Olay Regenerist Collagen Peptide 24 Serum for mature skin
Collagen Peptides
Niacinamide
Glycerin
Panthenol Vitamin B5
Tremella Fuciformis Sporocarp ExtractHigh
- HighNormal Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your normal skin as niacinamide and glycerin provide humectant action and barrier repair, while Palmitoyl Pentapeptide-4 and Tremella Fuciformis Sporocarp Extract offer significant plumping and firming benefits for wrinkles and fine lines.
- The serum's formulation supports collagen production and skin barrier function, addressing your concerns about wrinkles and fine lines effectively.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like niacinamide and panthenol.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.4Overall rating based on 1.5k+ reviewsBased on a very large amount of data, this serum is widely praised for its lightweight, non-greasy texture and its ability to provide deep, lasting hydration. Users frequently report that it effectively plumps the skin, smooths fine lines, and improves overall radiance, making it a popular choice for those targeting signs of aging, dullness, and dehydration.
Highlights
Deeply hydrating Mostly Mentioned
- “Skin feels significantly more hydrated”
- “Helps with dry skin”
- “Lasting hydration all day”
Fast absorbing Mostly Mentioned
- “Absorbs quickly into skin”
- “Sinks in fast”
- “No sticky residue”
Lightweight feel Often Mentioned
- “Very lightweight formula”
- “Not heavy or greasy”
- “Feels like nothing on”
Plumps skin Often Mentioned
- “Skin feels more plump”
- “Noticeably bouncier skin”
- “Looks more supple”
Smooths texture Often Mentioned
- “Skin feels very smooth”
- “Improved skin texture”
- “Soft finish on skin”
Fiddly dropper Sometimes Noted
- “Difficult to dispense product”
- “Dropper is hard to handle”
- “Inconvenient applicator design”
Limited tightening Rarely Noted
- “Did not notice tightening”
- “No visible contour change”
- “Expected more firming”
Price point Rarely Noted
- “A bit expensive”
- “Price is high for amount”
- “Wish it were cheaper”
Sources: lovi.care, olay.com, walmart.com, tryandreview.com, mamamia.com.au, agileskincare.com, and more
Questions and answers
What makes Olay Collagen Peptide 24 Serum a great fit for mature skin?
This serum is a great fit for mature skin because ingredients like niacinamide and glycerin help keep skin hydrated and repair its barrier, while peptides and mushroom extract help smooth out wrinkles and fine lines. It is also very safe and gentle, using soothing ingredients to prevent irritation while supporting firmer skin.
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin because it contains niacinamide and glycerin to hold in moisture, alongside collagen peptides and mushroom extract that help smooth out wrinkles and fine lines. It also includes panthenol to keep the skin calm and comfortable.
What do Collagen Peptides do for mature skin?
Collagen peptides help improve skin elasticity, hydration, and the appearance of wrinkles in mature skin with daily use over several weeks. Clinical studies show that this ingredient supports skin firmness by helping boost moisture and structural proteins.
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Where does this serum go in a skincare routine for mature skin?
This serum goes in the evening routine after cleansing and before moisturizing, following the simple steps for applying treatments. It is very unlikely to cause irritation and supports collagen production to help smooth fine lines.
Can I use this serum with retinol, and in what order?
Yes, you can use this serum with retinol by applying the serum first to help keep your skin comfortable and smooth. This product supports your skin barrier and is unlikely to cause irritation when paired with retinol.
Journal of Cosmetic Dermatology, 2024International Journal of Cosmetic Science, 2005
How often should I use this serum?
Apply this serum in your evening routine for simplicity and extra safety around sun exposure. It helps smooth fine lines and plump mature skin with a very low likelihood of irritation.
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin. It features a gentle formulation with soothing ingredients that keep the skin calm and comfortable.
American Journal of Clinical Dermatology, 2002Journal of Cosmetic Dermatology, 2025
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects.
International Journal of Cosmetic Science, 2005Combined therapy using a topical hyaluronic acid-niacinamide-Matrixyl serum and a multimodal facial device decreased TruSkin age by five years and reduced wrinkles more effectively than the serum alone in a 41-year-old woman with moderate facial aging over 12 weeks.
Cureus, 2026A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.
Journal of Cosmetic Dermatology, 2025A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic.
Journal of Cosmetic Dermatology, 2021Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls.
Frontiers in Medicine, 2024Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls.
Journal of Agricultural and Food Chemistry, 2020Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.
Journal of Cosmetic Dermatology, 2019Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.
Arzneimittel-Forschung, 2000Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two.
Auris, Nasus, Larynx, 2020Snow mushroom alcohol-based hand rub gel significantly improved skin moisture better than the placebo through 180 minutes while maintaining comparable antiseptic efficacy in 20 human volunteers.
Journal of Cosmetic Dermatology, 2021Tremella fuciformis extract demonstrates potential cutaneous benefits including skin antiaging, photoprotection, wound healing, and barrier protection based on in vitro and animal models.
Archives of Dermatological Research, 2023Tremella fuciformis inhibits melanogenesis by decreasing melanin content and tyrosinase expression in B16F10 cells while promoting wound healing in human HaCaT keratinocytes and Detroit 551 fibroblasts.
In Vivo, 2022
Ingredients
Water, Dimethicone, Niacinamide, Glycerin, Panthenol, Palmitoyl Pentapeptide-4, Tremella Fuciformis Sporocarp Extract, Hydroxyacetophenone, C13-14 Isoparaffin, Laureth-4, Polysorbate 20, Laureth-7, Disodium Edta, Polyacrylamide, Dimethicone Crosspolymer, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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