Hada Labo vs REN Clean Skincare

Questions and answers

Research behind their key ingredients

• The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  Niacinamide · The British Journal of Dermatology, 2002

• Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

  Sodium hyaluronate · Dermatologic Therapy, 2022

• Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin

  Ceramide · Scientific Reports, 2022

• Preparation and characterization of a lecithin nanoemulsion as a topical delivery system

  Hydroxylated lecithin · Nanoscale Research Letters, 2009

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy

  Niacinamide · Journal of Cosmetic Dermatology, 2021

• Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

  Niacinamide · Scientific Reports, 2024

• Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris

  Triethyl citrate · The British Journal of Dermatology, 2007

• Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs

  Vitamin e · Journal of Cosmetic Dermatology, 2022

• Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies

  Alpha-arbutin · Heliyon, 2023

• Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial

  Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022

• Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function

  Propanediol · International Journal of Cosmetic Science, 2024

• Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin

  Magnesium ascorbyl phosphate · Photochemistry and Photobiology, 2012

• Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model

  Jojoba seed oil · Frontiers in Pharmacology, 2024

• Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison

  Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2019

• Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract

  Salix nigra bark extract willow bark extract · Planta Medica, 2019

• An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging

  Salix nigra bark extract willow bark extract · Journal of Cosmetic Dermatology, 2010

• The anti-wrinkles properties of sodium acetylated hyaluronate

  Sodium acetylhyaluronate · Journal of Cosmetic Dermatology, 2022

• Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study

  Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026

• Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum

  Diglycerin · Journal of Oleo Science, 2016

• Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin

  Vitamin e · Journal of Cosmetic Dermatology, 2024

• Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides

  Glucosyl ceramide · International Journal of Molecular Sciences, 2022

• Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery

  Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022

• Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients

  3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026

• Combined Effect of Silybin and Sodium Acetylated Hyaluronate on UV-Induced Photoaging

  Sodium acetylhyaluronate · Skin Research and Technology, 2026

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.