# numbuzin 5 Glutathione Vitamin Concentrated Serum for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [numbuzin](https://lovi.care/skincare/uk/brands/numbuzin)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- This serum offers excellent brightening and evening of skin tone for you due to the presence of niacinamide and glutathione, which effectively treat hyperpigmentation. It also provides relevant benefits for your dry or flaky skin with Panthenol and Sodium Hyaluronate, ensuring adequate hydration.
- The formula is highly suitable for your dry skin, as Butyrospermum Parkii Butter and Ceramide NP work to provide emollient action and repair your skin barrier.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/oily-acne-prone-skin): High

## Key ingredients

Glutathione, Niacinamide, 3-O-Ethyl Ascorbic Acid, Tranexamic Acid, Alpha-Arbutin

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))

## What reviewers say

Based on a very large amount of data, users with dullness, hyperpigmentation, and sensitive skin frequently praise this serum for its ability to fade acne scars and even out skin tone without causing irritation. The majority report a "glass skin" glow and rapid absorption, while a small minority experienced breakouts or found the brightening effects too slow to appear.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Gentle on skin (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Hydrating glow (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Slow results (rarely noted)
- Disliked: Tacky finish (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes numbuzin 5 Glutathione Vitamin Concentrated Serum a great fit for dry skin?

This serum is a great fit for dry skin because it includes panthenol and sodium hyaluronate to provide adequate hydration, alongside shea butter and ceramide NP to repair your skin barrier. It is unlikely to cause any irritation due to the absence of harsh ingredients, and the formula helps brighten and even out your skin tone.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for dry skin?

This serum is a great fit for dry skin because panthenol and sodium hyaluronate ensure adequate hydration, while shea butter and ceramide NP repair your skin barrier. It also helps brighten and even out your skin tone safely with niacinamide and glutathione.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/)

### What does Glutathione do for dry skin?

Glutathione helps dry skin by improving moisture levels and smoothness while keeping the skin barrier strong against daily stress. Topical application of glutathione may also reduce water loss through the skin, helping your face feel softer and more hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/)

### What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in the evening routine, placed after cleansing and before moisturizing, though it may also be used in the morning or twice a day. Applying treatments at night helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first in your evening routine and following with your retinol, as the formula is unlikely to irritate dry skin.

### How often should I use this serum?

This serum is a great fit for your dry skin and is meant to be used in your evening routine. It is unlikely to cause irritation and helps brighten skin tone while providing soothing moisture.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores or cause breakouts for dry skin. The formula avoids harsh or prohibited ingredients that commonly trigger irritation, helping maintain a safe and comfortable experience.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Behenyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — £36.96 at Amazon
- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/uk/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — £32.95 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/uk/p/augustinus-bader/the-serum/for/dry-skin) — Superior fit — £248.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/uk/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — £8.29 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/uk/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — £11.49 at Amazon
- Moisturizer: [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/dry-skin) — Superior fit — £14.74 at Amazon

## Where to buy

- Amazon.co.uk: £16.18 (https://www.amazon.co.uk/dp/B0FZT6DPCD?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £18.10 (https://www.notino.co.uk/numbuzin/no-5-goodbye-blemish-serum-intense-revitalising-serum-to-treat-skin-imperfections/p-16312715/)
- Lookfantastic: £20.00 (https://www.lookfantastic.com/p/numbuzin-no.5-vitamin-serum-30ml/17750357/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Vaccinium Vitis-Idaea Fruit Extract, Butylene Glycol, Niacinamide, Panthenol, Tranexamic Acid, Water, 1,2-Hexanediol, Neopentyl Glycol Dicaprate, Caprylic Capric Triglyceride, Sorbitol, Bifida Ferment Filtrate, Chondrus Crispus Extract, Butyrospermum Parkii Butter, Saccharum Officinarum Extract, Alpha-Arbutin, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Tremella Fuciformis Extract, Pentylene Glycol, Glycerin, 3-O-Ethyl Ascorbic Acid, Alpha Bisabolol, Tromethamine, Ethylhexylglycerin, Adenosine, Hydrogenated Lecithin, Allantoin, Glutathione, Ceramide Np, Beta-Glucan, Dipotassium Glycyrrhizate, Tocopherol, L Ascorbic Acid, Ascorbyl Glucoside, Tocopheryl Acetate, Hydroxypropyl Cyclodextrin, Ubiquinone, Alpha Lipoic Acid, Potassium Hydroxide, Behenyl Alcohol, Carbomer, Xanthan Gum, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin