# Lancôme Rénergie H.P.N. 300-Peptide Cream for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: High · Safety: Concerning.

Page: https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Lancôme](https://lovi.care/skincare/uk/brands/lancome)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as niacinamide can help with oil regulation and glycerin provides hydration, though it may not fully address all your concerns.
- The formulation provides excellent moisturizing and anti-aging benefits through hydrolyzed hyaluronic acid and adenosine, which hydrate and smooth fine lines.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptides, Sodium Hyaluronate, Niacinamide, Hydrolyzed Lupine Protein, Adenosine

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

Based on a very large amount of data, this rich cream is highly recommended for mature and dry skin, effectively plumping, firming, and smoothing without greasiness, leading to a radiant complexion. Some users noted sensitivity to the fragrance and found the price to be high.

- Liked: Luxurious non-greasy texture (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Visible anti-aging results (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant fragrance (sometimes noted)
- Liked: Refillable packaging (sometimes noted)
- Disliked: Heavy for oily skin (rarely noted)
- Disliked: Lack of dramatic results (rarely noted)
- Disliked: Skin irritation (rarely noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Lancôme Rénergie Cream work for combination skin?

Lancôme Rénergie H.P.N. 300-Peptide Cream offers moderate suitability for combination skin, as niacinamide helps balance oil while glycerin and hyaluronic acid provide hydration. However, a product for this skin needs ingredients that reduce oily shine and deliver hydration without feeling heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for combination skin?

Niacinamide helps control oil, and glycerin provides hydration for your combination skin. To fit this skin type even better, products need ingredients that balance oil and reduce shine while keeping skin hydrated without feeling heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Peptides do for combination skin?

Peptides help combination skin by keeping it smooth, supporting firmness, and boosting hydration. They also help reduce the appearance of lines and encourage skin repair, though absorption depends on the formula.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/), [Food & Function, 2019](https://pubmed.ncbi.nlm.nih.gov/31497829/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this cream go in a skincare routine for combination skin?

This moisturizing treatment goes after your cleanser and hydrating toner in the morning routine, or after your evening cleanser and cleansing toner. Combination skin typically needs a lightweight moisturizer and targeted oil-balancing ingredients to keep the T-zone managed while hydrating dry areas.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying it as a moisturizer to help keep your skin hydrated and smooth while using retinol. A moisturizer of this type works best for combination skin when it includes barrier-strengthening ingredients and lightweight hydrators to comfort dry areas while balancing oil.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your morning and evening routine. Regular daily application helps keep your skin hydrated and smooth while supporting your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts for combination skin, though it may not be the most lightweight choice. Combination skin needs a balanced formula with niacinamide and light hydrators that control oil without feeling heavy.

### Can I use this cream around the eyes or on my body?

This moisturizing treatment can be used around the eyes and on the body, but it is an average fit for combination skin. Combination skin needs lightweight hydrators and oil-balancing ingredients like niacinamide and hyaluronic acid to stay smooth without feeling heavy.

### Is this cream fragrance-free and alcohol-free?

It contains fragrance (benzyl alcohol, geraniol, limonene, and parfum) and drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/uk/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — £11.90 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/uk/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — £11.40 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/uk/p/anua/heartleaf-78-soothing-cream/for/combination-skin) — High fit — £29.40 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — £30.37 at Amazon
- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/uk/p/pyunkang-yul/deep-cleansing-oil/for/combination-skin) — Superior fit — £23.92 at Amazon

## Where to buy

- Amazon.co.uk: £62.30 (https://www.amazon.co.uk/dp/B0C63BGNXC?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: £66.75 (https://www.lookfantastic.com/p/lancome-renergie-h.p.n.-300-peptide-cream-50ml/14205251/)
- Notino: £113.00 (https://www.notino.co.uk/lancome/renergie-h-p-n-300-peptide-cream-gift-set-for-women-7134137/p-16360472/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Dimethicone, Cetearyl Alcohol, Theobroma Grandiflorum Seed Butter, Alcohol Denat, Cetearyl Isononanoate, Niacinamide, Glyceryl Stearate, Peg-100 Stearate, Isopropyl Palmitate, Octyldodecanol, Cyclodextrin, Hydrolyzed Lupine Protein, Pisum Sativum Extract, Adenosine, Capryloyl Salicylic Acid, Hydrolyzed Hyaluronic Acid, Hydrolyzed Linseed Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Trisodium Ethylenediamine Disuccinate, Tocopheryl Acetate, Alba Cera, Beeswax, Cire Dabeille, Orbignya Oleifera Seed Oil, Jojoba Butter, Cetearyl Glucoside, Citric Acid, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 60, Potassium Cetyl Phosphate, Sorbitan Isostearate, Tocopherol, Dimethicone Polyglycerin-3 Crosspolymer, Benzyl Alcohol, Geraniol, Limonene, Chlorphenesin, Dipropylene Glycol, Phenoxyethanol, Sodium Benzoate, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/lancome/renergie-h-p-n-300-peptide-cream/for/combination-skin