# Timeless Matrixyl 3000 Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Timeless](https://lovi.care/skincare/uk/brands/timeless)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for oily skin as Glycerin and Sodium Hyaluronate provide hydration without exacerbating oiliness, though it lacks strong seboregulating ingredients for optimal oil control.
- The serum provides general hydration and soothing benefits due to Aloe Barbadensis, which is beneficial for your oily skin, but it does not contain targeted ingredients to effectively address your primary concerns of acne, blemishes, and breakouts.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Matrixyl 3000, Sodium Hyaluronate, Glycerin, Aloe Barbadensis, Dehydroacetic Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))
- Microbial cellulose patches containing 1,3-dihydroxy-2-propanone act as biocarriers that enable DHA transport into the stratum corneum and induce skin color changes, with intensity increasing with concentration and application time. ([Polymers, 2018](https://pubmed.ncbi.nlm.nih.gov/30966473/))
- Topical treatment with docosahexaenoic acid (DHA) upregulated barrier differentiation proteins and reduced inflammatory cytokine expression in human keratinocytes and inflammatory reconstructed human epidermis models. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31480216/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its ability to deeply hydrate, plump, and soften the skin, making it a favorite for mature and dry skin types targeting fine lines and loss of elasticity. The vast majority of users appreciate its lightweight, non-sticky texture and noticeable firming outcomes. A small subset of reviewers report a lack of visible anti-aging results or express disappointment with the price-to-value ratio.

- Liked: Hydrating, plumping (mostly mentioned)
- Liked: Lightweight, absorbs fast (mostly mentioned)
- Liked: Improves firmness (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Old product (rarely noted)
- Disliked: Poor value (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Timeless Matrixyl 3000 work for oily acne-prone skin?

Timeless Matrixyl 3000 Serum works moderately well for oily acne-prone skin, as glycerin and sodium hyaluronate provide hydration without adding oiliness, though it lacks targeted ingredients for breakouts. A treatment for this skin needs ingredients like niacinamide, propolis, or vitamin C to control excess oil and clear blemishes.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Glycerin, Sodium Hyaluronate, and Aloe Barbadensis make this serum an average fit by providing hydration and soothing benefits without making your skin oily or causing irritation. However, a treatment of this type needs targeted ingredients like niacinamide and propolis or vitamin c to properly control oil and help with acne and breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Matrixyl 3000 do for oily acne-prone skin?

Matrixyl 3000 helps smooth fine lines and supports collagen levels, but because it is typically formulated in rich moisturizers, it may feel too heavy for oily acne-prone skin. Oily acne-prone skin needs lightweight, oil-free hydrators with ingredients like niacinamide or hyaluronic acid that keep skin soft without clogging pores.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine, applied after cleansing and toning and before your moisturizer. It offers moderate suitability for oily skin by providing hydration without adding oiliness, but an oily acne-prone skin needs targeted ingredients to control oil and address breakouts.

### Can I use it with vitamin C, and in what order?

You can use this serum with vitamin C by applying the vitamin C first on clean skin and then following with this treatment. It is unlikely to irritate your skin, but because it lacks strong oil-controlling and breakout-fighting ingredients, oily acne-prone skin needs a product with targeted acne fighters and oil-balancing ingredients.

### How often should I use this serum?

This serum works in the evening routine for your oily acne-prone skin, as the ingredients hydrate without making you oily and have a very safe profile. However, this skin type needs targeted blemish-fighting and oil-controlling ingredients to properly handle acne and breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can it clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to cause breakouts or clog pores because it has an excellent safety profile without harsh ingredients, but it does not contain targeted ingredients to effectively address acne and blemishes. Oily acne-prone skin needs products with strong oil-controlling ingredients to manage breakouts.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — £25.95 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — £25.95 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/uk/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — £26.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — £30.37 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — £14.80 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Water, Matrixyl 3000, Aloe Barbadensis, Glycerin, Sodium Hyaluronate, Benzyl Alcohol, Dehydroacetic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/timeless/matrixyl-3000-serum/for/oily-acne-prone-skin