# Medik8 Crystal Retinal 10 for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Medik8](https://lovi.care/skincare/uk/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate exfoliation and antioxidant support for your oily skin, with retinal and 3-O-ethyl ascorbic acid helping to refine texture and provide some seboregulation.
- While the formula is generally safe and soothing for your oily skin due to ingredients like Vanilla Planifolia Fruit Extract and Lonicera Japonica Flower Extract, its primary benefits are not directly targeted at your acne, blemishes, and breakouts.
- The product is safe for your skin, with no risks of irritation and the presence of soothing ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Retinal Vitamin A, Sodium Hyaluronate, Squalane, Tetrahexyldecyl Ascorbate, Eclipta Prostrata Extract

## What the research says

- Concurrent treatment with 3-O-ethyl ascorbic acid and cannabigerol in UVB-irradiated human keratinocytes prevents membrane structure alterations, promotes cell survival, enhances antioxidant enzyme activity and GSH- and Trx-dependent systems, reduces lipid and protein oxidative modifications, and exerts anti-inflammatory effects. ([Free Radical Biology & Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39778604/))
- A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- Topical formulations containing ascorbyl tetraisopalmitate, coenzyme Q10, green tea polyphenols, and resveratrol reduced the release of inflammatory cytokines and attenuated inflammatory signs compared to untreated skin and vehicle in 25 Japanese volunteers exposed to sodium dodecyl sulfate. ([European Journal of Pharmaceutics and Biopharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28385617/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of petroleum ether and ethanol extracts of Eclipta alba significantly reduced the time required for hair growth initiation and completion in male albino rats compared to control animals, with the 5% petroleum ether extract showing a greater number of hair follicles in the anagenic phase (69 +/- 4) than the control (47 +/- 13). ([Archives of Dermatological Research, 2008](https://pubmed.ncbi.nlm.nih.gov/18478241/))
- Oral and topical administration of Eclipta prostrata promotes hair growth and enhances the induction of anagen in mice by increasing FGF-7 and decreasing FGF-5 expression. ([Pharmaceutical Biology, 2019](https://pubmed.ncbi.nlm.nih.gov/30757935/))
- Topical application of a polyherbal formulation containing Cuscuta reflexa, Citrullus colocynthis, and Eclipta alba extracts reduced hair growth initiation time to one third and complete hair growth time by 32% in rats compared with control animals. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17524127/))

## Why other serums fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

This high-strength serum is highly regarded by users as an effective step-up for experienced retinoid users, leading to noticeable improvements in skin texture, firmness, and clarity. While it is praised for being gentler than many alternatives and beneficial for anti-aging and congestion, users should be aware of the potential for initial dryness or purging and the product's tendency to stain fabrics.

- Liked: Potent anti-aging (mostly mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Gentle formulation (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Clears congestion (sometimes noted)
- Disliked: Dryness/flaking (sometimes noted)
- Disliked: Initial purging (rarely noted)
- Disliked: Staining potential (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Crystal Retinal 10 work for oily acne-prone skin?

Medik8 Crystal Retinal 10 works moderately well for oily acne-prone skin, as it helps refine texture and control oil, though it does not directly target breakouts. Oily acne-prone skin needs products with ingredients like niacinamide and propolis that manage excess oil and specifically target blemishes.
Sources: [Free Radical Biology & Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39778604/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Retinal and 3-O-ethyl ascorbic acid help refine texture and control oil, while vanilla fruit and honeysuckle extracts help calm oily skin. Oily acne-prone skin needs treatments with ingredients like niacinamide and propolis that directly target blemishes and breakouts while controlling excess oil.
Sources: [Free Radical Biology & Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/39778604/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37571190/)

### What does Retinal do for oily acne-prone skin?

Retinal helps clear clogged pores, reduces bumps and pimples, and helps balance oil production for oily, acne-prone skin. It is generally well tolerated when used regularly as part of an acne skincare routine.
Sources: [Clinical and Experimental Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10564319/), [European Review for Medical and Pharmacological Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25219827/)

### What does Hyaluronic Acid do for oily acne-prone skin?

Hyaluronic acid helps calm oily acne-prone skin by reducing sebum production and lipid synthesis in sebaceous glands. It also supports skin barrier function and improves hydration while helping deliver treatments without causing irritation.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35796638/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. An oily acne-prone skin routine needs ingredients that directly target blemishes, breakouts, and excess oil production.

### Can I use this serum with niacinamide, and in what order?

You can use this serum with niacinamide by applying niacinamide first on clean, dry skin, waiting a few minutes for it to absorb, and then following with this treatment. Oily acne-prone skin needs products that directly target blemishes and breakouts with ingredients like salicylic acid or benzoyl peroxide.

### How often should I use this serum?

This treatment works for your oily acne-prone skin, though other products fit it better. Lovi routines start exfoliating steps once a week, and people who tolerate them well and see good results can carefully use them more often.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This product is unlikely to clog pores, but initial purging is a low possibility for oily acne-prone skin because it contains retinal for moderate exfoliation. Oily acne-prone skin often needs targeted blemish-fighting ingredients and oil-balancing agents that focus directly on breakouts.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (coumarin). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — £25.95 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — £25.95 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/uk/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — £26.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — £30.37 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — £14.80 at Amazon

## Where to buy

- Amazon.co.uk: £69.00 (https://www.amazon.co.uk/dp/B09CKHKP75?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: £75.20 (https://www.lookfantastic.com/p/medik8-crystal-retinal-10/11899387/)
- Notino: £89.00 (https://www.notino.co.uk/medik8/crystal-retinal-10-night-rejuvenating-serum-with-vitamin-a-a-e/p-16088879/)
Prices checked 16 Oct – 3 Nov 2026.

## Ingredients

Water, Caprylic Capric Triglyceride, Glycerin, Isododecane, Cyclodextrin, Cetearyl Olivate, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Cetearyl Alcohol, Sorbitan Olivate, Tocopheryl Acetate, Squalane, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyacetophenone, Rubus Chamaemorus Seed Oil, 3-O-Ethyl Ascorbic Acid, Phenoxyethanol, Hydroxypropyl Methylcellulose, Pentylene Glycol, Daucus Carota Sativa Seed Oil Carrot Seed Oil, Retinal, Sodium Hyaluronate, Tetrahexyldecyl Ascorbate, Alumina, Isostearic Acid, Lecithin, Polyglyceryl-3 Polyricinoleate, Lonicera Japonica Flower Extract Honeysuckle Flower Extract, Lonicera Caprifolium Flower Extract Honeysuckle Flower Extract, Polyhydroxystearic Acid, Disodium Edta, Stearic Acid, Ethylhexylglycerin, Polysorbate 60, Sorbitan Isostearate, Bht, Vanilla Planifolia Fruit Extract Vanilla Fruit Extract, Sodium Polyaspartate, Dipteryx Odorata Extract Tonka Extract Bean Extract, Coumarin, Red 4, Titanium Dioxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/crystal-retinal-10/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/crystal-retinal-10/for/oily-acne-prone-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/medik8/crystal-retinal-10/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medik8/crystal-retinal-10/for/oily-acne-prone-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/crystal-retinal-10/for/oily-acne-prone-skin