# Medik8 Oxy-R Peptides for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Medik8](https://lovi.care/skincare/uk/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin brightening for your oily skin due to Hydroxyresveratrol and Tetrapeptide-30, which promote even skin tone and address your concerns about oiliness.
- The presence of Gluconolactone and Lactic Acid provides moderate exfoliation and antioxidant effects, offering benefits for acne and blemishes without irritating your skin.
- The formula is safe for your oily skin, featuring soothing ingredients like Hydroxyresveratrol and Glycerin with no harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Oxyresveratrol, Peptides, Sodium Hyaluronate, Lactic Acid, Glycerin

## What the research says

- Application of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid for 12 weeks increased skin lightness (L*-value) and significantly decreased melanin index and erythema index in Korean women. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28512843/))
- Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients. ([The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/))
- Glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene showed no hindrance compared to adapalene monotherapy and provided benefits in reducing complications in 25 subjects with mild-to-moderate acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/))
- Combining 10% gluconolactone chemical peeling with oxybrasion or microneedle mesotherapy increased skin hydration and decreased sebum, pH, and TEWL in twenty-one Caucasian women, with no significant differences between the two methods. ([Skin Research and Technology, 2023](https://pubmed.ncbi.nlm.nih.gov/37357656/))
- Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced UVB-induced skin pigmentation and melanogenic enzyme expression in brown guinea pigs compared to vehicle control, with oxyresveratrol showing the greatest effect. ([Food and Chemical Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21946069/))
- Topical oxyresveratrol microemulsion at 20-30% w/w effectively delayed skin lesion development and protected mice from death compared to untreated controls. ([AAPS PharmSciTech, 2012](https://pubmed.ncbi.nlm.nih.gov/22996670/))
- Encapsulating dihydrooxyresveratrol and oxyresveratrol into nanostructured lipid carriers enhanced photostability, promoted controlled release, facilitated skin penetration, exhibited no cytotoxicity up to 500 µg/mL on human keratinocytes, and effectively reduced melanogenesis in B16F10 cells. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39587280/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## What reviewers say

Based on a very large amount of data, users with hyperpigmentation, melasma, and post-inflammatory erythema (PIE) frequently report visible skin brightening and the fading of dark spots, often noting a smoother texture and "glass-like" glow within weeks. While many experience rapid results, a minority of users report no visible changes or mild breakouts, and the short shelf life of the activated formula is a noted consideration.

- Liked: Fades dark spots (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Gentle formulation (sometimes noted)
- Liked: Rapid results (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Short shelf life (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medik8 Oxy-R Peptides a great fit for oily acne-prone skin?

Medik8 Oxy-R Peptides is a great fit because it brightens your skin and evens out your tone while helping with oiliness. It also provides gentle exfoliation and antioxidant benefits that help manage acne and blemishes without causing irritation, thanks to a safe formula with soothing ingredients.
Sources: [The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit for your oily acne-prone skin because hydroxyresveratrol and tetrapeptide-30 help brighten your skin and even out your tone. Gluconolactone and lactic acid provide gentle exfoliation to help manage breakouts, while glycerin helps keep your skin comfortable and calm.
Sources: [The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/)

### What does Oxyresveratrol do for oily acne-prone skin?

Oxyresveratrol helps oily, acne-prone skin by fighting the bacteria that cause breakouts and calming redness and swelling. It is unlikely to irritate when used properly, and an acne-prone routine also needs oil-controlling and gentle exfoliating ingredients to keep pores clear.
Sources: [Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/36500424/)

### What do Peptides do for oily acne-prone skin?

Peptides help calm oily, acne-prone skin by targeting acne-causing bacteria and reducing redness and swelling. Advanced delivery methods like nanomicelles may also improve how deeply these helpful ingredients sink into the skin.
Sources: [Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/), [Bioorganic Chemistry, 2025](https://pubmed.ncbi.nlm.nih.gov/40925226/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment serum goes in your evening routine, applied after cleansing and before your moisturizer. Putting treatments in the evening keeps things simple and adds extra safety around sun exposure.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first at night, letting it absorb, and then following with this treatment. This helps brighten your skin and manage blemishes while keeping your routine gentle.
Sources: [The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/), [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/)

### How often should I use it?

Use this treatment in your evening routine, applying it once a week at first and carefully working up in frequency if your skin tolerates it well. This gradual approach helps you benefit from the exfoliating ingredients while keeping your skin calm.
Sources: [The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/), [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/)

### Can it clog pores, cause breakouts or purging for oily acne-prone skin?

Medik8 Oxy-R Peptides is unlikely to cause breakouts for oily acne-prone skin because its formula avoids harsh substances and includes gentle exfoliating and soothing ingredients. Some reviewers do occasionally report breakouts, but the product's safety profile is well-suited for your skin type.
Sources: [The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/), [Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30858720/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — £25.95 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — £25.95 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/uk/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — £26.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — £30.37 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — £14.80 at Amazon

## Where to buy

- Amazon.co.uk: £65.00 (https://www.amazon.co.uk/dp/B093R4NDJS?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £65.00 (https://www.notino.co.uk/medik8/oxy-r-peptides-intensive-serum-with-peptides/p-16151739/)
Prices checked 2 Nov – 4 Nov 2026.

## Ingredients

Water, Butylene Glycol, Artocarpus Lakoocha Extract Wood, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium Edta, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
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- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin