# Perricone MD Cold Plasma Plus+ Sub-D/Neck for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Perricone MD](https://lovi.care/skincare/uk/brands/perricone-md)
Category: [Sunscreens and SPF moisturizers](https://lovi.care/skincare/uk/best/sunscreens)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best sunscreens for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by niacinamide and tetrahexyldecyl ascorbate, which offer antioxidant activity and melanogenesis regulation, complementing the targeted benefits for wrinkles and fine lines from Tetrahexyldecyl Ascorbate and Acetyl Tetrapeptide-9 that promote collagen synthesis and skin firming.
- Dimethicone and ethylhexyl methoxycrylene offer excellent moisturizing and sun protection, further enhancing the product's overall efficacy for your skin concerns.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing ingredients like Bisabolol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/oily-acne-prone-skin): High

## Key ingredients

Dmae, Niacinamide, Tetrahexyldecyl Ascorbate, Acetyl Tetrapeptide-9, Glycerin

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Daily application of 3% DMAE facial gel for 16 weeks safely and efficaciously mitigates forehead lines and periorbital fine wrinkles, improves lip shape and fullness and overall aging skin appearance, and increases skin firmness compared to placebo. ([American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/))
- A gel containing 3% 2-dimethylaminoethanol (DMAE) increased skin firmness, demonstrated by increased shear wave velocity in 30 volunteers compared to a formulation without DMAE. ([Skin Research and Technology, 2002](https://pubmed.ncbi.nlm.nih.gov/12236885/))
- A DMAE-based formulation increased dermal and collagen fiber thickness in hairless mice and enhanced stratum corneum water content in human forearm skin compared to control formulations, without significantly modifying mechanical properties. ([Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Based on a very large amount of data, users frequently report visible improvements in skin texture and firmness along the jawline and neck, describing the skin as smoother and more hydrated. A significant number of reviewers consistently complain about a strong, unpleasant scent often compared to pickles or fish, and some experience issues with the product pilling under makeup.

- Disliked: Unpleasant smell (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Visibly tightens and firms (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Liked: Lightweight and absorbent (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Caused irritation (rarely noted)
- Disliked: Pilling or flaking (rarely noted)

## How to apply

- Apply this moisturizing sunscreen daily in your AM routine. Reapply every two hours if you are staying outdoors.
- Use this product as the final step in your morning routine after applying your moisturizer.
- Smooth an even layer over your face and neck, making sure to avoid rubbing too hard.
- Apply this moisturizing sunscreen on completely dry skin after your moisturizer has fully absorbed.
- Avoid direct contact with your eyes and do a patch test before your very first use.
- Video: https://storage.pora.ai/53e9a436d82fca2a189dd08aa21de2fd.mp4

## Questions and answers

### What makes Perricone MD Cold Plasma Plus+ Sub-D/Neck one of the best fits for mature skin?

This product is one of the best fits for mature skin because it combines ingredients like niacinamide and tetrahexyldecyl ascorbate to protect against damage while smoothing out wrinkles and fine lines. It also provides deep moisture and sun protection to keep your skin looking firm and healthy.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this cream a good fit for mature skin?

Tetrahexyldecyl ascorbate and acetyl tetrapeptide-9 make this cream a great fit because they help firm the skin and smooth out lines, while niacinamide helps brighten it. Dimethicone also keeps the skin soft and moisturized, and bisabolol helps keep it calm and comfortable.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does DMAE do for mature skin?

DMAE helps make mature skin feel firmer and smoother while lessening the look of fine lines and wrinkles. Daily use of this ingredient is generally safe and supports a more youthful appearance over time, though it is unlikely to change your skin's basic mechanical properties.
Sources: [American Journal of Clinical Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/15675889/), [Die Pharmazie, 2009](https://pubmed.ncbi.nlm.nih.gov/20095140/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this cream go in a skincare routine for mature skin?

This cream goes in the morning routine as a moisturizer and sunscreen step. It helps keep skin soft and protected while smoothing fine lines.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the moisturizer during your morning routine as an SPF step, or by using it after your treatment in the evening. Using a moisturizing product alongside retinol helps support the skin barrier and reduces the likelihood of irritation during treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31322804/)

### How often should I use this cream?

You can use this moisturizing spf every morning as the final step of your daytime routine. Using it daily helps protect your skin from the sun while keeping it smooth and firm.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to cause irritation or breakouts on mature skin, thanks to a very safe formula that avoids harsh ingredients and includes soothing bisabolol.

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol).

## Alternatives for mature skin

- [Purito Daily Soft Touch Sunscreen](https://lovi.care/skincare/uk/p/purito/daily-soft-touch-sunscreen/for/mature-skin) — Superior fit — £9.99 at Amazon
- [Eucerin Sun Fluid Anti-Age SPF 50](https://lovi.care/skincare/uk/p/eucerin/photoaging-control-sun-fluid-spf-50/for/mature-skin) — High fit — £18.40 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — £38.50 at Amazon

## Where to buy

- Amazon.co.uk: £123.00 (https://www.amazon.co.uk/dp/B0862RV8F5?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £133.00 (https://www.notino.co.uk/perricone-md/cold-plasma-plus-neck-chest-firming-cream-for-the-neck-and-decolletage/p-16069906/)
Prices checked 17 Oct – 3 Nov 2026.

## Ingredients

Water, Dimethicone, Cyclopentasiloxane, Glycerin, Niacinamide, Ethylhexyl Methoxycrylene, Pentylene Glycol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyester-8, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Tetrahexyldecyl Ascorbate, Thioctic Acid, Acetyl Tetrapeptide-9, Diethylhexyl Syringylidenemalonate, Hydrogenated Lecithin, Bisabolol, Xanthan Gum, Hydrogenated Phosphatidylcholine, Mannitol, Benzyl Alcohol, Stearic Acid, Isohexadecane, Polysilicone-11, Polysorbate 60, Sorbitan Isostearate, Caprylic Capric Triglyceride, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Aluminum Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus-sub-d-neck/for/mature-skin