# Skinbetter Science Alto Defense Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Skinbetter Science](https://lovi.care/skincare/uk/brands/skinbetter-science)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- This formulation offers moderate benefits for your redness and irritation, as ingredients like Glycyrrhiza Glabra Root Extract and Bisabolol help to soothe and calm the skin, while Hydrolyzed Sodium Hyaluronate and Glycerin provide excellent humectant action for your normal skin.
- It provides good protection against environmental stressors due to antioxidants like ergothioneine and tetrahexyldecyl ascorbate.
- The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Vitis Vinifera Seed Extract Grape Seed Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Curcuma Longa Root Extract, Superoxide Dismutase, Tetrahexyldecyl Ascorbate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- A 3-in-1 anti-aging topical night serum-in-oil applied once daily decreased wrinkles by 11%, increased skin firmness by 8%, reduced redness by 70%, and improved overall skin quality and complexion in 103 female subjects over 28 to 84 days compared to baseline. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/))
- Topical CE Ferulic plus resveratrol BE serum following ablative fractional CO2 laser treatment reduced erythema index (308.9 vs. 325.3), shortened complete scabbing detachment time (6.0 vs. 6.5 days), decreased melanin index (-7.4% vs. +0.2%), and improved skin hydration compared to normal saline in 51 Chinese patients. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38828801/))
- Resveratrol cream improved skin hydration and tightening compared to cream without resveratrol in a group of probands. ([Acta Biochimica Polonica, 2019](https://pubmed.ncbi.nlm.nih.gov/31518087/))
- Topical application of a water-in-oil emulsion containing 2% Muscat hamburg grape seed extract significantly improved melanin, elasticity, and sebum content compared to a placebo in human volunteers over 8 weeks, with no reported skin hypersensitivity. ([International Journal of Cosmetic Science, 2015](https://pubmed.ncbi.nlm.nih.gov/25402429/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of curcumin or turmeric treats various skin conditions by leveraging antioxidant, anti-inflammatory, and antimicrobial properties. ([Skin Pharmacology and Physiology, 2023](https://pubmed.ncbi.nlm.nih.gov/38008088/))
- Topical formulations of curcumin target oxidative damage and inflammation to improve wound healing in animal models. ([Drug Discovery Today, 2017](https://pubmed.ncbi.nlm.nih.gov/28711364/))
- A curcumin-loaded spanlastic anti-aging gel utilizing formula F5 incorporated into 2% HPMC E50 demonstrated sustained release action, compatibility, and the ability to penetrate skin layers to a depth of about 112.5 um without signs of irritation. ([Saudi Pharmaceutical Journal, 2024](https://pubmed.ncbi.nlm.nih.gov/38178851/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## What reviewers say

Most users report a more luminous and even complexion without irritation. A few users note the high price point, small packaging, and occasional lack of visible results.

- Liked: Improves skin texture (often mentioned)
- Liked: Reduces skin redness (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Gentle and non-irritating (sometimes noted)
- Liked: Hydrates the skin (sometimes noted)
- Disliked: No visible results (rarely noted)
- Disliked: Small bottle size (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Alto Defense Serum work for sensitive skin?

Skinbetter Science Alto Defense Serum is an average fit for sensitive skin, offering moderate benefits for redness and irritation with no irritation risks. To fit this skin better, a treatment of this type needs soothing and calming ingredients like niacinamide or snail secretion filtrate alongside potent antioxidants and hydrating components.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum works for sensitive skin because licorice root extract and bisabolol help soothe and calm redness and irritation, while hydrolyzed sodium hyaluronate and glycerin keep the skin hydrated. To fit this skin even better, a product of this type needs gentle, highly compatible ingredients that target redness while providing strong antioxidant protection without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Grape Seed Extract do for sensitive skin?

Grape Seed Extract helps calm sensitive skin by reducing redness and soothing irritation. It is rich in antioxidants that protect the skin barrier and improve moisture levels, making it less likely to react to daily stressors.
Sources: [Skin Pharmacology and Physiology, 2007](https://pubmed.ncbi.nlm.nih.gov/17035721/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35713012/)

### What does Licorice Root Extract do for sensitive skin?

Licorice root extract helps calm redness and ease irritation on sensitive skin through its natural soothing properties. It is unlikely to cause trouble when used as directed, though very safe use is best to avoid any unwanted reactions.
Sources: [Pharmaceutical Biology, 2017](https://pubmed.ncbi.nlm.nih.gov/27650551/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine for sensitive skin. Sensitive skin needs products with calming plant extracts like licorice root and bisabolol to soothe redness and irritation.

### Can I use this serum with retinol, and in what order?

You can use this treatment with a retinol, applying the retinol first and following with this serum in your evening routine. This product is unlikely to irritate sensitive skin, but to get a better fit for this skin type, it needs soothing and calming ingredients like licorice root extract and bisabolol, alongside barrier-supporting components to manage redness effectively.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

You can use this treatment in your evening routine, applying it after your cleanser and soothing toner and before your moisturizer. Sensitive skin needs a treatment of this type to include calming plant extracts like licorice root and bisabolol to soothe redness, along with gentle hydrating ingredients like glycerin.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to cause breakouts or clog pores for sensitive skin, as it has an excellent safety profile without harsh ingredients. Sensitive skin often needs gentle, calming ingredients like licorice root extract and bisabolol, along with lightweight hydrators like glycerin and hyaluronic acid, to soothe redness while keeping pores clear.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — £143.35 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — £25.95 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/uk/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — £16.11 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — £14.99 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/uk/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — £17.91 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/uk/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — £21.00 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Propanediol, Ethylhexyl Olivate, Cetearyl Alcohol, Chlorogenic Acids, Hydrolyzed Sodium Hyaluronate, Lauryl Lactate, Dimethyl Isosorbide, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Tetrahexyldecyl Ascorbate, Ergothioneine, Benzylidene Dimethoxydimethylindanone, Arabidopsis Thaliana Extract, Carnosine, Camellia Sinensis Leaf Extract, Vitis Vinifera Seed Extract Grape Seed Extract, Theobroma Cacao Seed Extract, Curcuma Longa Root Extract, Olea Europaea Fruit Extract Olive Fruit Extract, Euterpe Oleracea Fruit Extract, Trifluoroacetyl Tripeptide-2, Buddleja Officinalis Flower Extract, Coffea Arabica Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Superoxide Dismutase, Ubiquinone, Zingiber Officinale Root Extract, Ceramide Np, Ceramide Ap, Ceramide Eop, Linoleic Acid, Linolenic Acid, Sea Whip Extract, Bisabolol, Tocopherol, Tocopheryl Acetate, Cholesterol, Phytosphingosine, Jojoba Esters, Sodium Pca, Pentylene Glycol, Methyl Gluceth-20, Glycerin, Helianthus Annuus Wax Seed Sunflower Wax Seed, Acacia Decurrens Wax Flower, Lecithin, Sodium Lauroyl Lactylate, Dicetyl Phosphate, Propanediol Dicaprylate Caprate, Polyglycerin-3, Ceteth-20 Phosphate, Diisostearyl Malate, Xanthan Gum, Steareth-2, Acacia Senegal Gum, Carbomer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Dextran, Sodium Hydroxide, Citric Acid, Disodium Edta, Ethylhexylglycerin, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinbetter-science/alto-defense-serum/for/sensitive-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
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- Canada: https://lovi.care/skincare/ca/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
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- Saudi Arabia: https://lovi.care/skincare/sa/p/skinbetter-science/alto-defense-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinbetter-science/alto-defense-serum/for/sensitive-skin