Neora Advanced SIG-1273 Concentrated Serum for dry sensitive skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels.

  International Journal of Molecular Sciences, 2018

• A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris.

  Journal of Drugs in Dermatology, 2013

• Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris.

  Journal of Cosmetic Dermatology, 2021

• Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone.

  Dermatologic Surgery, 1997

Why other serums fit dry sensitive skin better

• Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks.

  Journal of Cosmetic Dermatology, 2022

• In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle.

  Skin Pharmacology and Physiology, 2026

• Hydrogels containing vitamin E-loaded nanostructured lipid carriers exhibited better occlusive properties and long-lasting effects, while vitamin E-loaded nanoemulsions performed a faster skin hydration effect and were selected as more attractive for skin application.

  Colloids and Surfaces. B, Biointerfaces, 2019

Ingredients

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.