Vanicream Sunscreen Broad Spectrum SPF 50+ for acne-prone skin

How to apply

Questions and answers

What the research says

• Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles selectively inhibited C. acnes, outperformed erythromycin in preclinical acne models, and safely reduced acne lesions and redness in a clinical trial.

  Journal of Controlled Release, 2025

• Topical 0.5% hyaluronic-ZnO nanogel applied twice daily reduced inflammatory-lesion counts by 58% at week four in human subjects compared to baseline without causing erythema.

  Biomedicines, 2025

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate.

  Scientific Reports, 2020

• A preservative system containing 1,2-hexanediol and caprylyl glycol showed no delayed Type IV dermal sensitivity reactions in 200 subjects when tested as a 15% mixture in carbomer gel and in a cosmetic formulation.

  Cutaneous and Ocular Toxicology, 2009

• Nels cream achieved a similar reduction in inflammatory and noninflammatory lesion counts compared to 5% benzoyl peroxide in acne vulgaris patients, but caused significantly fewer side-effects such as peeling and dryness.

  Clinical and Experimental Dermatology, 2000

• Topically applied coated and uncoated zinc oxide nanoparticles under flexing and massage are retained in the stratum corneum with no significant penetration into the viable epidermis and no cellular toxicity in human skin.

  Nanomedicine, 2016

• Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.

  Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

• A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

  Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

• An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.

  Aesthetic Plastic Surgery, 2018

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

Ingredients

Zinc Oxide, Allantoin, Butyloctyl Salicylate, C12-15 Alkyl Benzoate, Caprylyl Glycol, Dimethiconol Propylsilsesquioxane Silicate Crosspolymer, Glyceryl Behenate, Glyceryl Dibehenate, Glyceryl Stearate, Isodecyl Salicylate, Isopropyl Isostearate, Lecithin, Neopentyl Glycol Diheptanoate, 1,2-Hexanediol, Polyester-7, Polyglyceryl-3 Polyricinoleate, Propanediol, Silica Silylate, Sodium Chloride, Squalane, Tribehenin, Tridecyl Salicylate, Water

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.