# iS Clinical Reparative Moisture Emulsion for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [iS Clinical](https://lovi.care/skincare/uk/brands/is-clinical)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Excellent for your normal skin, this formula leverages Tripeptide-10 Citrulline and Dipalmitoyl Hydroxyproline to effectively target wrinkles and fine lines by promoting collagen synthesis and elasticity.
- Sodium Hyaluronate and Glycerin provide superior hydration, plumping the skin and enhancing its overall texture and suppleness.
- The product is safe for your skin, containing no harsh ingredients and including soothing components like hyaluronic acid and glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Glycerin, Squalane, Beta Vulgaris Root Extract, Superoxide Dismutase

## What the research says

- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Co-culturing mesenchymal stem cells and human keratinocytes on nylon66 electrospun scaffolds loaded with Beta vulgaris extract enhanced cell proliferation and promoted epithelial differentiation compared to mono-cell culturing. ([Materials Science & Engineering. C, Materials for Biological Applications, 2017](https://pubmed.ncbi.nlm.nih.gov/28415512/))
- An aqueous extract of Beta vulgaris reduced lipid accumulation and reactive oxygen species in human HaCaT keratinocyte cells treated with palmitic/oleic acids or hydrogen peroxide. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278345/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))

## What reviewers say

This moisturizer is widely celebrated for its sophisticated, lightweight formula that delivers intense hydration and barrier repair without clogging pores or feeling greasy. Users across all skin types—including those with sensitive, mature, or acne-prone skin—report improved skin texture, a plumper appearance, and a smooth, glowing finish that works exceptionally well under makeup.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Lightweight, non-greasy (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Makeup-friendly (sometimes noted)
- Liked: Sensitive skin safe (sometimes noted)
- Disliked: Insufficient for dry (rarely noted)
- Disliked: May feel heavy (rarely noted)
- Disliked: Unclear visible results (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes iS CLINICAL Reparative Moisture Emulsion a great fit for mature skin?

This moisturizer is a great fit for mature skin because it uses Tripeptide-10 Citrulline and Dipalmitoyl Hydroxyproline to help smooth out wrinkles and fine lines. Sodium Hyaluronate and Glycerin also give your skin plenty of moisture to keep it looking plump and soft.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### Which ingredients make this cream a good fit for mature skin?

Sodium Hyaluronate, Glycerin, Tripeptide-10 Citrulline, and Dipalmitoyl Hydroxyproline make this cream a great fit by targeting wrinkles and fine lines while deeply hydrating the skin. These ingredients help plump the skin, improve elasticity, and smooth out texture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes near the end of your routine, after your toner and before your sunscreen in the morning or as the final step in the evening. Using it daily helps smooth fine lines and keeps mature skin deeply hydrated and soft.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol to help smooth and hydrate mature skin, applying the retinol first and following with this moisturizer. Using a barrier-enhancing moisturizer like this one is unlikely to cause irritation and may help your skin tolerate the retinol better.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this moisturizing treatment twice a day as part of your morning and evening routine to keep your skin hydrated and smooth. Regular use helps soften fine lines and improves overall texture over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts for mature skin, as it features a safe formula with soothing ingredients and no harsh components. It helps keep skin smooth and hydrated without feeling heavy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use it around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, but because the skin around the eyes and on parts of the body is particularly thin, it helps to apply a gentle formula carefully to avoid irritation. This product is generally safe and unlikely to cause harsh reactions, making it suitable for delicate areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/mature-skin) — Superior fit — £14.74 at Amazon
- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/uk/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — £61.50 at Amazon
- [Kate Somerville K8 Peptide Intensive Cream](https://lovi.care/skincare/uk/p/kate-somerville/peptide-k8-power-cream/for/mature-skin) — Superior fit — £102.47 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/uk/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — £22.00 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Hyaluronate, Glycerin, Squalane, Caprylic Capric Triglyceride, Beta Vulgaris Root Extract, Haberlea Rhodopensis Leaf Extract, Yeast Extract, Tocopherol, Panthenyl Triacetate, Ethyl Linoleate, Butylene Glycol, Acetyl Tyrosine, Proline, Hydrolyzed Protein, Hydrolyzed Soy Protein, Tripeptide-10 Citrulline, Tripeptide-1, Lecithin, Xanthan Gum, Carbomer, Triethanolamine, Glycosaminoglycans, Urea, Glucose, Guanidine Hcl, Cetearyl Alcohol, Ceteareth-20, Dimethicone, Dipalmitoyl Hydroxyproline, Cyclomethicone, Polysorbate 40, Superoxide Dismutase, Pvp, Panthenol, Retinyl Palmitate, Tocopheryl Acetate, Ascorbyl Palmitate, Pantothenic Acid, Ethylbisiminomethylguaiacol Manganese Chloride, 1,2-Hexanediol, Caprylyl Glycol, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/reparative-moisture-emulsion/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
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- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/reparative-moisture-emulsion/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/reparative-moisture-emulsion/for/mature-skin