Medicube Collagen Glow Bubble Serum for mature skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

  Scientific Reports, 2024

• The use of cosmetic products containing collagen or its peptides improves the general condition of the skin, reduces wrinkle depth, improves hydration and density, reduces transepithelial water loss, and delays the aging process, while oral bioactive collagen peptides also reduce nail breakage.

  Current Issues in Molecular Biology, 2024

• Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.

  Journal of Cosmetic Dermatology, 2022

• Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.

  International Journal of Molecular Sciences, 2022

• Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.

  Marine Drugs, 2023

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index.

  Journal of Cosmetic Dermatology, 2018

• Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance.

  Dermatology, 2002

• Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients.

  Dermatology, 1999

Ingredients

Water, Glycerin, Propanediol, Water-Soluble Collagen, Glycereth-26, Cetyl Ethylhexanoate, Caprylic Capric Triglyceride, Polyglyceryl-10 Laurate, Niacinamide, 1,2-Hexanediol, Polyglycerin-3, Pentaerythrityl Tetraisostearate, Ammonium Acryloyldimethyltaurate Vp Copolymer, Sodium Lauroyl Glutamate, Gardenia Florida Fruit Extract, Butylene Glycol, Dextrin, Xanthan Gum, Hydroxyethyl Urea, Ethylhexylglycerin, Adenosine, Allantoin, Collagen Extract, Macadamia Ternifolia Seed Oil, Atelocollagen, Desamido Collagen, Hydrogenated Lecithin, Sodium Hyaluronate, Hydrolyzed Elastin, Hydrolyzed Collagen, Caprylyl Glycol, Cholesterol, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sorbitan Laurate, Silica, Retinal, Glutathione, Brassica Campestris Sterols, Thioctic Acid, Ceteth-5, Ceteth-3, Collagen, Collagen Amino Acids, Potassium Cetyl Phosphate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, Sodium Acetylated Hyaluronate, Procollagen, Hydroxypropyltrimonium Hyaluronate, Acetyl Hexapeptide-1, Palmitoyl Tripeptide-5, Disodium Edta, Acetyl Octapeptide-3, Soluble Collagen Crosspolymer, Rosin Hydrolyzed Collagen, Potassium Myristoyl Hydrolyzed Collagen

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.