# Medicube One Day Exosome Shot 2000 for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Medicube](https://lovi.care/skincare/uk/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent suitability for your oily skin due to niacinamide and betaine salicylate, which help regulate sebum and provide mild exfoliation for improved texture and pH.
- Lactobacillus Extracellular Vesicles and Betaine Salicylate promote skin regeneration and chemical exfoliation, offering moderate benefits for your acne, blemishes, and breakouts.
- The formulation is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Adenosine

## What the research says

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))
- Topical application of Bifidobacterium-fermented soy milk extract significantly restored elasticity and viscoelasticity, increased hyaluronic acid content, and improved hydration and thickness in mouse skin, and lessened the decrease in skin elasticity in human skin compared to baseline. ([Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/15608997/))
- Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity. ([International Journal of Pharmaceutics, 2008](https://pubmed.ncbi.nlm.nih.gov/18761396/))
- A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation. ([Chemical & Pharmaceutical Bulletin, 2010](https://pubmed.ncbi.nlm.nih.gov/20190449/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

This ampoule is highly praised for its ability to refine skin texture and minimize pores, leading to smoother skin and a glow. While a tingling sensation from spicules is frequently noted and can be uncomfortable for some, most users experience visible improvements in smoothness and reduced blackheads within weeks. Some users with sensitive skin may experience irritation or dryness.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Prickly/tingling sensation (mostly mentioned)
- Liked: Pore tightening (often mentioned)
- Liked: Blackhead reduction (sometimes noted)
- Liked: Fast results (sometimes noted)
- Disliked: Can be drying (rarely noted)
- Disliked: Skin irritation/breakouts (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Exosome Shot 2000 a great fit for oily acne-prone skin?

Medicube One Day Exosome Shot 2000 is a great fit because it contains niacinamide and betaine salicylate, which help regulate excess oil and gently exfoliate to improve your skin's texture. It also features Lactobacillus extracellular vesicles to promote skin regeneration, offering moderate benefits for breakouts while remaining safe and gentle on your skin.

### Which ingredients make this treatment a good fit for oily acne-prone skin?

Niacinamide and betaine salicylate make this treatment a great fit because they help control oil and gently smooth out texture. Lactobacillus extracellular vesicles and betaine salicylate also support skin renewal to help clear breakouts with a very low risk of irritation.

### What do Lactobacillus Extracellular Vesicles do for oily acne-prone skin?

Lactobacillus extracellular vesicles help calm irritated skin and support the natural skin barrier, which is beneficial for oily acne-prone skin. These ingredients may help reduce redness and soothe breakouts while keeping the skin balanced. A product for oily acne-prone skin needs soothing ingredients and lightweight hydrators to calm flare-ups without feeling heavy.
Sources: [World Journal of Microbiology & Biotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42804019/), [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this treatment go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine, as treatments with active ingredients are placed then for simplicity and extra safety around sun exposure. It is used after cleansing and toning, and before moisturizing.

### Can I use this treatment with retinol, and in what order?

It is best to use this treatment and retinol on alternating nights or times of day rather than together, because combining strong exfoliating ingredients may increase the likelihood of skin irritation. When using both in your routine, apply this treatment first on clean skin, let it absorb fully, and follow with your retinol product on a separate night.

### How often should I use this treatment?

Start using this treatment once a week in your evening routine, and if your skin handles it well and you see good results, you can carefully use it more often. It is a great fit for your oily acne-prone skin because niacinamide and betaine salicylate help regulate oil and gently exfoliate for a smoother texture.

### Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?

This treatment is unlikely to clog pores or cause breakouts for oily acne-prone skin, as its formula offers an excellent fit with ingredients that help regulate oil and provide mild exfoliation. The formulation is safe with no harsh ingredients, though you may experience a tingling sensation which is common with this product type.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — £25.95 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — £25.95 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/uk/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — £26.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — £30.37 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — £14.80 at Amazon

## Where to buy

- Amazon.co.uk: £11.99 (https://www.amazon.co.uk/dp/B0D16L5F2M?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: £23.00 (https://www.lookfantastic.com/p/medicube-one-day-exosome-shot-pore-ampoule-2000-30ml/16858542/)
- Notino: £23.50 (https://www.notino.co.uk/medicube/one-day-exosome-shot-2000-intense-regenerating-serum-to-brighten-and-smooth-the-skin/p-16313459/)
Prices checked 11 Oct – 6 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin