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Hexapeptide and protease

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

Hexapeptide and protease: keep them apart

Keep them apart

Use them at different times of day, applying the peptide product in the morning and the protease at night, because they cancel each other out. Protease breaks down the firming peptides so you miss out on anti-aging results. Separate your usage or use them on alternate nights to get the full benefit.

Hexapeptide products

Protease products

Questions and answers

Can you use hexapeptide and protease together?

No, you should keep hexapeptide and protease apart in your routine. Proteolytic enzymes may degrade peptide bonds and render the active ingredients inactive.

Which goes first, hexapeptide or protease?

Keep hexapeptide and protease apart in your routine because proteases degrade peptide bonds and render the hexapeptide inactive.

Are hexapeptide and protease good for sensitive skin?

Keep hexapeptide and protease apart in your routine because proteolytic enzymes can degrade peptide bonds and render the active peptides inactive. There are no specific restrictions for sensitive skin types, but combining these two ingredients in the same routine should be avoided.

Research on hexapeptide and protease

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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