# numbuzin Vitamin-Niacinamide Concentrated Pad for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [numbuzin](https://lovi.care/skincare/uk/brands/numbuzin)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for normal skin as niacinamide and ascorbic acid provide antioxidant activity and melanogenesis regulation, but it lacks sufficient humectant and emollient ingredients for optimal hydration and barrier support.
- The formula provides general skincare benefits like hydration and soothing with ingredients such as panthenol, which are supportive but not directly targeted at your main goal of addressing wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Glutathione, Ascorbic Acid, Sodium Hyaluronate, Panthenol

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## Why other serums fit mature skin better

- Topical application of retinol and retinoic acid both increased epidermal thickness and upregulated collagen genes and proteins in human skin, with retinol producing similar histological and molecular changes to retinoic acid alongside a significant reduction in facial wrinkles after 12 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26578346/))

## What reviewers say

Based on a very large amount of data, users primarily utilize these pads to target hyperpigmentation, acne scars, and dullness, with many reporting a noticeable "glass skin" glow and smoother texture after consistent use. While effective for brightening, reactions are mixed regarding hydration; oily and combination skin types often find them refreshing, whereas those with dry or highly sensitive skin occasionally report dryness, tingling, or breakouts.

- Liked: Effective brightening (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Liked: Refreshing and lightweight (sometimes noted)
- Liked: Unique dual-sided pad (sometimes noted)
- Disliked: Packaging leaks (sometimes noted)
- Disliked: Drying for some (rarely noted)
- Disliked: Irritation and breakouts (rarely noted)
- Disliked: Texture dislike (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Numbuzin Vitamin-Niacinamide Concentrated Pad work for mature skin?

This treatment works moderately well for mature skin because niacinamide and ascorbic acid help brighten the skin, though it lacks enough deep hydrating and softening ingredients to smooth out fine lines effectively. Mature skin needs powerful anti-aging ingredients, strong moisturizers, and nourishing oils or peptides to target wrinkles and support the skin barrier.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this treatment a good fit for mature skin?

Niacinamide, glutathione, ascorbic acid, sodium hyaluronate, and panthenol make this treatment a fit for mature skin by providing antioxidant activity and hydration. To work best for mature skin, a product of this type needs rich moisturizing ingredients and targeted anti-aging components that smooth fine lines and support the skin barrier.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Glutathione do for mature skin?

Glutathione helps mature skin by improving moisture, smoothness, and elasticity while reducing wrinkles and age spots. It also protects skin cells from everyday oxidative stress and environmental damage with a very safe profile.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Molecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41900080/)

### Where does this treatment go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Mature skin needs a product of this type to also include rich moisturizing ingredients and firming peptides for better hydration and wrinkle care.

### Can I use this treatment with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol product, or by using them on alternating nights to keep your skin calm. The formula has an excellent safety profile with a low likelihood of irritation, though mature skin also needs rich smoothing hydrators and protective softeners to keep it plump and smooth.

### How often should I use this treatment?

This treatment should be used in your evening routine once a week to start, and people who tolerate it well and see good results may carefully use it more often. A product of this type needs rich moisturizing and barrier-supporting ingredients to properly care for mature skin.

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores or cause breakouts for mature skin, as it has an excellent safety profile without harsh ingredients.

### Is this treatment fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — £143.35 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — £25.95 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/uk/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — £372.06 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — £38.50 at Amazon

## Where to buy

- Amazon.co.uk: £14.29 (https://www.amazon.co.uk/dp/B0C61CJ66L?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: £20.00 (https://www.lookfantastic.com/p/numbuzin-no.5-vitamin-niacinamide-concentrated-pad-x-70/17027867/)
Prices checked 17 Oct – 31 Oct 2026.

## Ingredients

Water, Niacinamide, Dipropylene Glycol, Glycerin, Propanediol, Butylene Glycol, Hydroxyethyl Urea, Diethoxyethyl Succinate, Hydroxyacetophenone, Caprylyl Glycol, Polyglyceryl-10 Laurate, Betaine, Panthenol, Ethylhexylglycerin, Gluconolactone, Sodium Polyacrylate, Ammonium Acryloyldimethyltaurate Vp Copolymer, Sodium Citrate, Citric Acid, Maltodextrin, 1,2-Hexanediol, Gardenia Florida Fruit Extract, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Ascorbic Acid, Pantolactone, Tocopherol, Capryloyl Salicylic Acid, Tranexamic Acid, Tremella Fuciformis Extract Mushroom Extract, Caprylic Capric Triglyceride, Ascorbyl Glucoside, Ubiquinone, Hydrogenated Lecithin, Magnesium Chloride, Alcohol, Glutathione, Polysorbate 80, Calcium Gluconate, Pyridoxine Hcl, Bht, Yeast Extract, Cyanocobalamin, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- France: https://lovi.care/skincare/fr/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/numbuzin/vitamin-niacinamide-concentrated-pad/for/mature-skin