# REJURAN DUAL EFFECT AMPOULE for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [REJURAN](https://lovi.care/skincare/uk/brands/rejuran)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and treatment for your combination skin, as hyaluronic acid and niacinamide hydrate and improve skin tone, with niacinamide also helping with seboregulation. Blackberry leaf extract and calendula extract provide additional soothing benefits, which are generally supportive for your skin type.
- While the product offers general skincare benefits like hydration and soothing, it lacks targeted ingredients to specifically address your main concern of oily shine.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Bisabolol and Aloe Barbadensis Leaf Juice.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- A blackberry and dill extract combination synergistically increased skin elasticity and induced elastogenesis compared to each ingredient alone and placebo. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32583541/))
- Tropical highland blackberry juice reduced UVB-mediated DNA damage and increased apoptosis in human epidermal keratinocytes and a reconstituted skin equivalent model. ([Photochemistry and Photobiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23711186/))
- Strawberry and blackberry crude extracts, anthocyanin-enriched fractions, and proanthocyanidin-enriched fractions demonstrated anti-inflammatory effects through ROS reduction, gene expression inhibition, and NO suppression, while anthocyanin fractions promoted fibroblast migration in vitro. ([Food Research International, 2019](https://pubmed.ncbi.nlm.nih.gov/31108769/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Calendula officinalis extract cream significantly improved skin hydration and firmness (reflected in significant changes in R0 and R6 parameters) in 21 healthy human volunteers compared to a base cream. ([Acta Poloniae Pharmaceutica, 2011](https://pubmed.ncbi.nlm.nih.gov/21928714/))
- Treatment with standardized extract of Calendula officinalis L. led to a shorter epithelization time and faster healing speed compared to mineral oil in patients with acute skin loss wounds of the hand and fingers healing by secondary intention. ([Tissue Barriers, 2022](https://pubmed.ncbi.nlm.nih.gov/34674610/))
- Topical administration of Calendula provides weak evidence of effectiveness in acute and chronic wounds compared to standard treatments based on a narrative review of available trials. ([Wounds, 2008](https://pubmed.ncbi.nlm.nih.gov/25941793/))

## Why other moisturizers fit combination skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Gluconolactone chemical peels lower skin pH and transepidermal water loss while demonstrating seboregulatory properties in 16 female subjects. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335807/))

## What reviewers say

This ampoule is widely praised for delivering the "glass skin" look, with users reporting immediate improvements in hydration, radiance, and skin texture. It is particularly favored by those with aging or damaged skin for its ability to smooth fine lines and repair the skin barrier using its signature salmon DNA (PDRN) formula, though its high price point is a common contention.

- Liked: Instant Glow (mostly mentioned)
- Disliked: High price point (mostly mentioned)
- Liked: Deep Hydration (often mentioned)
- Liked: Texture Smoothing (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Fast Absorption (sometimes noted)
- Liked: Soothing & Repair (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Heavy/Sticky finish (rarely noted)
- Disliked: Not hydrating enough (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Rejuran Dual Effect Ampoule work for combination skin?

This ampoule works moderately well for combination skin because it hydrates dry areas and calms the skin with soothing extracts, but it lacks targeted ingredients to control oily shine. To work best for this skin type, a product needs effective hydrating and oil-controlling ingredients like niacinamide and ceramides that balance moisture without adding excess oil.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for combination skin?

Hyaluronic acid and niacinamide make this serum a good fit by hydrating your skin and balancing oil, while blackberry leaf and calendula extracts calm it. A moisturizing treatment for combination skin also needs ingredients that target oily shine, provide effective hydration without extra oiliness, and use ceramides to support the skin barrier.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Blackberry Leaf Extract do for combination skin?

Blackberry Leaf Extract helps hydrate and smooth combination skin by supporting moisture balance in both dry and oily areas. It is unlikely to clog pores and may help keep your skin feeling soft throughout the day.

### What does Licorice Extract do for combination skin?

Licorice extract helps calm redness and balances uneven skin tone for combination skin. It also protects skin from daily oxidative stress and helps soothe irritated areas.
Sources: [Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/), [The Journal of Dermatological Treatment, 2003](https://pubmed.ncbi.nlm.nih.gov/14522625/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening keeps the routine simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying it right before your retinol in the evening. Using a soothing, hydrating treatment with ingredients like ceramides and hyaluronic acid helps calm your skin and may lower the dryness and irritation often caused by retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. It is safe for your skin, though a product for combination skin also needs targeted ingredients to control oily shine.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin, as it contains no harsh ingredients and includes soothing components like bisabolol and aloe vera. However, because it lacks targeted ingredients for oily shine, combination skin may need products that help control excess oil.

### Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, as it has a very good safety profile and lacks harsh ingredients. However, because the skin around the eyes and on parts of the body can be quite thin, a product for this skin needs gentle hydration and soothing ingredients to protect against irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/uk/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/combination-skin) — High fit — £18.40 at Amazon
- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/uk/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/combination-skin) — High fit — £24.31 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/uk/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/combination-skin) — High fit — £34.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — £30.37 at Amazon
- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/uk/p/pyunkang-yul/deep-cleansing-oil/for/combination-skin) — Superior fit — £23.92 at Amazon

## Where to buy

- Amazon.co.uk: £41.00 (https://www.amazon.co.uk/dp/B09Z5N7KYD?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Blueberry Fruit Extract, Morus Nigra Fruit Extract, Peg-6, Glycerin, Water, Hyaluronic Acid, Niacinamide, Dipropylene Glycol, Butylene Glycol, 1,2-Hexanediol, Carbomer, Gerotine Hydrolyzed Dna, Hydrolyzed Dna, Xanthan Gum, Polysorbate 20, Adenosine, Tocopheryl Acetate, Bisabolol, Arbutin, Ethylhexylglycerin, Caprylyl Glycol, Hexylene Glycol, Trehalose, Urea, Serine, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Pullulan, Disodium Phosphate, Potassium Phosphate, Squalane, Hydrogenated Lecithin, Ceramide Np, Oleic Acid, Inulin Lauryl Carbamate, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/rejuran/dual-effect-ampoule/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/combination-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/rejuran/dual-effect-ampoule/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/rejuran/dual-effect-ampoule/for/combination-skin
- France: https://lovi.care/skincare/fr/p/rejuran/dual-effect-ampoule/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/rejuran/dual-effect-ampoule/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/rejuran/dual-effect-ampoule/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/rejuran/dual-effect-ampoule/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/rejuran/dual-effect-ampoule/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/rejuran/dual-effect-ampoule/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/rejuran/dual-effect-ampoule/for/combination-skin