# The Ordinary Argireline Solution 10% for combination skin

**Lovi Fit: Low fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Concerning.

Page: https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [The Ordinary](https://lovi.care/skincare/uk/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for combination skin; the serums alongside fit it better.

## Why this fit

- Offers moderate plumping for your combination skin due to acetyl hexapeptide-8, which supports skin elasticity but does not directly address oily shine.
- The formula is safe for your combination skin as it lacks harsh or prohibited ingredients, though it could benefit from additional components for comprehensive oil control.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/combination-skin): Low (this page)
- [Sensitive skin](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/oily-acne-prone-skin): Average

## Key ingredients

Acetyl Hexapeptide-8, Propanediol, Gellan Gum, Phenoxyethanol, Sodium Chloride

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A mixture of propanediol, xylitol, and caprylic acid demonstrated in vitro antimicrobial activity against C. acnes and S. aureus, reduced 5-alpha reductase expression, and decreased skin oiliness, porphyrin, and inflammatory lesions in participants over 28 days. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- Sustainable cosmetic products formulated with renewable PDO-based emulsifiers showed equivalent performance in sensory and moisturization evaluations compared to those formulated with petroleum-derived PEG-based emulsifiers. ([Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/29465392/))
- Gellan gum hydrogel films co-encapsulating ofloxacin with tea tree or lavender oil achieved 98% wound contraction and completely healed epidermis in rats after ten days of treatment compared to baseline. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33130262/))
- Oleuropein-rich gellan gum and sodium alginate hydrogel films acted as effective antioxidant and photoprotectant treatments against UVA-induced photoaging in normal human dermal fibroblasts. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37298828/))
- Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels scavenged 88.5% of free radicals, reduced transepidermal water loss by up to 33.3%, and improved moisture content and skin structural characteristics in a murine dry skin model. ([International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41224059/))
- Calcium hydroxylapatite diluted with normal saline combined with microfocused ultrasound with visualization improved age-related changes in the lower face, neck, and décolleté and stimulated collagen and elastin fibers in 20 subjects. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32272518/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Topical application of magnetized saline water serum improved skin hydration, reduced transepidermal water loss, sebum content, melanin index, and erythema index, and activated autophagy by increasing Beclin-1 and decreasing mTOR in females wanting to enhance facial and neck skin appearance. ([Cureus, 2023](https://pubmed.ncbi.nlm.nih.gov/38130575/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, users frequently describe this serum as "Botox in a bottle," praising its ability to soften dynamic facial lines, particularly on the forehead and around the eyes. While many with mature or expressive skin report smoother texture and reduced wrinkle depth with consistent use, a notable portion of users saw no visible difference, suggesting efficacy varies significantly by skin type and depth of lines.

- Liked: Softens dynamic lines (mostly mentioned)
- Liked: Affordable price point (often mentioned)
- Liked: Lightweight watery texture (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Too runny/watery (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Results take time (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is The Ordinary Argireline Solution a weak match for combination skin?

This treatment is a weak match for your combination skin because it only offers moderate plumping and lacks direct control for oily shine. A product of this type needs effective ingredients like niacinamide, zinc PCA, and propolis to regulate oiliness, enhance radiance, and provide balanced hydration without irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### Which ingredients make this serum a poor fit for combination skin?

This serum is a weak match because acetyl hexapeptide-8 only offers moderate plumping and does not manage oily shine. A treatment for combination skin needs effective ingredients like niacinamide, zinc PCA, and propolis to balance oiliness and provide hydration without excess oil.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### What does Argireline do for combination skin?

Argireline helps smooth out lines and keeps combination skin feeling soft when applied twice daily. This ingredient may reduce wrinkle depth and improve overall skin texture, though its absorption through the skin is quite low.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Propanediol do for combination skin?

Propanediol helps keep combination skin hydrated and smooth while balancing areas that tend to get oily. It draws moisture into the skin without feeling heavy and may help reduce excess oil and shine throughout the day.
Sources: [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/), [Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34771112/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after your cleansing toner and before your moisturizer. It is unlikely to cause irritation since it lacks harsh ingredients, but a product for this skin type needs extra components to help control oily shine.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol. The formula is safe for your skin, but combination skin needs a product of this type to include additional components for comprehensive oil control.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. A product of this type for combination skin needs extra oil control components alongside acetyl hexapeptide-8 to properly balance oily shine while supporting skin elasticity.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin because its formula lacks heavy oils and harsh ingredients. To work best for this skin type, it needs extra ingredients to help balance oily shine.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — £24.20 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/uk/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — £248.00 at Amazon

## Routine for combination skin

### AM

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — £30.37 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — £14.80 at Amazon

### PM

- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/uk/p/pyunkang-yul/deep-cleansing-oil/for/combination-skin) — Superior fit — £23.92 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Cleansing Toner: [REN Clean Skincare Ready Steady Glow Daily AHA Tonic](https://lovi.care/skincare/uk/p/ren-clean-skincare/ready-steady-glow-daily-aha-tonic/for/combination-skin) — Superior fit — £30.99 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/uk/p/peach-and-lily/glass-skin-refining-serum/for/combination-skin) — Superior fit — £59.74 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — £14.80 at Amazon

### Weekly

- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/uk/p/pyunkang-yul/deep-cleansing-oil/for/combination-skin) — Superior fit — £23.92 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/uk/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — £19.00 at Amazon
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/uk/p/vt-cosmetics/cica-purifying-mask/for/combination-skin) — High fit — £19.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — £30.37 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/uk/p/peach-and-lily/glass-skin-refining-serum/for/combination-skin) — Superior fit — £59.74 at Amazon

## Where to buy

- Amazon.co.uk: £7.36 (https://www.amazon.co.uk/dp/B072JH13CD?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: £9.20 (https://www.lookfantastic.com/p/the-ordinary-10-argireline-solution-30ml/11416769/)
- Notino: £9.60 (https://www.notino.co.uk/the-ordinary/argireline-solution-10-wrinkle-and-fine-line-reducing-serum/p-16204758/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin, Ethoxydiglycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/argireline-solution-10/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/argireline-solution-10/for/combination-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/argireline-solution-10/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/argireline-solution-10/for/combination-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/argireline-solution-10/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/argireline-solution-10/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/argireline-solution-10/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/the-ordinary/argireline-solution-10/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/argireline-solution-10/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/argireline-solution-10/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/argireline-solution-10/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/argireline-solution-10/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/argireline-solution-10/for/combination-skin