# La Roche-Posay Toleriane Dermallergo Night Cream for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [La Roche-Posay](https://lovi.care/skincare/uk/brands/la-roche-posay)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing treatment for your oily skin, as glycerin and squalane hydrate and enhance barrier resilience, while niacinamide and salicylic acid provide anti-inflammatory and exfoliating properties to address acne and oiliness.
- Niacinamide helps regulate sebum production, and glycerin acts as a humectant, offering moderate suitability for oily skin and contributing to a smoother complexion.
- The product is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/la-roche-posay/toleriane-dermallergo-night-cream/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Thermal Water, Niacinamide, Squalane, Shea Butter, Allantoin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne. ([The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/))
- Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes. ([Life, 2023](https://pubmed.ncbi.nlm.nih.gov/36983902/))
- A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40545753/))
- A formulation containing vitamin C, biopeptides, hyaluronic acid, and mineralizing water accelerated cell turnover to 17.1 days versus 19.2 days for untreated skin, and reduced crow's-feet, forehead, and nasolabial folds by 9%, 11%, and 5% respectively after 28 days in female subjects. ([International Journal of Cosmetic Science, 2021](https://pubmed.ncbi.nlm.nih.gov/33038010/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))

## What reviewers say

Users with ultra-sensitive, reactive, and allergy-prone skin frequently praise this night cream for its ability to instantly soothe redness and irritation without causing breakouts. While many appreciate the lightweight, gel-cream texture that absorbs quickly, those with extremely dry skin sometimes find it insufficiently moisturizing on its own, requiring an additional layer.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Safe for sensitive skin (often mentioned)
- Liked: Soothing and calming (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Hygienic packaging (sometimes noted)
- Disliked: Not hydrating enough (sometimes noted)
- Disliked: Adverse reactions (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use this AM and PM routine every day to help clear your skin. Always remember to finish with SPF in the morning.
- Apply the moisturizer after your cleanser and toner, right before your SPF during the day.
- Gently press a small amount into your skin and avoid rubbing to keep pores clear.
- Apply on clean, slightly damp skin to help the product absorb better and control oil.
- Avoid the sensitive eye area and do a simple patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes La Roche-Posay Toleriane Dermallergo Night Cream a great fit for oily acne-prone skin?

La Roche-Posay Toleriane Dermallergo Night Cream is a great fit because glycerin and squalane hydrate and protect your skin, while niacinamide helps calm redness and control oil. It is safe for oily skin and is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for oily acne-prone skin?

This cream is a great fit for oily acne-prone skin because glycerin and squalane hydrate and strengthen your skin barrier, while niacinamide helps control oil and calm breakouts. It is very safe for your skin, as it contains no harsh or prohibited ingredients that might cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Thermal Water do for oily acne-prone skin?

Thermal water helps calm oily, acne-prone skin by reducing dryness, stinging, and redness while improving overall skin comfort. It is useful as an extra step in your routine because it supports hydration and makes acne treatments more gentle on the skin.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/), [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348993/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### Where does this cream go in a skincare routine for oily acne-prone skin?

This cream goes in the evening routine as the final step after your treatment, and in the morning routine after your moisturizer and before your SPF. Using it helps hydrate and soothe your oily skin while keeping your skin barrier strong and comfortable.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol, applying the retinol first and following it with this moisturizer. Using a barrier-supporting moisturizer alongside retinol helps reduce dryness and irritation while making your skin more comfortable during treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### How often should I use this cream?

You can use this cream every day as part of your evening routine to keep your oily skin hydrated and balanced. Regular daily application helps improve overall moisture and texture without clogging pores or causing irritation.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this cream clog pores, cause breakouts or purging for oily acne-prone skin?

This cream is unlikely to clog pores or cause breakouts for oily acne-prone skin, as it is safe and free of harsh ingredients that typically cause irritation. Niacinamide also helps regulate oil production while keeping your skin calm.
Sources: [The Medical Journal of Malaysia, 2024](https://pubmed.ncbi.nlm.nih.gov/38553920/)

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes because the gentle formula is safe and well-tolerated on delicate areas. The thin skin on the eyelids and around the eyes benefits from the hydrating ingredients without irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/uk/p/cosrx/advanced-snail-96-mucin-power-essence/for/oily-acne-prone-skin) — Superior fit — £12.21 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/uk/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/oily-acne-prone-skin) — Superior fit — £11.90 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/uk/p/belif/the-true-cream-aqua-bomb/for/oily-acne-prone-skin) — High fit — £32.00 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/uk/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — £26.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — £30.37 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/uk/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/oily-acne-prone-skin) — Superior fit — £27.50 at Amazon

## Where to buy

- Amazon.co.uk: £20.79 (https://www.amazon.co.uk/dp/B09XJWJM44?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: £19.60 (https://www.lookfantastic.com/p/la-roche-posay-toleriane-dermallergo-soothing-cream-for-sensitive-skin-40ml/12932546/)
- Notino: £24.00 (https://www.notino.co.uk/la-roche-posay/toleriane-dermallergo-night-cream-for-sensitive-skin/p-16128915/)
Prices checked 11 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Propanediol, Butyrospermum Parkii Butter, Shea Butter, Pentylene Glycol, Squalane, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Pyridoxine Hcl, Polysorbate 20, Zea Mays Starch, Salvia Miltiorrhiza Root Extract, Allantoin, Glyceryl Acrylate, Acrylic Acid Copolymer, Sodium Hydroxide, Sphingomonas Extract Ferment, Hydroxyacetophenone, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Acetyl Dipeptide-1 Cetyl Ester, Xanthan Gum, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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- United States: https://lovi.care/skincare/p/la-roche-posay/toleriane-dermallergo-night-cream/for/oily-acne-prone-skin
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