# ISDIN Retinal Intense Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [ISDIN](https://lovi.care/skincare/uk/brands/isdin)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your normal skin by utilizing retinaldehyde and bakuchiol to address fine lines and wrinkles through collagen stimulation and desquamation regulation.
- Tocopheryl acetate and ascorbic acid provide supportive antioxidant protection, while melatonin and rosemary leaf extract contribute to soothing effects.
- The formulation is safe for your normal skin, as it lacks harsh ingredients and includes soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Retinaldehyde, Niacinamide, Bakuchiol, Tocopherol, Palmitoyl Tetrapeptide-7

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Topical application of melatonin-based day and night creams significantly reduced crow's feet by 15% and improved skin microrelief, profilometry, tonicity, and dryness in women with moderate-severe skin aging compared to the untreated side after 3 months. ([Clinical, Cosmetic and Investigational Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29416368/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Based on limited data, users highly praise this biphasic night serum for its ability to smooth skin texture and soften fine lines, with many noting it's gentle and non-irritating, even for sensitive skin. While most users experience positive anti-aging results and appreciate its elegant texture, some find the price point to be high and a few report a short shelf life or slow results for deeper wrinkles.

- Liked: Gentle & non-irritating (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Liked: Elegant texture (sometimes noted)
- Liked: Visible anti-aging (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Initial mild irritation (rarely noted)
- Disliked: Short shelf life (rarely noted)
- Disliked: Slow results for some (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does ISDIN Retinal Intense work for mature skin?

ISDIN Retinal Intense works moderately well for mature skin, helping to smooth fine lines and wrinkles. To fit this skin type best, a product of this type needs exceptional safety without irritation risk, highly effective anti-aging ingredients, and rich hydration to support elasticity and moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29416368/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this serum a good fit for mature skin?

This serum works for mature skin by using retinaldehyde and bakuchiol to help smooth out fine lines and wrinkles. To fit this skin type even better, products of this type need a combination of high concentrations of potent antioxidants, peptides, and hydrating ingredients that ensure safety without any risk of irritation while improving firmness and moisture retention.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29416368/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Retinal do for mature skin?

Retinal helps smooth fine lines, improve uneven skin tone, refine texture, and tighten pores on mature skin. It may also boost skin thickness and elasticity over time while keeping irritation low compared to stronger options.
Sources: [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39496127/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30027612/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing. This type of product for mature skin works best when it includes collagen-boosting ingredients and soothing plant extracts.

### Can I use this serum with AHA, and in what order?

It is best to use this serum on separate nights from AHA to help keep your skin calm and prevent excessive dryness or irritation. When you do use both in your routine, apply your AHA after cleansing and follow with a hydrating moisturizer.

### How often should I use this serum?

Apply this treatment serum in your evening routine, starting just once or twice a week to help your skin adjust safely. Mature skin needs products with strong collagen-stimulating ingredients like retinoids and peptides alongside nourishing antioxidants to properly smooth fine lines and keep the skin soft.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, though it may cause mild initial irritation as your skin adjusts. A product of this type needs smoothing ingredients like retinaldehyde and bakuchiol, along with soothing components, to help keep skin clear and soft while targeting fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29416368/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — £143.35 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — £25.95 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/uk/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — £372.06 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — £38.50 at Amazon

## Where to buy

- Amazon.co.uk: £71.32 (https://www.amazon.co.uk/dp/B0BD9DK6SC?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Dimethicone, Dibutyl Adipate, Niacinamide, Isoamyl Laurate, Lauryl Peg Ppg-18 18 Methicone, Glycerin, Propanediol, Dimethicone Vinyl Dimethicone Crosspolymer, Alcohol Denat, Bakuchiol, 2-Hexanediol, Pentylene Glycol, Caprylic Capric Triglyceride, Ethylcellulose, Hydroxyacetophenone, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-T-Butylcyclohexanol, Caprylyl Glycol, Parfum, Sodium Acrylates Crosspolymer-2, Polyacrylate Crosspolymer-6, Vigna Aconitifolia Seed Extract, Tocopheryl Acetate, Tocopherol, Citric Acid, Xanthan Gum, Maltodextrin, Melatonin, Retinal Retinaldehyde, Silica, Disodium Edta, Synthetic Fluorphlogopite, Ci 77891 Titanium Dioxide, Ascorbic Acid, T-Butyl Alcohol, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Palmitoyl Tetrapeptide-7, Tin Oxide, Chrysin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/isdin/retinal-intense-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/isdin/retinal-intense-serum/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/isdin/retinal-intense-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/isdin/retinal-intense-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/isdin/retinal-intense-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/isdin/retinal-intense-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/isdin/retinal-intense-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/isdin/retinal-intense-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/isdin/retinal-intense-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/isdin/retinal-intense-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/isdin/retinal-intense-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/isdin/retinal-intense-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/isdin/retinal-intense-serum/for/mature-skin