Perricone MD Rebalancing Elixir for acne-prone skin
Cannabidiol
Mushroom Complex
Cherimoya Fruit Extract
Capryloyl Glycine
Sodium Pca
High
- HighCombination Skin Fit
- HighEffectiveness
- HighSafety
A great choice for acne-prone skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your combination skin, this product effectively mattifies and controls oil production with capryloyl glycine and sodium bicarbonate, while the anti-inflammatory and sebum-regulating properties of Cannabidiol and Annona Cherimola Fruit Extract offer moderate benefits for your acne, blemishes, and breakouts.
- Ganoderma Lucidum Stem Extract and Grifola Frondosa Fruiting Body Extract further support skin balance and hydration, contributing to overall skin health.
- The formula is safe for your acne-prone skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.5Overall rating based on 800+ reviewsMost users find it provides lightweight hydration that absorbs quickly without feeling heavy, leading to improved skin balance and texture. A moderate number of users feel the product is too expensive for the results, and a low number dislike the natural scent or do not see dramatic anti-aging effects.
Highlights
Soothes sensitive skin Mostly Mentioned
- “soothed irritation instantly”
- “no stinging on application”
- “relief was real”
Lightweight hydration Often Mentioned
- “absorbs super quickly”
- “skin feels hydrated not oily”
- “lightweight moisture boost”
- “perfect for oily/combo skin”
Good for layering Sometimes Noted
- “makeup went right over it”
- “great base for serums”
- “didn't pill under moisturizer”
- “compatible with hyaluronic acid”
Improves skin texture Sometimes Noted
- “softening effect overall”
- “skin shines bright”
- “balanced my pH”
- “smooths texture perfectly”
Expensive for results Sometimes Noted
- “doesn't justify the price”
- “very expensive for a toner”
- “expected more for the cost”
- “pricey investment”
Not a miracle worker Rarely Noted
- “didn't do miracles”
- “just okay hydration”
- “didn't see major changes”
- “good but not amazing”
Product availability issues Rarely Noted
- “hard to find stock”
- “range has been discontinued”
- “replaced by new line”
- “out of stock everywhere”
Unpleasant natural scent Rarely Noted
- “organic almost gamey scent”
- “smells like mushrooms”
- “scent lingers slightly”
- “weird natural smell”
Sources: lovi.care, perriconemd.com, macys.com, influenster.com, lookfantastic.com, menstylefashion.com, and more
Questions and answers
What makes Perricone MD Rebalancing Elixir a great fit for acne-prone skin?
Perricone MD Rebalancing Elixir is a great fit for acne-prone skin because it controls oil and mattifies the skin with capryloyl glycine and sodium bicarbonate, while Cannabidiol and Cherimoya Fruit Extract calm breakouts. A mushroom complex further helps balance and hydrate the skin safely without irritation.
Which ingredients make this elixir a good fit for acne-prone skin?
Cannabidiol, cherimoya fruit extract, capryloyl glycine, and sodium bicarbonate make this elixir a great fit by helping control oil and calm breakouts on acne-prone skin. The mushroom complex further supports skin balance and hydration, and the formula is unlikely to cause irritation.
What does Cannabidiol do for acne-prone skin?
Cannabidiol helps calm acne-prone skin by reducing inflammation and balancing oil production. It is unlikely to cause irritation and may help soothe redness and breakouts.
The Journal of Clinical Investigation, 2014Experimental Dermatology, 2016
What does Mushroom Complex do for acne-prone skin?
Mushroom Complex helps calm oily and breakout-prone skin by soothing redness and irritation. It also provides antioxidant support to protect the skin from everyday stress, though a product for this skin type typically needs added blemish-clearing ingredients like salicylic acid or niacinamide to fully clear pores.
Archives of Dermatological Research, 2025Journal of Drugs in Dermatology, 2013
Where does this elixir go in a skincare routine for acne-prone skin?
This treatment goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Some treatments can also be used in the morning or twice a day.
Can I use it with retinol, and in what order?
You can use this treatment with retinol by applying the retinol first and following with this product, or by using them on alternate nights to keep your skin calm and clear. This approach helps manage breakouts while keeping your skin balanced and hydrated without irritation.
How often should I use this elixir?
This treatment is applied in the evening as part of your routine. It helps control oil and calm breakouts while keeping your skin balanced and hydrated.
Can it clog pores, cause breakouts or purging for acne-prone skin?
This treatment is unlikely to clog pores, cause breakouts, or lead to purging on acne-prone skin. It is very safe for this skin type and helps control oil production while calming blemishes without any harsh ingredients.
Journal of Cosmetic Dermatology, 2023Journal of the American Academy of Dermatology, 2024
Is this elixir fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical application of an anti-aging gel containing EPA and CBD reduced inflammatory agents, decreased crow's feet and fine line wrinkle volume, reduced the subepidermal low-echogenic band by 8.8%, and increased skin hydration by 31.2% and elasticity by 25.6% in 33 participants over 56 days compared to baseline.
Journal of Cosmetic Dermatology, 2023Topical nano-cannabidiol cream reduced UV-A-induced epidermal hyperplasia, nuclear DNA base lesions, and mitochondrial DNA deletions compared with vehicle in nineteen participants.
Journal of the American Academy of Dermatology, 2024The addition of Reishi, Maitake, and Lion's Mane extracts to washing gels reduced skin irritation and intracellular free radical production, positively affected skin pH and hydration, and decreased transepidermal water loss compared with a cosmetic base.
Molecules, 2022Daily application of a novel retinol and cannabidiol combination topical improved global skin quality across 13 domains, including visible pores, dehydration, surface roughness, and static and dynamic wrinkles, in 10 patients with facial skin imperfections.
Aesthetic Surgery Journal. Open Forum, 2022Topical application of carboxymethylcellulose/chitosan hydrogel loaded with cannabidiol reduced inflammation and increased collagen production in radiation-combined wound skin injury in mice.
Phytomedicine, 2025Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy.
Journal of Cosmetic Dermatology, 2021Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups.
Dermatology and Therapy, 2023Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment.
The Journal of Dermatology, 2022Topical application of a formulation containing capryloyl glycine 4% significantly decreased hair density, median hair length, and terminal hair density on the forearms compared to placebo in female patients with hypertrichosis after 120 days.
Journal of Cosmetic Dermatology, 2021A novel natural carrier-free assembled gel composed of sodium pyrrolidone carboxylate and baicalin alleviates UVB-induced skin photodamage by scavenging reactive oxygen species, protecting mitochondria, restoring oxidative homeostasis, inhibiting inflammatory responses, and regulating collagen-related proteins.
Biomaterials Advances, 2026
Ingredients
Water, 1,2-Hexanediol, Sodium Pca, Triethyl Citrate, Propanediol, Capryloyl Glycine, Glycerin, Annona Cherimola Fruit Extract, Cannabidiol, Ganoderma Lucidum Stem Extract Mushroom Stem Extract, Grifola Frondosa Fruiting Body Extract, Sodium Bicarbonate, Caprylhydroxamic Acid, Sodium Hydroxide, Citric Acid, Cannabis Sativa Glycereth-8 Esters Seed Oil, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sodium Citrate, Lentinus Edodes Mycelium Extract, Sodium Dehydroacetate, Phenylpropanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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