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Niacinamide and tretinoin

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Niacinamide and tretinoin: depends on the strength

Depends on the strength

Use them at different times of day, applying niacinamide in the morning and tretinoin at night, to keep your skin calm. Using both at once can cause extra redness and dryness because they work hard on your skin at the same time. You can try a lower strength of tretinoin or wait a little longer between applying them.

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Niacinamide products

Tretinoin products

Questions and answers

Can you use niacinamide and tretinoin together?

Using niacinamide and tretinoin together depends on the strength, so you should use niacinamide in the morning and your retinoid at night. Musely The Spot Cream contains both ingredients.

Which goes first, niacinamide or tretinoin?

Using niacinamide and tretinoin depends on the strength, so you should use niacinamide in the morning and strong retinoids at night, or use Musely The Spot Cream. Separating them helps avoid the increased irritation that may happen when both activate cell turnover at the same time.

Are niacinamide and tretinoin good for sensitive skin?

Using niacinamide and tretinoin together depends on the strength, and they may cause irritation if not separated into morning and evening routines. Musely The Spot Cream contains both ingredients.

Research on niacinamide and tretinoin

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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