# Perricone MD High Potency Hyaluronic Intensive Hydrating Serum for dry sensitive skin

**Lovi Fit: Superior fit for dry sensitive skin.**
Dry Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Perricone MD](https://lovi.care/skincare/uk/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for dry sensitive skin.

## Why this fit

- Excellent suitability for your dry and sensitive skin as sodium hyaluronate crosspolymer, sodium hyaluronate, and glycerin provide superb humectant action, while ceramide np and phytosphingosine repair the skin barrier.
- Niacinamide further enhances hydration and soothes sensitivity, complementing the plumping and moisturizing effects for dry or flaky skin.
- The product is safe for your skin, containing no harsh ingredients and including soothing components like hyaluronic acid and niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin): Superior (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Niacinamide, Squalane, Ceramide Np, Acetyl Glucosamine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))

## What reviewers say

Users consistently praise this serum for its ability to deliver immediate and deep hydration, often noting that it visibly plumps fine lines and leaves skin feeling exceptionally soft and smooth. While the vast majority find the texture elegant and fast-absorbing, a small minority of users find it slightly sticky or heavy compared to more watery serums.

- Liked: Deep hydration (mostly mentioned)
- Liked: Fast absorbing (often mentioned)
- Liked: Plumps fine lines (often mentioned)
- Liked: Smooths texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Heavy texture (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Scent (rarely noted)
- Disliked: Sticky feel (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD High Potency Hyaluronic Intensive Hydrating Serum one of the best fits for dry sensitive skin?

This serum is an exceptional fit for dry and sensitive skin because sodium hyaluronate crosspolymer, sodium hyaluronate, and glycerin draw in deep moisture, while ceramide NP and phytosphingosine help repair your skin barrier. Niacinamide further boosts hydration and calms irritation, making it gentle and very safe for easily irritated skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Sodium hyaluronate crosspolymer, sodium hyaluronate, and glycerin give this serum superb moisturizing action, while ceramide NP and phytosphingosine help repair the skin barrier. Niacinamide further boosts hydration and soothes sensitivity, making it a great match for dry and sensitive skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### What does Hyaluronic Acid do for dry sensitive skin?

Hyaluronic acid is a great fit for dry, sensitive skin because it brings a large boost in hydration, making the skin feel soft and smooth while improving barrier function. It helps calm tightness and dryness, and is unlikely to cause irritation.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/)

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in the evening routine after your cleanser and soothing toner, followed by a moisturizer. Putting treatments in the evening keeps things simple and helps avoid any extra irritation around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate and soothe your skin before adding your retinoid. This layered approach helps calm sensitivity and supports your skin barrier while you use active ingredients.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in your evening routine. Daily application helps keep dry and sensitive skin hydrated, soft, and calm.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on dry sensitive skin. Its lightweight formula focuses on deeply moisturizing and repairing the skin barrier without heavy, pore-blocking ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes because its gentle, hydrating formula works well on thin skin, though you should avoid getting it directly in your eyes. It is also safe to use on the body, but it is typically reserved for targeted facial care due to the bottle size.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/uk/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/dry-sensitive-skin) — Superior fit — £34.00 at Amazon
- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/uk/p/revision-skincare/hydrating-serum/for/dry-sensitive-skin) — High fit — £133.23 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/uk/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/dry-sensitive-skin) — High fit — £25.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/uk/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — £8.29 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/uk/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — £17.91 at Amazon
- Moisturizer with Sun Protection: [Real Barrier Mild Sun Cream](https://lovi.care/skincare/uk/p/real-barrier/mild-sun-cream/for/dry-sensitive-skin) — Superior fit — £19.01 at Amazon

## Where to buy

- Amazon.co.uk: £58.10 (https://www.amazon.co.uk/dp/B09WZT5N7X?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: £66.40 (https://www.lookfantastic.com/p/perricone-md-hp-hyaluronic-intensive-hydrating-serum-2oz-fg/13156918/)
- Notino: £76.50 (https://www.notino.co.uk/perricone-md/high-potency-classics-intensive-moisturizing-serum-with-hyaluronic-acid/p-16146252/)
Prices checked 14 Oct – 6 Nov 2026.

## Ingredients

Water, Dimethicone, Butylene Glycol, Niacinamide, Acetyl Glucosamine, Squalane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysilicone-11, Cetearyl Olivate, Hdi Trimethylol Hexyllactone Crosspolymer, Polyisobutene, Sorbitan Olivate, Dimethyl Isosorbide, Polysorbate 20, 1,2-Hexanediol, Caprylyl Glycol, Dimethyl Mea, Hydroxyacetophenone, Citric Acid, Ceramide Np, Caprylyl Capryl Glucoside, Sorbitan Oleate, Sodium Gluconate, Spermidine, Silica, Sodium Acetylated Hyaluronate, Sodium Hyaluronate, Phenoxyethanol, Phytosphingosine, Sodium Hyaluronate Crosspolymer, Ethylhexylglycerin, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Glycerin, Disodium Acetyl Glucosamine Phosphate, Sodium Glucuronate, Magnesium Sulfate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/high-potency-hyaluronic-intensive-hydrating-serum/for/dry-sensitive-skin
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