CeraVe SA Cream for mature skin

How to apply

Questions and answers

What the research says

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

  Scientific Reports, 2024

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A facial cream containing Centella asiatica leaf extract, ceramide NP, and panthenol reduced mean SS-10 scores by 66% and 76% after 2 and 4 weeks in Chinese females with sensitive skin, providing effective soothing and barrier-repairing properties with mild adverse events.

  Journal of Cosmetic Dermatology, 2025

• Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients.

  CMAJ, 2010

• A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase.

  BioMed Research International, 2020

• Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy.

  Journal of Cosmetic Dermatology, 2024

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical and ingested vitamin D3 significantly reduced chloasma severity scores and improved wound healing outcomes, skin hydration, and skin barrier function in 480 individuals compared to a placebo.

  International Wound Journal, 2024

• Topical vitamin D administration in acne vulgaris lesions significantly reduced IL-1β levels and decreased inflammatory lesion severity compared to placebo.

  Clinical, Cosmetic and Investigational Dermatology, 2024

• Topical calcitriol decreased UV-induced DNA damage and sunburn cell density in healthy volunteers while reducing Mantoux responses at high doses, demonstrating both protective and immunosuppressive effects.

  Experimental Dermatology, 2010

Ingredients

Water, Glycerin, Behentrimonium Methosulfate, Cetearyl Alcohol, Mineral Oil, Glyceryl Stearate Se, Ammonium Lactate, Salicylic Acid, Triethanolamine, Cetyl Alcohol, Niacinamide, Peg-100 Stearate, Cholecaciferol Oil Vitamin D In Corn Oil, Ceramide Np, Ceramide 6-11, Ceramide 1, Cholesterol, Phytosphingosine, Sodium Hyaluronate, Phenoxyethanol, Dimethicone, Methylparaben, Edetate Disodium, Propylparaben, Sodium Lauroyl Lactylate, Carbomer, Xanthan Gum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.