# Sesderma Azelac RU Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Sesderma](https://lovi.care/skincare/uk/brands/sesderma)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin as azelaic acid and 4-butylresorcinol regulate melanogenesis and offer mild keratolytic action, addressing your oily shine by managing oil production and skin tone.
- The presence of niacin and tocopheryl acetate provides general skincare benefits, supporting overall skin health without being overly targeted for your specific concerns.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Liposomal Azelaic Acid, 4-Butylresorcinol, Tranexamic Acid, Niacinamide, Retinol

## What the research says

- Vitamin E in O/W and W/O emulsions significantly increased stratum corneum hydration and enhanced water-binding capacity, with an optimum concentration of 5%. ([Arzneimittel-Forschung, 1998](https://pubmed.ncbi.nlm.nih.gov/9706379/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/))
- 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/))
- Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))

## What reviewers say

Users report this serum effectively brightens the complexion and fades post-acne marks and sunspots, often showing visible results within a few weeks. It is praised for its lightweight texture and ability to control mild acne, though some users note it requires patience for older, deeper pigmentation and can be slightly drying.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Brightens skin tone (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Controls acne (sometimes noted)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Drying effect (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Sesderma Azelac RU a great fit for combination skin?

Sesderma Azelac RU Serum is a great fit for your combination skin because ingredients like azelaic acid and 4-butylresorcinol help manage oily shine and even out your skin tone. It is safe and unlikely to cause irritation since it lacks harsh ingredients, while also supporting overall skin health.

### Which ingredients make this serum a good fit for combination skin?

Azelaic acid and 4-butylresorcinol make this serum a great fit because they manage oil production and help even out your skin tone. They also provide a gentle peeling effect that addresses oily shine without causing irritation.

### What does Azelaic Acid do for combination skin?

Azelaic acid helps calm angry, red spots and smooth out rough or uneven patches on combination skin. It also helps clear pores and keeps skin looking even without causing extra dryness.
Sources: [Postepy Dermatologii I Alergologii, 2023](https://pubmed.ncbi.nlm.nih.gov/38282869/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26355614/)

### What does 4-Butylresorcinol do for combination skin?

4-Butylresorcinol is unlikely to solve the specific concerns of combination skin on its own, because it targets pigment rather than oil balance or dry patches. A product for combination skin needs ingredients that gently clear pores in oily zones while keeping dry areas hydrated and smooth.

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and toning, followed by your moisturizer. Using treatments at night helps keep things simple and safe around sun exposure.

### Can I use this serum with AHA, and in what order?

You can use this serum with AHA, but since both ingredients smooth the skin by renewing the surface, it is best to use them on different nights or space them out to keep your skin calm and avoid irritation.

### How often should I use this serum?

Apply this serum in your evening routine once a week to start, and you may carefully use it more often if your skin tolerates it well and shows good results.

### Can this serum clog pores, cause breakouts or purging for combination skin?

Sesderma Azelac RU Serum is unlikely to clog pores or cause breakouts on combination skin because it is safe for your skin with no risks of irritation. It helps manage oil production and skin tone without harsh ingredients.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — £24.20 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/uk/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — £248.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — £30.37 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — £14.80 at Amazon

## Where to buy

- Amazon.co.uk: £26.27 (https://www.amazon.co.uk/dp/B00987RKWW?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £38.70 (https://www.notino.co.uk/sesderma/azelac-ru/p-514983/)
Prices checked 10 Oct – 4 Nov 2026.

## Ingredients

Water, Propylene Glycol, Alcohol, Peg Ppg-20 6 Dimethicone, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, 4-Butylresorcinol, Azelaic Acid, Retinol, Ascorbyl Glucoside, Niacin, Undecylenoyl Phenylalanine, Glycyrrhetinic Acid, Diacetyl Boldine, Citronellyl Methylcrotonate, Sodium Oxalate, Parfum, Carbomer, Xanthan Gum, Tocopheryl Acetate, Polysorbate 20, Bht, Ethylhexylglycerin, Sodium Hydroxide, Caprylic Capric Triglyceride, Sodium Chloride, Bha, Hydrochloric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/combination-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/sesderma/azelac-ru-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/sesderma/azelac-ru-serum/for/combination-skin
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- Italy: https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/sesderma/azelac-ru-serum/for/combination-skin
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- Canada: https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/combination-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/combination-skin