# Medicube PDRN Pink Peptide Ampoule for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Medicube](https://lovi.care/skincare/uk/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for your dry and sensitive skin, as Hyaluronic Acid and Peptide Complex provide excellent hydration and improve elasticity, which are supportive for dry or flaky skin.
- The Salmon Collagen Complex further aids in providing emollient actions beneficial for dry skin.
- The product is safe for your skin due to the absence of prohibited or harsh ingredients, posing no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone

## What the research says

- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine sponge collagen extract formulations increased skin lipids significantly while having no noticeable influence on skin surface pH and only slightly increasing skin hydration. ([European Journal of Pharmaceutics and Biopharmaceutics, 2002](https://pubmed.ncbi.nlm.nih.gov/11777758/))
- Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism. ([BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/))
- Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects. ([Colloids and Surfaces. B, Biointerfaces, 2023](https://pubmed.ncbi.nlm.nih.gov/37574615/))
- Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34206935/))

## What reviewers say

Based on a very large amount of data, users consistently report that this ampoule delivers a "glass skin" effect, providing deep hydration and a noticeable plumping effect that benefits dry and aging skin. While it is widely praised for smoothing texture and soothing sensitive skin, results regarding blemish fading are mixed and take longer to appear.

- Disliked: Deep hydration (mostly mentioned)
- Disliked: Radiant glow (mostly mentioned)
- Disliked: Fast absorption (often mentioned)
- Liked: Noticeable fragrance (sometimes noted)
- Liked: Small volume (sometimes noted)
- Disliked: Soothing and gentle (sometimes noted)
- Liked: Minor breakouts (rarely noted)
- Liked: Slight stickiness (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does medicube PDRN Pink Peptide Ampoule work for dry sensitive skin?

It works moderately well for your dry sensitive skin, as hyaluronic acid and peptide complex provide good hydration and improve elasticity to help with dry flakes, while being safe and unlikely to cause irritation. To fit this skin type best, a moisturizing treatment needs multiple forms of hyaluronic acid, pro vitamin B5, and ceramides for intense hydration, moisture retention, and strong barrier support.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Hyaluronic acid, peptide complex, and salmon collagen complex make this serum a good fit for dry sensitive skin by providing hydration and softening benefits. A product of this type needs multiple forms of hyaluronic acid, pro vitamin B5, and ceramides to intensely hydrate, nourish, and strengthen the skin barrier.
Sources: [Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Salmon Pdrn do for dry sensitive skin?

Salmon PDRN helps calm dry sensitive skin by reducing inflammation and supporting natural tissue repair. It may also improve skin barrier function and boost cell renewal for a smoother and more resilient feel.
Sources: [Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/), [Regenerative Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32757710/)

### What does Salmon Collagen do for dry sensitive skin?

Salmon collagen helps soothe dry sensitive skin by providing a gentle touch of moisture. It works to keep your skin feeling soft and smooth without causing irritation.
Sources: [Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. Putting it in the evening helps keep things simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol. Because your dry and sensitive skin needs products that provide deep moisture and strengthen the skin barrier with ingredients like ceramides and nourishing plant oils, this combination works best when your routine focuses on gentle hydration.

### How often should I use this serum?

You can use this treatment in your evening routine, as this serum is safe for your skin and poses no risk of irritation. A dry and sensitive skin type needs a moisturizing treatment with rich soothing oils and gentle hydrating ingredients to lock in moisture and comfort dry areas.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to cause breakouts, clogged pores, or purging on dry sensitive skin due to its safe ingredients and lack of harsh components. A product for this skin needs gentle hydrators and soothing ingredients like hyaluronic acid and peptides to keep skin smooth and calm.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on your body, as it has a safe makeup that poses no risk of irritation. Hyaluronic acid, peptide complex, and salmon collagen complex help hydrate and smooth thin or dry skin in these areas. To fit your dry and sensitive skin even better, a product of this type needs rich, soothing oils and barrier-supporting lipids.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/uk/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/dry-sensitive-skin) — Superior fit — £34.00 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/uk/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/dry-sensitive-skin) — High fit — £18.40 at Amazon
- [Kiehl's Midnight Recovery Concentrate](https://lovi.care/skincare/uk/p/kiehl-s/midnight-recovery-concentrate/for/dry-sensitive-skin) — High fit — £52.50 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/uk/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — £8.29 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/uk/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — £17.91 at Amazon
- Moisturizer with Sun Protection: [Real Barrier Mild Sun Cream](https://lovi.care/skincare/uk/p/real-barrier/mild-sun-cream/for/dry-sensitive-skin) — Superior fit — £19.01 at Amazon

## Where to buy

- Amazon.co.uk: £13.80 (https://www.amazon.co.uk/dp/B0G29RKZ1H?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Notino: £23.90 (https://www.notino.co.uk/medicube/pdrn-pink-peptide-serum-firming-facial-serum-with-peptides/p-16329864/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone, Ocimum Tenuiflorum, Hyaluronic Acid, Niacinamide, Curcuma Longa Root Extract, Adenosine, Ocimum Sanctum Leaf Extract, Peptide Complex, Rose Pdrn Extract Rosa Damascena Sodium Dna Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin