# Medicube PDRN Pink Peptide Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Medicube](https://lovi.care/skincare/uk/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other moisturizers fit it better.

## Why this fit

- Suitable for normal skin, this serum contains niacinamide and hyaluronic acid to support your skin barrier and provide hydration, which can be beneficial for redness and irritation.
- While glycerin and hyaluronic acid offer moderate moisturizing benefits, the formula lacks specialized ingredients to directly target and significantly reduce your redness and irritation concerns.
- The product is safe for your sensitive skin, as it avoids harsh or prohibited ingredients that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Hydrolyzed Collagen, Sodium Dna

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))

## Why other moisturizers fit sensitive skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A dexpanthenol-containing cream accelerated skin barrier repair, increased stratum corneum hydration, reduced skin roughness, and decreased skin redness compared to vehicle and untreated controls in sodium lauryl sulphate-irritated skin. ([The Journal of Dermatological Treatment, 2002](https://pubmed.ncbi.nlm.nih.gov/19753737/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for delivering intense hydration and a radiant "glass skin" glow, with users frequently reporting immediate improvements in skin plumpness and elasticity. The viscous texture is often noted for its barrier-repairing qualities. A polarizing feature is the distinct scent, described as floral and fishy, which some users find unpleasant.

- Liked: Deep hydration (mostly mentioned)
- Liked: Radiant glow (often mentioned)
- Liked: Smoother texture (often mentioned)
- Liked: Soothing and gentle (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Small quantity (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does the PDRN Pink Peptide Serum work for sensitive skin?

This serum is safe and provides moderate hydration for sensitive skin, though other products fit it better. A moisturizing treatment for this skin type needs extra soothing ingredients to effectively calm redness and irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for sensitive skin?

Niacinamide and hyaluronic acid help support your skin barrier and keep sensitive skin hydrated. To be a better fit for this skin type, a moisturizing treatment needs ingredients that directly soothe and calm redness and irritation without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Hydrolyzed Collagen do for sensitive skin?

Hydrolyzed Collagen helps soothe sensitive skin by calming irritation and keeping it deeply hydrated. It supports the skin barrier so dry, easily upset skin feels much softer and more comfortable with regular use.
Sources: [International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34638528/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26362110/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine after your toner and before your moisturizer. Putting treatments in the evening helps keep your skin safe from sun irritation.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it before your retinol step to help keep your skin hydrated. This product is safe for your sensitive skin because it avoids harsh ingredients that could trigger irritation, though sensitive skin requires a product containing barrier-restoring ceramides and soothing botanicals to truly calm redness.

### How often should I use this serum?

This serum works well in your evening routine, and while you can use it every day, it is unlikely to cause irritation on your sensitive skin. To truly calm redness and irritation, a product for this skin needs soothing plant extracts and barrier-supporting ingredients.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to cause breakouts or clog pores on sensitive skin because it avoids harsh ingredients, though breakouts are a rare complaint among some users. To safely care for sensitive skin prone to congestion, this type of product needs soothing ingredients and lightweight hydrators that keep pores clear while calming irritation.

### Can I use this serum around the eyes or on my body?

This serum is safe to use around the eyes and on the body, as it avoids harsh ingredients that could cause irritation on sensitive areas. Because the skin around the eyes is very thin, a moisturizing treatment used there benefits from extra soothing ingredients to help calm redness and irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/uk/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/sensitive-skin) — High fit — £18.40 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/uk/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/sensitive-skin) — High fit — £34.00 at Amazon
- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/uk/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/sensitive-skin) — High fit — £24.31 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — £14.99 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/uk/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — £17.91 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/uk/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — £21.00 at Amazon

## Where to buy

- Amazon.co.uk: £13.80 (https://www.amazon.co.uk/dp/B0G29RKZ1H?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £23.90 (https://www.notino.co.uk/medicube/pdrn-pink-peptide-serum-firming-facial-serum-with-peptides/p-16329864/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Disodium Edta, Niacinamide, Hydrolyzed Collagen, Sodium Dna, Milt Extract, Copper Tripeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Butylene Glycol, 1,2-Hexanediol, Glycerin, Dipropylene Glycol, Polyglycerin-3, Glyceryl Acrylate Acrylic Acid Copolymer, Pvm Ma Copolymer, Hyaluronic Acid, Ethylhexylglycerin, Glycereth-26, Adenosine, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isopropyl Myristate, Ubiquinone, Caprylyl Glycol, Tromethamine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polyisobutene, Caprylyl Capryl Glucoside, Sorbitan Oleate, Atelocollagen, Salmon Egg Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-serum/for/sensitive-skin