# numbuz:n No.3 Skin Softening Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [numbuz:n](https://lovi.care/skincare/uk/brands/numbuz-n)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Highly suitable for your normal skin as Bifida Lysate Ferment and Galactomyces Ferment Filtrate provide excellent barrier repair and humectant action, supporting your goal of addressing wrinkles and fine lines.
- The inclusion of squalane and panthenol further enhances skin hydration and resilience, beneficial for maintaining skin smoothness.
- The product is safe for your skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/oily-acne-prone-skin): High

## Key ingredients

Bifida Lysate Ferment, Galactomyces Ferment Filtrate, Niacinamide, Sodium Hyaluronate, Squalane

## What the research says

- Daily application of Galactomyces ferment filtrate-containing skin products for 12 months significantly and cumulatively reversed 11-year facial skin aging parameters of wrinkles, hyperpigmented spots, and roughness, and increased skin hydration in 86 female volunteers. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36769815/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- A combination serum containing galactomyces ferment filtrate, dexpanthenol, and Centella asiatica effectively treated post-acne hyperpigmentation in subjects with colored skin by significantly increasing lightness scores in Fitzpatrick skin type V and reducing the melanin index in Fitzpatrick skin type IV compared to placebo. ([Skinmed, 2021](https://pubmed.ncbi.nlm.nih.gov/33938432/))
- Application of Galactomyces ferment filtrate skin care formula significantly reduced the net values and daily fluctuation of facial pore area, roughness, and redness in young Japanese women. ([Journal of Clinical Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34198790/))
- Galactomyces ferment filtrate promotes epidermal interconnectivity, barrier development, cell adhesion, keratinocyte differentiation and proliferation, and protects cellular bioenergetics against stress in keratinocytes and ex vivo skin explants compared to untreated controls. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38924095/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective at softening and smoothing skin, providing a radiant glow and deep hydration, with many users achieving a 'glass skin' appearance. However, a moderate number of users report breakouts and fungal acne flare-ups, while a low number experience irritation or find the finish sticky. This summary should be definitely taken into account.

- Liked: Softens skin (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Improves radiance (often mentioned)
- Liked: Elegant texture (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Causes irritation (rarely noted)
- Disliked: No results (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes numbuz:n No.3 Skin Softening Serum a great fit for mature skin?

This serum is a great fit for mature skin because its bifida lysate ferment and galactomyces ferment filtrate help repair the skin barrier and smooth out fine lines and wrinkles. Squalane and panthenol further boost hydration and resilience, keeping the skin soft and healthy.
Sources: [Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36769815/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for mature skin?

Bifida Lysate Ferment, Galactomyces Ferment Filtrate, squalane, and panthenol make this serum a great fit because they repair your skin barrier, smooth fine lines, and boost hydration. Daily use of these ingredients helps keep mature skin looking soft and healthy.
Sources: [Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36769815/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Bifida Ferment Lysate do for mature skin?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, which keeps mature skin feeling soft and comfortable. It also provides antioxidant support that may protect against everyday stress, though products for mature skin also need firming and smoothing ingredients like peptides and retinol.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Galactomyces Ferment Filtrate do for mature skin?

Galactomyces ferment filtrate helps smooth and brighten mature skin by reducing wrinkles, dark spots, and roughness while keeping skin well hydrated. Daily use supports long-term skin rejuvenation and helps calm daily redness and pore size changes.
Sources: [Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36769815/), [Journal of Clinical Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34198790/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps the application simple and safe around sun exposure. Ferment filtrates and squalane help smooth mature skin while boosting hydration.
Sources: [Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36769815/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to keep your skin hydrated and smooth while using retinol. This routine helps reduce the dryness and irritation that often come with retinol use.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

You can use this serum in your evening routine, applying it after cleansing and toning and before moisturizing. Daily application helps keep mature skin hydrated and smooth while improving the appearance of fine lines and wrinkles.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum may occasionally cause breakouts, as some reviewers note this effect, but it is unlikely to cause irritation. Its gentle ingredients like squalane and panthenol help keep mature skin hydrated and smooth without harsh additives.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum on the thin skin around your eyes and on your body to help smooth out fine lines and boost hydration. Because the skin in these areas can be quite delicate, the soothing components and lack of harsh ingredients make it very well tolerated.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/uk/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin) — High fit — £18.17 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/uk/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/mature-skin) — Average fit — £34.00 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/uk/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/mature-skin) — Average fit — £18.40 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/uk/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — £22.00 at Amazon

## Where to buy

- Amazon.co.uk: £23.08 (https://www.amazon.co.uk/dp/B0915K6WD3?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £9.80 (https://www.notino.co.uk/numbuzin/no-3-skin-softening-serum-smoothing-serum-for-radiance-and-hydration/p-16312710/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Galactomyces Ferment Filtrate, Butylene Glycol, Methyl Gluceth-20, Water, Niacinamide, Peg-90, 1,2-Hexanediol, Glycerin, Squalane, Alteromonas Extract Ferment, Silk Extract, Goat Extract Milk, Sodium Hyaluronate, Panthenol, Adenosine, Glycereth-26, Xanthan Gum, Polyglyceryl-3 Distearate, Glyceryl Stearate Se, Glyceryl Stearate Citrate, Polyglyceryl-3 Methylglucose Distearate, Carbomer, Tromethamine, Ethylhexylglycerin, Caprylyl Glycol, Tropolone, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuz-n/no-3-skin-softening-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/numbuz-n/no-3-skin-softening-serum/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/numbuz-n/no-3-skin-softening-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/numbuz-n/no-3-skin-softening-serum/for/mature-skin
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- Canada: https://lovi.care/skincare/ca/p/numbuz-n/no-3-skin-softening-serum/for/mature-skin
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