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Glycolic acid and palmitoyl pentapeptide-4

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Glycolic acid and palmitoyl pentapeptide-4: keep them apart

Keep them apart

Use them at different times of day with the acid in the morning and the peptide at night, because the acid breaks down the peptide. Mixing them makes the anti-aging peptide useless because the acid is too strong for it. You can fix this by using them in separate routines or waiting longer between steps.

Glycolic acid products

Palmitoyl pentapeptide-4 products

Questions and answers

Can you use glycolic acid and palmitoyl pentapeptide-4 together?

Keep glycolic acid and palmitoyl pentapeptide-4 apart by using them in separate routines, such as alternating morning and evening, because the low pH of glycolic acid may destabilize the peptide bonds and reduce their activity.

Which goes first, glycolic acid or palmitoyl pentapeptide-4?

Keep glycolic acid and palmitoyl pentapeptide-4 apart in your routine by using them in separate steps or at different times of day. Combining them directly is not recommended because the low pH of glycolic acid destabilizes the peptide bonds and reduces their bioactivity.

Are glycolic acid and palmitoyl pentapeptide-4 good for sensitive skin?

Keep glycolic acid and palmitoyl pentapeptide-4 apart because the low pH of glycolic acid destabilizes the peptide bonds and reduces its bioactivity.

Research on glycolic acid and palmitoyl pentapeptide-4

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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