Lancôme Advanced Génifique Night Cream for mature skin
Bifida Lysate Ferment
Adenosine
Sodium Hyaluronate
Ceramide Np
Ascorbyl Glucoside
High
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for mature skin; a few moisturizers fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your normal skin due to the presence of Bifida Lysate Ferment and Sodium Hyaluronate, which offer barrier repair and humectant action, respectively.
- It offers moderate benefits for wrinkles and fine lines due to the presence of Adenosine and Ascorbyl Glucoside in concentrations that promote collagen production and antioxidant protection.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.7Overall rating based on 2.7k+ reviewsBased on a very large amount of data, this product is highly regarded for its ability to deeply hydrate dry and aging skin, effectively repair the moisture barrier, and leave the complexion feeling plump, smooth, and radiant by morning. It is frequently noted for reducing the appearance of fine lines and smoothing the skin texture. While most users find it absorbs quickly without a greasy feel, a small number of individuals with sensitive skin have reported experiencing breakouts or irritation, and some dislike the fragrance.
Highlights
Deeply hydrating Mostly Mentioned
- “The product provides deep hydration and visible rejuvenation.”
- “Skin feels softer, smoother, and more hydrated.”
- “Leaves skin moisturized and glowing.”
- “Thick and moisturizing.”
Absorbs quickly Often Mentioned
- “Doesn't have an oil feeling it's very light.”
- “Absorbs quickly and leaves skin feeling refreshed without feeling greasy.”
- “Thicker cream that does not make face feel greasy.”
- “Does not leave the skin feeling sticky.”
Softens and smooths Often Mentioned
- “Face is so soft, smooth and not puffy.”
- “Goes on smoothly and makes skin feel like butter.”
- “Skin feels softer, smoother, and more hydrated.”
- “Leaves the skin feeling softer, smoother, and more radiant.”
Reduces fine lines Sometimes Noted
- “Helps with wrinkles and makes skin soft.”
- “Noticed a difference with the crows feet around my eyes.”
- “Helps reduce the appearance of fine lines and wrinkles.”
- “Reduces the appearance of fine lines and wrinkles, to leave skin looking youthful.”
Causes breakouts Rarely Noted
- “Caused swelling and breakouts.”
- “Had a few pimples that I didn't have before.”
- “Did have one pimple below my eye.”
- “Tiny pimples (bumps) on my jaw line and above my brows.”
Skin irritation Rarely Noted
- “Started burning my face.”
- “Smells very bad and itchy.”
- “Caused swelling and breakouts.”
- “Afraid to use it because it made me wonder what is in it.”
Unpleasant smell Rarely Noted
- “Smells terrible, similar to hair bleach.”
- “Smells like old sunscreen.”
- “Smells very bad.”
- “Disliked the fragrance.”
Sources: lovi.care, macys.com, lookfantastic.com, ulta.com, lancome-usa.com, nordstromrack.com, and more
Questions and answers
What makes Lancôme Advanced Génifique Night Cream a great fit for mature skin?
Lancôme Advanced Génifique Night Cream is a great fit for mature skin because it contains Bifida Lysate Ferment and Sodium Hyaluronate to repair the skin barrier and draw in moisture. It also helps smooth fine lines and protects against damage with adenosine and vitamin c, all with an excellent safety profile that is unlikely to cause irritation.
Which ingredients make this cream a good fit for mature skin?
This cream is a great fit for mature skin due to Bifida Lysate Ferment and Sodium Hyaluronate, which help repair the skin barrier and keep it plump. It also contains Adenosine and Ascorbyl Glucoside, which may help soften fine lines and support firmness.
What does Bifida Ferment Lysate do for mature skin?
Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, which keeps mature skin feeling soft and comfortable. It also provides antioxidant support that may protect against everyday stress, though products for mature skin also need firming and smoothing ingredients like peptides and retinol.
Journal of Cosmetic Dermatology, 2023Experimental Dermatology, 2010
What does Adenosine do for mature skin?
Adenosine helps smooth out wrinkles and keeps mature skin looking firm and well-hydrated. It supports collagen production to improve overall elasticity and reduce the look of lines.
International Journal of Cosmetic Science, 2018Journal of Cosmetic Dermatology, 2019
Where does this cream go in a skincare routine for mature skin?
This moisturizing treatment goes in the evening routine after cleansing and before your final moisturizer, or it can be used during your morning routine before sunscreen. It is a great fit for mature skin because it helps repair the skin barrier and provides moderate benefits for fine lines with a very low risk of irritation.
The Journal of Dermatological Treatment, 2022International Journal of Molecular Sciences, 2026
Can I use this cream with retinol, and in what order?
You can use this cream with retinol by applying it as your moisturizer step after your retinol treatment. Using a moisturizer like this helps keep your skin soft and comfortable while reducing the irritation that retinol may sometimes cause.
How often should I use this cream?
You can use this moisturizing treatment daily as part of your evening routine to help keep your mature skin soft, smooth, and well-hydrated. Applying it regularly supports skin barrier function and helps reduce the look of fine lines over time.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for mature skin?
This cream is unlikely to clog pores or cause breakouts for mature skin, as it has an excellent safety profile with very low complaints of breakouts and no harsh ingredients.
Can I use this cream around the eyes or on my body?
You can use this moisturizing treatment around the eyes, though the skin there is much thinner than on the body. Its gentle ingredients make it unlikely to cause irritation, but it is primarily formulated for facial use.
Is this cream fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (linalool, limonene, citronellol, and parfum). Behenyl alcohol and cetyl alcohol are fatty alcohols, which soften the skin.
What the research says
Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.
Drug Delivery, 2017Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.
International Journal of Molecular Sciences, 2026Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.
International Journal of Cosmetic Science, 2018Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.
The Journal of Dermatology, 2008Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.
International Journal of Molecular Sciences, 2021Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures.
The Journal of Investigative Dermatology, 2007Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Bifida Lysate Ferment, Glycerin, Dicaprylyl Ether, Pentylene Glycol, Polyglyceryl-6 Distearate, Propanediol, Cetyl Esters, Jojoba Esters, Ammonium Polyacryloyldimethyl Taurate, Behenyl Alcohol, Octyldodecanol, Acacia Decurrens Flower Cera, Acacia Decurrens Wax Flower, Helianthus Annuus Seed Cera, Sunflower Wax Seed, Helianthus Annuus Seed Oil, Sunflower Seed Oil, Polymnia Sonchifolia Root Juice, Ceramide Np, Alpha-Glucan Oligosaccharide, Sodium Hyaluronate, Sodium Hydroxide, Sodium Stearoyl Glutamate, Salicyloyl Phytosphingosine, 2-Oleamido-1, 3-Octadecanediol, Adenosine, Mannose, Coco-Caprylate Caprate, Ascorbyl Glucoside, Hydroxyacetophenone, Hydroxypalmitoyl Sphinganine, Hydroxypropyl Phosphate Starch, Capryloyl Salicylic Acid, Trisodium Ethylenediamine Disuccinate, Lactic Acid, Lactobacillus, Acetic Acid, Maltodextrin, Yeast Extract, Extrait De Levure, Polyglycerin-3, Polyglyceryl-3 Beeswax, Cetyl Alcohol, Tocopherol, Sodium Benzoate, Linalool, Limonene, Citronellol, Parfum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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