L'Oreal Paris vs Bayer

Questions and answers

Research behind their key ingredients

• Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin

  Retinol · The Journal of Investigative Dermatology, 2000

• The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  Niacinamide · The British Journal of Dermatology, 2002

• Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

  Niacinamide · Antioxidants, 2021

• Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

  Hyaluronic acid · Dermatologic Therapy, 2022

• Topical use of dexpanthenol in skin disorders

  Panthenol · American Journal of Clinical Dermatology, 2002

• Improvement of naturally aged skin with vitamin A (retinol)

  Pro-retinol a, Retinol · Archives of Dermatology, 2007

• Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial

  Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020

• A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation

  Ferulic acid · Journal of the American Academy of Dermatology, 2008

• Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin

  Ferulic acid · Journal of Cosmetic Dermatology, 2008

• Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo

  Pro-retinol a, Retinol · International Journal of Cosmetic Science, 2017

• Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing

  Pro-retinol a, Retinol · The British Journal of Dermatology, 2019

• Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract

  Centella asiatica, Centella asiatica extract · Indian Journal of Pharmaceutical Sciences, 2016

• Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation

  Ascorbic acid, Ferulic acid · Journal of Cosmetic Dermatology, 2020

• Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study

  Retinyl palmitate · International Journal of Nanomedicine, 2021

• Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

  Azelaic acid · Pharmaceutics, 2021

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy

  Niacinamide · Journal of Cosmetic Dermatology, 2021

• Encapsulation and controlled release of retinol from silicone particles for topical delivery

  Pro-retinol a · Journal of Controlled Release, 2018

• A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

  Panthenol · The Journal of Dermatological Treatment, 2017

• A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population

  Salicylic acid · BioMed Research International, 2020

• Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

  Niacinamide · Scientific Reports, 2024

• Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration

  Adenosine · International Journal of Cosmetic Science, 2018

• Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system

  Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011

• The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study

  Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019

• Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy

  Centella asiatica extract · Molecules, 2023

• Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study

  Salicylic acid · Journal of Cosmetic Dermatology, 2024

• A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide

  Salicylic acid · Journal of Drugs in Dermatology, 2023

• Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs

  Vitamin e · Journal of Cosmetic Dermatology, 2022

• Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris

  Azelaic acid · Dermatology and Therapy, 2024

• Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris

  Capryloyl salicylic acid, Citric acid · Journal of Cosmetic Dermatology, 2021

• The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study

  Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023

• Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement

  Adenosine · Journal of Cosmetic Dermatology, 2019

• A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants

  Dimethicone · Ostomy/wound Management, 2005

• Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles

  Phenylethyl resorcinol · Journal of Cosmetic Dermatology, 2021

• Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study

  Panthenol · Journal of Cosmetic Dermatology, 2025

• Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin

  Vitamin e · Journal of Cosmetic Dermatology, 2024

• The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites

  Retinyl palmitate · Journal of Cosmetic Dermatology, 2013

• Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid

  Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998

• Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris

  Capryloyl salicylic acid · Journal of Drugs in Dermatology, 2013

• Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence

  Adenosine · International Journal of Molecular Sciences, 2026

• The Application of a Formulation Containing Hydroxypropyl Tetrahydropyrantriol and Niacinamide to Augment Anti-aging Benefits in a Double-blind, Randomized Nonablative Laser Treatment Study

  Hydroxypropyl tetrahydropyrantriol · The Journal of Clinical and Aesthetic Dermatology, 2025

• The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial

  Moroccan lava clay · Journal of Cosmetic Dermatology, 2025

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.