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Neora Advanced SIG-1273 Concentrated Serum for sensitive skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Neora Advanced SIG-1273 Concentrated Serum

Average

  • HighNormal Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for sensitive skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate hydration for your normal skin, as glycerin and sodium hyaluronate provide humectant benefits that are generally suitable for your skin type. These ingredients offer general skincare benefits, but are mostly supportive for your specific concerns of redness and irritation.
  • The formula is highly suitable for normal skin due to the presence of sodium hyaluronate and glycerin with humectant action.
  • The safety profile is excellent, with no risks of irritation for your normal skin with sensitivity due to the absence of prohibited or harsh ingredients.

How to apply

  • Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
  • Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
  • Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
  • Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
  • Always do a patch test before your first use and avoid getting the serum too close to your eyes .

People Say

★3.5Overall rating based on 100+ reviews

Based on limited data, users describe the serum as a lightweight, hydrating formula that leaves skin feeling smooth and looking radiant. While many report improvements in skin texture and a healthy glow, some users feel the anti-aging results are subtle rather than dramatic, especially when weighed against the product's premium price point.

Highlights

  • High price Mostly Mentioned
    • “Extremely high prices”
    • “Expensive”
    • “Not worth the cost”
  • Hydrating effect Often Mentioned
    • “Extra burst of hydration”
    • “Feels hydrating”
    • “Leaves skin plump”
  • Lightweight texture Often Mentioned
    • “Feels very light”
    • “Lightweight and fits routine”
    • “Gel consistency”
  • Radiant glow Sometimes Noted
    • “Brighter and beautiful”
    • “Naturally radiant glow”
    • “Leaves a nice glow”
  • Smoother skin Sometimes Noted
    • “Skin looks smoother”
    • “Improved texture”
    • “Feels super smooth”
  • MLM model Sometimes Noted
    • “Business model frustration”
    • “Auto-ship requirements”
    • “Financial obligation”
  • Subtle results Sometimes Noted
    • “Didn't see dramatic changes”
    • “Not memorable”
    • “Didn't wow you”

Sources: lovi.care, neora.com, youtube.com, facebook.com, ebay.com, trendhunter.com, and more

Questions and answers

How well does Advanced SIG-1273 Concentrated Serum work for sensitive skin?

This serum works moderately well for sensitive skin, offering basic hydration that is generally safe but mostly supportive rather than targeting redness and irritation directly. A treatment for this skin needs potent antioxidants, skin-repairing ingredients like niacinamide or snail secretion filtrate, and calming components that actively soothe redness and irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this serum a good fit for sensitive skin?

Sodium hyaluronate and glycerin make this serum a good fit for sensitive skin by offering gentle, moderate hydration. This product of this type needs effective ingredients that target redness and irritation, potent antioxidants, and skin-repairing components to provide a superior fit for sensitive skin.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.

Journal of Drugs in Dermatology, 2025Journal of Cosmetic Dermatology, 2018

What does Glycerin do for sensitive skin?

Glycerin helps keep sensitive skin soft and deeply hydrated while supporting the skin barrier. It is unlikely to cause irritation and may protect against dryness and roughness.

The British Journal of Dermatology, 2008Acta Dermato-venereologica, 1999

Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. While it provides moderate hydration, sensitive skin prone to redness and irritation needs additional soothing and calming ingredients to truly thrive.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first in your evening routine and following with a soothing moisturizer. This approach helps support comfort while keeping your skin calm and hydrated.

Journal of Cosmetic Dermatology, 2024

How often should I use this serum?

You can use this treatment in your evening routine, as this helps keep things simple and safe around sun exposure. A product of this type needs soothing ingredients like Centella asiatica stem cells extract and extra hydration to properly calm redness and irritation on sensitive skin.

Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin because it lacks heavy, pore-blocking ingredients and has a very safe formula. It helps keep skin comfortable without triggering irritation, though a product for this skin needs extra soothing and calming ingredients to truly target redness.

Clinical, Cosmetic and Investigational Dermatology, 2017

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

  • Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels.

    International Journal of Molecular Sciences, 2018

  • A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris.

    Journal of Drugs in Dermatology, 2013

  • Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris.

    Journal of Cosmetic Dermatology, 2021

  • Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone.

    Dermatologic Surgery, 1997

Why other serums fit sensitive skin better

Ingredients

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

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