MEDI THERAPY Retinal Skin Booster for mature skin
Retinal
Centella Asiatica
NiacinamideAverage
- SuperiorNormal Skin Fit
- AverageEffectiveness
- ExcellentSafety
Works for mature skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate treatment for minimizing fine lines and wrinkles, as retinal promotes skin regeneration and Centella Asiatica provides soothing benefits for your normal skin.
- Niacinamide further supports skin health by offering anti-inflammatory action, contributing to overall skin comfort.
- The product is safe for your normal skin due to the absence of harsh ingredients and the inclusion of soothing components.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.7Overall rating based on 1.3k+ reviewsBased on a very large amount of data, users with sensitive, acne-prone, and aging skin report this product is gentle and effective, improving skin texture and hydration without irritation. Many users notice a radiant glow, reduced pore visibility, and smoother skin. Some users with very dry skin mention needing additional moisturization.
Highlights
Gentle & non-irritating Mostly Mentioned
- “Gentle enough for daily use”
- “No burning or redness”
- “Great for sensitive skin”
- “Zero irritation even on first use”
Hydrating & lightweight Often Mentioned
- “Hydration without dryness”
- “Absorbs beautifully”
- “Not greasy or heavy”
- “Skin feels plump”
Improves texture & pores Often Mentioned
- “Skin feels baby soft”
- “Pores look noticeably smaller”
- “Texture became incredibly smooth”
- “Refined and put-together”
Fades acne & marks Sometimes Noted
- “Fades acne scars”
- “Reduces breakouts”
- “Helps with discoloration”
- “Calms troubled skin”
Great value Sometimes Noted
- “Generous amount for price”
- “Lasts over two months”
- “Absolute steal”
- “Can use on body too”
Dry skin needs more Rarely Noted
- “Need to layer moisturizer”
- “Not enough for winter”
- “Hydration doesn't last long”
- “Dry skin needs more”
Mild stinging Rarely Noted
- “Stings on open wounds”
- “Burned slightly around eyes”
- “Tingle on application”
- “Sensitive areas reacted”
No visible change Rarely Noted
- “No visible change”
- “Didn't see brightening”
- “Don't notice anything different”
- “Just okay”
Packaging quality Rarely Noted
- “Label riddled with bubbles”
- “Messy label application”
- “Hard to see product level”
- “Pump dispenses too much”
Sticky finish Rarely Noted
- “A little sticky”
- “Feels tacky after application”
- “Hair sticks to face”
- “Sticky residue”
Sources: lovi.care, gogumacider.com, oliveyoung.com, gopicky.com, skinsort.com, amazon.com, and more
Questions and answers
How well does MEDI THERAPY Retinal work for mature skin?
MEDI THERAPY Retinal Skin Booster works moderately well for mature skin by helping to smooth fine lines and calm the skin. To work best for this skin, a treatment needs high concentrations of potent antioxidants, deep hydrating components, and skin-repairing ingredients.
Indian Journal of Pharmaceutical Sciences, 2016Molecules, 2023
Which ingredients make this serum a good fit for mature skin?
Retinal, Centella Asiatica, and Niacinamide make this serum a good fit for mature skin by helping smooth fine lines, calming the skin, and supporting overall skin health. To fit this skin type even better, products of this type need high-quality anti-aging ingredients, strong antioxidants, and deeply hydrating components.
Indian Journal of Pharmaceutical Sciences, 2016Molecules, 2023
What does Retinal do for mature skin?
Retinal helps smooth fine lines, improve uneven skin tone, refine texture, and tighten pores on mature skin. It may also boost skin thickness and elasticity over time while keeping irritation low compared to stronger options.
Journal of Drugs in Dermatology, 2024Journal of Cosmetic Dermatology, 2018
What does Centella Asiatica do for mature skin?
Centella asiatica helps mature skin by boosting moisture, keeping it smooth, and supporting collagen to make skin look firmer and less wrinkled. It also helps calm redness and protect skin from daily stress and aging.
International Journal of Molecular Sciences, 2025Scientific Reports, 2021
Where does this serum go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing toner and before moisturizer, as active serums fit best at night for simplicity and safety around sun exposure. Mature skin of this type needs products containing retinal, Centella Asiatica, and niacinamide to help soften fine lines and soothe the skin.
Can I use it with vitamin C, and in what order?
You can use this treatment with vitamin C by applying vitamin C in your morning routine and this treatment at night, as using them separately helps keep your skin calm and comfortable. To better suit mature skin, this type of product also needs ingredients that deeply boost firmness and smooth fine lines.
How often should I use this serum?
This treatment works well in the evening routine, and a product of this type for mature skin needs smoothing ingredients like retinoids along with calming components like Centella Asiatica to soften fine lines safely.
Facial Plastic Surgery, 2014Indian Journal of Pharmaceutical Sciences, 2016
Can it clog pores, cause breakouts or purging for mature skin?
MEDI THERAPY Retinal Skin Booster is unlikely to clog pores or cause breakouts on mature skin, though the retinal may cause mild initial purging as skin cell turnover speeds up. A product for this skin needs gentle exfoliating ingredients and soothing plant extracts like Centella Asiatica to keep pores clear while maintaining comfort.
Indian Journal of Pharmaceutical Sciences, 2016Molecules, 2023
What the research says
Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.
Indian Journal of Pharmaceutical Sciences, 2016Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.
The British Journal of Dermatology, 2002Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index.
Journal of Cosmetic Dermatology, 2018Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance.
Dermatology, 2002Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients.
Dermatology, 1999Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.
Journal of Alternative and Complementary Medicine, 2020A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.
Journal of Cosmetic Dermatology, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005
Ingredients
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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