MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence for combination skin

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Questions and answers

What the research says

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.

  Antioxidants, 2021

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Chitosan-based hydrogels loaded with asiaticoside-rich Centella asiatica extract achieved controlled drug release, skin permeability, antimicrobial activity, and synergistic wound healing effects in an in vitro model.

  International Journal of Molecular Sciences, 2023

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.

  Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016

• A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.

  Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

• An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.

  Aesthetic Plastic Surgery, 2018

Ingredients

Water, Glycerin, Methylpropanediol, Methyl Perfluoroisobutyl Ether, Hydrogenated Polyisobutene, Butylene Glycol Dicaprylate Dicaprate, Caprylic Capric Triglyceride, Methyl Perfluorobutyl Ether, Niacinamide, Cyclopentasiloxane, Cetearyl Alcohol, Cyclohexasiloxane, Palm Oil, Sodium Myristoyl Glutamate, Arginine, Glyceryl Stearate, Peg-100 Stearate, Decyl Glucoside, Betaine, Hydrogenated Lecithin, Hydroxyethyl Urea, Palm Kernel Oil, Dimethicone, Decylene Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Myristic Acid, Hexylene Glycol, Carbomer, Propanediol, Eucalyptus Globulus Leaf Extract, Juniperus Communis Fruit Extract, Butylene Glycol, Dimethicone Vinyl Dimethicone Crosspolymer, Glyceryl Acrylate Acrylic Acid Copolymer, Sodium Hyaluronate Crosspolymer, Urea, Allantoin, Ammonium Lactate, Adenosine, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Laureth-23, Propylene Glycol, Disodium Edta, Buteth-3, Centella Asiatica Extract, Centella Asiatica Leaf Extract, Anthemis Nobilis Flower Water, Argania Spinosa Kernel Oil, Camellia Sinensis Leaf Extract, Magnolia Officinalis Bark Extract, Fructan, Dandelion Root Extract Rhizome, Sodium Benzotriazolyl Butylphenol Sulfonate, Benzyl Glycol, Alcohol, Decyl Alcohol, Tris Tetramethylhydroxypiperidinol Citrate, Hydrolyzed Hyaluronic Acid, Glucose, Desamido Collagen, Hydrolyzed Collagen, Tranexamic Acid, Tributyl Citrate, Trideceth-6, Sodium Polyacrylate, Pentylene Glycol, Hydrogenated Polydecene, Glyceryl Polymethacrylate, Anemarrhena Asphodeloides Root Extract, Chamaecyparis Obtusa Leaf Extract, Asiaticoside, Origanum Vulgare Leaf Extract, Willow Bark Extract, Lactobacillus Soybean Extract Ferment, Cinnamomum Cassia Bark Extract, Scutellaria Baicalensis Root Extract, Portulaca Oleracea Extract, Sorbitan Laurate, Polysorbate 20, Raspberry Ketone, Polysorbate 80, Chondrus Crispus Extract, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, Astaxanthin, Hydrolyzed Elastin, Palmitoyl Tripeptide-5, Madecassoside, Madecassic Acid, Acetyl Hexapeptide-8, Copper Tripeptide-1, Asiatic Acid, Oligopeptide-29, Oligopeptide-32, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide, Palmitoyl Pentapeptide-4, 1,2-Hexanediol, Ethylhexylglycerin, Totarol, Caprylyl Glycol, Ci 42090, Ci 15985, Ci 19140

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.