# Perricone MD Hyaluronic Intensive Moisturizer for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Perricone MD](https://lovi.care/skincare/uk/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by sodium hyaluronate and glycerin for humectant action, complemented by squalane for emollient action, which deeply hydrates and plumps.
- Niacinamide and tetrahexyldecyl ascorbate offer moderate benefits for wrinkles and fine lines by supporting skin hydration and antioxidant protection.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like Bisabolol and Allantoin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Niacinamide, Squalane, Shea Butter, Tetrahexyldecyl Ascorbate

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))

## What reviewers say

Based on a very large amount of data, this oil-free gel-cream is highly favored by users with dehydrated, mature, and combination skin for its ability to deliver deep hydration without feeling heavy or greasy. Many report visibly plumper skin and reduced fine lines, while a minority experienced breakouts or found the moisture insufficient for very dry skin types.

- Liked: Lightweight feel (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Anti-aging effects (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Not for dry skin (rarely noted)
- Disliked: Scent issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD Hyaluronic Intensive Moisturizer one of the best fits for mature skin?

This moisturizer is one of the best fits for mature skin because sodium hyaluronate and glycerin deeply hydrate and plump, while squalane leaves the skin soft. Niacinamide and tetrahexyldecyl ascorbate provide benefits for wrinkles and fine lines by supporting skin hydration and antioxidant protection. It is also unlikely to cause irritation due to the absence of harsh ingredients and the inclusion of soothing agents like bisabolol and allantoin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

Sodium hyaluronate and glycerin deeply hydrate and plump, while squalane softens dry areas. Additionally, niacinamide and tetrahexyldecyl ascorbate help smooth out wrinkles and fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes near the end of your evening routine, right after your treatment and before any heavier creams. It helps lock in hydration and smooth mature skin while keeping irritation very unlikely.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first and following it with this moisturizer. Using a barrier-enhancing moisturizer like this one helps your skin adjust to retinol and reduces the likelihood of dryness or irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your daily routine. Regular application helps deeply hydrate dry skin, smooth out fine lines, and is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has a very low complaint rate for causing breakouts and an excellent safety profile without harsh ingredients.

### Can I use this cream around the eyes or on my body?

Yes, you can use this moisturizing treatment around the eyes and on the body because its ingredients suit thin and general skin well. Regular application of similar creams containing hyaluronic acid and vitamin C derivatives significantly reduces wrinkle depth in the periorbital area while maintaining very good skin tolerance.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol).

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — £14.74 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/uk/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — £61.50 at Amazon
- [Kate Somerville K8 Peptide Intensive Cream](https://lovi.care/skincare/uk/p/kate-somerville/peptide-k8-power-cream/for/mature-skin) — Superior fit — £102.47 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/uk/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — £22.00 at Amazon

## Where to buy

- Amazon.co.uk: £48.80 (https://www.amazon.co.uk/dp/B07GVS1WZW?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: £61.00 (https://www.lookfantastic.com/p/perricone-md-high-potency-classics-hyaluronic-intensive-moisturizer/13033784/)
Prices checked 17 Oct – 5 Nov 2026.

## Ingredients

Water, Dimethicone, Glycerin, Pentylene Glycol, Niacinamide, Butylene Glycol, Caprylic Capric Triglyceride, Ammonium Acryloyldimethyltaurate Vp Copolymer, Butyrospermum Parkii Butter Shea Butter, Squalane, Sodium Hyaluronate Crosspolymer, Benzyl Alcohol, Urea, Tetrahexyldecyl Ascorbate, Bisabolol, Dimethyl Mea, Styrene Acrylates Copolymer, Dimethicone Vinyl Dimethicone Crosspolymer, Carbomer, Sodium Polyacrylate, Phosphatidylcholine, Hydrogenated Lecithin, Citric Acid, Allantoin, Sodium Hyaluronate, Polysilicone-11, Triacetin, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Phenoxyethanol, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Sodium Lactate, Lactic Acid, Serine, Sorbitol, Potassium Sorbate, Sodium Benzoate, Docosahexaenoic Acid, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/hyaluronic-intensive-moisturizer/for/mature-skin