# Medicube Zero Pore Cream 2.0 for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Medicube](https://lovi.care/skincare/uk/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this product effectively minimizes pores and controls oily shine with niacinamide and centella asiatica extract, which also provide anti-inflammatory benefits.
- Squalane and panthenol further support hydration and sebum balance, addressing your primary concern for oily shine.
- The formulation is safe for your skin, containing soothing ingredients and avoiding harsh components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Salicylic Acid, Sodium Hyaluronate, Willow Bark Extract, Oil Tree

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- A novel emulsion containing niacinamide, lens esculenta seed extract, and white willow bark extract effectively improved acne, blackheads, and conspicuous facial pores in 30 subjects with oily skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38140770/))
- Topical lycopene-enriched virgin olive oil provides effective pain relief similar to a placebo in patients with burning mouth syndrome, showing a strong placebo effect. ([Journal of Oral Rehabilitation, 2014](https://pubmed.ncbi.nlm.nih.gov/24612248/))

## What reviewers say

Based on a very large amount of data, users with combination and oily skin frequently praise this cream for its ability to balance sebum production while providing deep hydration without a sticky finish. Many report smoother skin texture and a fresh feeling. However, a significant number of reviewers note that visible reduction in pore size is subtle or non-existent despite the product's claims.

- Liked: Excellent hydration (mostly mentioned)
- Liked: Pleasant texture (often mentioned)
- Disliked: Ineffective on pores (often mentioned)
- Liked: Sebum control (sometimes noted)
- Liked: Skin smoothing (sometimes noted)
- Disliked: Strong scent (sometimes noted)
- Disliked: Heavy for some (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes medicube Zero Pore Cream a great fit for combination skin?

Medicube Zero Pore Cream 2.0 is a great fit for your combination skin because it minimizes pores and controls oily shine using niacinamide and centella asiatica extract. Squalane and panthenol further support hydration and keep your skin balanced.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this cream a good fit for combination skin?

This cream is a great fit for your combination skin because niacinamide and centella asiatica extract help minimize pores and control oily shine while calming redness. Squalane and panthenol further support balanced hydration without leaving skin heavy.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Salicylic Acid do for combination skin?

Salicylic acid helps clear clogged pores and balance oily areas while remaining gentle enough for dry spots on combination skin. It reduces breakouts and oiliness effectively with a low likelihood of irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/)

### Where does this cream go in a skincare routine for combination skin?

This treatment goes in your evening routine, after cleansing and before moisturizing. Putting treatments in the evening keeps your routine simple and adds extra safety around sun exposure.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first and following with this moisturizer to help keep your skin calm and balanced. This order helps prevent dryness while supporting hydration and oil control.

### How often should I use this cream?

You can use this treatment in your evening routine, applying it once a week at first and carefully building up frequency if your skin responds well. Niacinamide and squalane help balance oil and hydration, while soothing ingredients make the formula safe for regular use.

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is a great fit for your combination skin and is unlikely to clog pores or cause breakouts because it helps control oily shine and balance sebum. Reviewers rarely report irritation, and the soothing ingredients are very safe for your skin.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — £24.20 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/uk/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — £248.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — £30.37 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — £14.80 at Amazon

## Where to buy

- Amazon.co.uk: £18.94 (https://www.amazon.co.uk/dp/B0DKXDGMLZ?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £32.20 (https://www.notino.co.uk/medicube/zero-pore-cream-2-0-moisturising-facial-cream-to-minimise-pores/p-16359270/)
Prices checked 17 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Niacinamide, Butylene Glycol, Cyclopentasiloxane, Dimethicone, Cyclohexasiloxane, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Polysorbate 80, Squalane, Tocopheryl Acetate, Panthenol, Allantoin, Centella Asiatica Extract, Camellia Sinensis Leaf Extract, Portulaca Oleracea Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Scutellaria Baicalensis Root Extract, Polygonum Cuspidatum Root Extract, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Coptis Japonica Root Extract, Adenosine, Ethylhexylglycerin, Caprylyl Glycol, 1,2-Hexanediol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-cream-2-0/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-cream-2-0/for/combination-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-cream-2-0/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-cream-2-0/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-cream-2-0/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-cream-2-0/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-cream-2-0/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-cream-2-0/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-cream-2-0/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-cream-2-0/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-cream-2-0/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-cream-2-0/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-cream-2-0/for/combination-skin