# Paula's Choice RESIST Super Antioxidant Concentrate Serum for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Paula's Choice](https://lovi.care/skincare/uk/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by the superb concentration of antioxidants like Tetrahexyldecyl Ascorbate and Tocopherol, offering maximum beneficial effects for wrinkles and fine lines.
- The serum also offers excellent antioxidant protection and skin tone evening due to high concentrations of Tetrahexyldecyl Ascorbate and Ferulic Acid, which shield your skin from environmental stressors and brighten your complexion.
- There are no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients, and the presence of soothing ingredients like Beta-Glucan and Glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Tetrahexyldecyl Ascorbate, Ceramide Np, Palmitoyl Tripeptide-5, Superoxide Dismutase

## What the research says

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- A topical antioxidant solution of 15% L-ascorbic acid, 1% alpha-tocopherol, and 0.5% ferulic acid provides significant photoprotection against solar-simulated UV radiation in human skin compared to its vehicle. ([Journal of the American Academy of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18603326/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))

## What reviewers say

Based on limited data, users with dry, mature, or sensitive skin frequently praise this serum for its rich, hydrating texture that functions as a barrier against environmental stress, often noting a visible "glow" and improved plumpness. Users with combination or oily skin often find the silicone-heavy formula too occlusive, leading to a greasy finish or potential congestion.

- Liked: Deeply hydrating (often mentioned)
- Disliked: Greasy/shiny finish (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Soothes sensitive skin (sometimes noted)
- Disliked: Heavy silicone feel (sometimes noted)
- Disliked: Slow absorption (sometimes noted)
- Liked: Protective packaging (rarely noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice Super Antioxidant Concentrate Serum one of the best fits for mature skin?

This serum is one of the best fits for mature skin because it contains superb concentrations of antioxidants like Tetrahexyldecyl Ascorbate and Tocopherol that help smooth wrinkles and fine lines. It also brightens your complexion and shields your skin from environmental stressors without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin due to high concentrations of Tetrahexyldecyl Ascorbate and Tocopherol, which help smooth out fine lines and wrinkles. It also features Ferulic Acid and soothing ingredients like Beta-Glucan and Glycerin, which brighten your complexion and protect against environmental stress without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Where does this serum go in a skincare routine for mature skin?

Apply this treatment serum in the evening as part of your routine for simplicity and extra safety around sun exposure. It helps smooth fine lines and brighten your complexion while shielding your skin from environmental stressors.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first in your evening routine and following with your retinol. This approach helps smooth fine lines while minimizing potential irritation when your skin is well-adjusted.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### How often should I use this serum?

Apply this serum in your evening routine as part of your regular skincare steps. This helps smooth fine lines and brighten your skin over time with minimal risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts for mature skin, as it lacks harsh ingredients and includes soothing components like beta-glucan and glycerin.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — £143.35 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — £25.95 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/uk/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — £372.06 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — £38.50 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Cyclopentasiloxane, Dimethicone, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Ceramide Np, Tocotrienols, Tocopherol, Ubiquinone, Thioctic Acid, Magnesium Ascorbyl Phosphate, Ferulic Acid, Beta-Glucan, Superoxide Dismutase, Epigallocatechin Gallate, Ergothioneine, Glutathione, Xanthophyll, Glycine Soja Seed Extract, Glycerin, Arctostaphylos Uva-Ursi Leaf Extract, Lupinus Albus Seed Extract, Curcuma Longa Root Extract, Palm Oil, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin (this page)
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