# Osmosis Skincare Renew Level 4 Vitamin A Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: Osmosis Skincare
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your combination skin and acne-prone concerns is provided by retinal and niacinamide, which regulate oil production and promote skin renewal to reduce inflammation and breakouts. Palmitoyl tripeptide-38 and lactic acid further support skin rejuvenation by minimizing fine lines and improving texture. The formula is safe for your skin, featuring soothing ingredients like niacinamide and beta-glucan, with no harsh or irritating components.
- The inclusion of thioctic acid and fulvic acid offers antioxidant benefits, complementing the primary actives for comprehensive skin health.
- This product is safe for your skin, as it contains no prohibited or harsh ingredients and includes soothing agents like niacinamide and beta-glucan.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/oily-acne-prone-skin): High

## Key ingredients

Vitamin A, Niacinamide, Retinal, Palmitoyl Tripeptide-38, Sodium Hyaluronate

## What the research says

- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Treatment with a cream containing 5% alpha-lipoic acid for 12 weeks reduces skin roughness by an average of 50.8% compared to 40.7% with placebo in women with photoaged facial skin. ([The British Journal of Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14616378/))
- Application of 5% cubosomal alpha lipoic acid gel twice daily for 6 months significantly improved global aesthetic scores and increased epidermal thickness compared to placebo in 20 aging female faces. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/27873449/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on limited data, users find this serum to be a highly effective anti-aging treatment that smooths fine lines and refines skin texture without causing irritation. It is frequently praised for its gentle, hydrating formula and its ability to deliver a noticeable glow. Some users report peeling if the product is overused, and a moderate number find the price point to be high.

- Liked: Gentle & non-irritating (mostly mentioned)
- Liked: Effective anti-aging (often mentioned)
- Liked: Improves texture & tone (often mentioned)
- Liked: Hydrating formula (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Dispenser issues (rarely noted)
- Disliked: Peeling if overused (rarely noted)
- Disliked: Yellow tint (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Osmosis Renew Level 4 a great fit for acne-prone skin?

Osmosis Renew Level 4 is a great fit because retinal and niacinamide help regulate oil production and calm inflammation to reduce breakouts. The formula also features soothing beta-glucan and gentle ingredients that keep the skin safe without harsh irritation.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for acne-prone skin?

Retinal and niacinamide make this serum a great fit for acne-prone skin because they help control oil and calm inflammation to reduce breakouts. Niacinamide and beta-glucan also soothe the skin, while ingredients like lactic acid improve texture.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Vitamin A do for acne-prone skin?

Vitamin A helps clear acne-prone skin by keeping pores clear and reducing swelling. It works by targeting skin cell growth and calming inflammation.
Sources: [Journal of Drugs in Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35816067/), [Dermatology and Therapy, 2017](https://pubmed.ncbi.nlm.nih.gov/28585191/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Putting it on at night helps keep your skin safe from sun sensitivity while the ingredients work to calm breakouts and smooth texture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/)

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C, but it is best to apply vitamin C in the morning and save this treatment for your evening routine to keep your skin calm and avoid irritation. Using them at different times of day helps your skin handle the potent active ingredients safely while still getting all the antioxidant benefits.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this serum?

This serum is a great fit for your acne-prone skin and is used in the evening as part of your routine. Start using it once a week, and if your skin feels calm and smooth, you may carefully use it more often.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for acne-prone skin because retinal and niacinamide help regulate oil production and calm inflammation, making breakouts less likely. It is generally safe for your skin with soothing ingredients like niacinamide and beta-glucan, though mild peeling may happen if it is overused.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (benzyl alcohol) and drying alcohol (alcohol denat).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — £24.20 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — £143.35 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/uk/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — £8.13 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/uk/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — £11.90 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Niacinamide, Phosphatidylcholine, Glycerin, Asiaticoside, Cyclodextrin, Caprooyl Tetrapeptide-3, Chlorella Vulgaris Extract, Epilobium Angustifolium Stem Extract Flower Leaf, Palmitoyl Tripeptide-38, Sodium Hyaluronate, Lactic Acid, Thioctic Acid, Fulvic Acid, Dimethyl Sulfone, Retinal, Beta-Glucan, Hydroxyproline, Grapefruit Peel Oil, Santalum Austrocaledonicum Oil Wood Sandalwood Oil Wood, Rubus Chamaemorus Berry Seed Oil Cloud Berry Seed Oil, Lonicera Caprifolium Flower Extract Honeysuckle Flower Extract, Lonicera Japonica Flower Extract Honeysuckle Flower Extract, Dextran, Hydroxypropyl Cyclodextrin, Xanthan Gum, Alcohol Denat, Potassium Sorbate, Sodium Hydroxide, Benzyl Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/osmosis-skincare/renew-level-4-vitamin-a-serum/for/acne-prone-skin