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Vitamin C and palmitoyl pentapeptide-4

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Vitamin C and palmitoyl pentapeptide-4: depends on the strength

Depends on the strength

Use them at different times of day, with vitamin C in the morning and the peptide in the evening, because they cancel each other out. Vitamin C brightens and protects the skin, while the peptide smooths fine lines and firms the skin. You can switch to using them on alternate days or wait ten minutes between steps if you want to use both.

Microneedle-Mediated Delivery of Copper Peptide Through Skin

Vitamin C products

Palmitoyl pentapeptide-4 products

Questions and answers

Can you use vitamin C and palmitoyl pentapeptide-4 together?

You should generally avoid using vitamin C and palmitoyl pentapeptide-4 together in the same routine, as they can reduce each other's effectiveness. Instead, use them in separate routines to help maintain their potency.

Which goes first, vitamin C or palmitoyl pentapeptide-4?

You should use vitamin C and palmitoyl pentapeptide-4 in separate routines because combining copper and peptides with vitamin C may reduce their effectiveness.

Are vitamin C and palmitoyl pentapeptide-4 good for sensitive skin?

Yes, they can be good for sensitive skin depending on the strength and type used. Vitamin C and certain peptides may help improve photoaged skin.

Experimental Dermatology, 2003International Journal of Cosmetic Science, 2005

Research on vitamin C and palmitoyl pentapeptide-4

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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