatomy, 2002Clinical, Cosmetic and Investigational Dermatology, 2017

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool, limonene, citronellol, and parfum). Behenyl alcohol and cetyl alcohol are fatty alcohols, which soften the skin.

What the research says

  • Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.

    Journal of Cosmetic Dermatology, 2023

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

    The Journal of Dermatology, 2008

  • Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

    International Journal of Molecular Sciences, 2026

  • Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

    International Journal of Molecular Sciences, 2021

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

    Experimental Dermatology, 2003

  • Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

    Journal of Periodontology, 2009

  • Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

    Journal of Cosmetic Dermatology, 2022

Why other moisturizers fit acne-prone skin better

  • A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

    Journal of Cosmetic Dermatology, 2024

  • Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

    Molecules, 2023

Ingredients

Water, Bifida Lysate Ferment, Glycerin, Dicaprylyl Ether, Pentylene Glycol, Polyglyceryl-6 Distearate, Propanediol, Cetyl Esters, Jojoba Esters, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Octyldodecanol, Acacia Decurrens Flower Cera, Acacia Decurrens Wax Flower, Helianthus Annuus Seed Cera, Sunflower Wax Seed, Helianthus Annuus Seed Oil, Sunflower Seed Oil, Polymnia Sonchifolia Root Juice, Ceramide Np, Alpha-Glucan Oligosaccharide, Sodium Hyaluronate, Sodium Hydroxide, Sodium Stearoyl Glutamate, Salicyloyl Phytosphingosine, 2-Oleamido-1, 3-Octadecanediol, Adenosine, Mannose, Coco-Caprylate Caprate, Ascorbyl Glucoside, Hydroxyacetophenone, Hydroxypalmitoyl Sphinganine, Hydroxypropyl Phosphate Starch, Capryloyl Salicylic Acid, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Lactobacillus, Acetic Acid, Maltodextrin, Yeast Extract, Extrait De Levure, Polyglycerin-3, Polyglyceryl-3 Beeswax, Cetyl Alcohol, Tocopherol, Sodium Benzoate, Linalool, Limonene, Citronellol, Parfum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

Scan your face, then any product.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play