# iS Clinical Active Serum for dry sensitive skin

**Lovi Fit: Low fit for dry sensitive skin.**
Dry Skin Fit: Average · Effectiveness: High · Safety: Concerning.

Page: https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [iS Clinical](https://lovi.care/skincare/uk/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for dry sensitive skin; the serums alongside fit it better.

## Why this fit

- Offers moderate exfoliation for your dry or flaky skin due to Saccharum Officinarum Extract and Vaccinium Myrtillus Leaf Extract, but the concentration may not be sufficient for your current issues and poses a risk of worsening them.
- Glycerin offers humectant action for your dry skin, but the formula lacks sufficient emollient and occlusive ingredients to fully address dryness.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/dry-sensitive-skin): Low (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/oily-acne-prone-skin): High

## Key ingredients

Saccharum Officinarum Extract, Vaccinium Myrtillus Extract, Arbutin, Willow Bark Extract, Polyporus Umbellatus Extract Mushroom Extract

## What the research says

- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- A botanical face cleanser with hops and willow bark extract continuously reduced skin sebum levels without reactive seborrhea after treatment in 21 healthy volunteers compared to a sodium laureth sulfate cleanser, with neither cleanser causing skin irritation. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30022595/))
- Bioactive lipid nanocarriers co-loaded with willow bark or ivy leaf extracts and UV-filters provided pronounced UVA photoprotection up to an SPF-equivalent value of 13 and a maximum in vivo skin hydration effect of 97% when prepared with pomegranate oil. ([Nanomaterials, 2022](https://pubmed.ncbi.nlm.nih.gov/35889587/))
- A topical serum containing 0.5% salicin applied twice daily reduced visible signs of skin aging, including wrinkles and tactile roughness, in 30 female subjects over 12 weeks compared to baseline. ([Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883292/))
- White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury. ([Microscopy Research and Technique, 2012](https://pubmed.ncbi.nlm.nih.gov/22581761/))

## Why other serums fit dry sensitive skin better

- Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35274433/))
- In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle. ([Skin Pharmacology and Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/41758783/))
- Hydrogels containing vitamin E-loaded nanostructured lipid carriers exhibited better occlusive properties and long-lasting effects, while vitamin E-loaded nanoemulsions performed a faster skin hydration effect and were selected as more attractive for skin application. ([Colloids and Surfaces. B, Biointerfaces, 2019](https://pubmed.ncbi.nlm.nih.gov/30974262/))

## What reviewers say

Users consistently praise this serum as a "holy grail" multitasker that effectively targets adult acne while simultaneously smoothing fine lines and uneven texture. While the potent "tingling" sensation confirms its activity for most, the high price point and potential for dryness are common considerations for new users.

- Liked: Clears Acne & Breakouts (mostly mentioned)
- Liked: Improves Texture & Tone (often mentioned)
- Disliked: High Price Point (often mentioned)
- Liked: Anti-Aging Benefits (sometimes noted)
- Liked: Fast Visible Results (sometimes noted)
- Disliked: Intense Tingling Sensation (sometimes noted)
- Disliked: Drying for Some (rarely noted)
- Disliked: Risk of Counterfeits (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is iS Clinical Active Serum a weak match for dry sensitive skin?

iS Clinical Active Serum is a weak match because its exfoliating ingredients may not be enough for your dry skin and could worsen your issues, while its glycerin lacks enough rich, sealing ingredients to fully handle dryness. A treatment for dry sensitive skin needs soothing, highly hydrating ingredients that lock in moisture and nourish the skin barrier safely without causing irritation.

### Which ingredients make this serum a poor fit for dry sensitive skin?

Saccharum Officinarum Extract and Vaccinium Myrtillus Leaf Extract offer mild exfoliation, but they and Alcohol Denat may easily dry out or irritate sensitive skin. A treatment for this skin needs rich moisturizing and soothing ingredients that hydrate deeply and support the skin barrier without any risk of irritation.

### What does Sugarcane Extract do for dry sensitive skin?

Sugarcane Extract helps smooth dry skin while remaining gentle enough to keep sensitive areas calm and comfortable. It gently lifts away dead cells to reveal softer skin underneath without causing irritation.

### What does Bilberry Fruit Extract do for dry sensitive skin?

Bilberry Fruit Extract helps calm dry sensitive skin while making it feel soft and smooth. It works to improve skin firmness and hydration, and it is unlikely to cause irritation.
Sources: [Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/)

### Where does it go in a skincare routine for dry sensitive skin?

This treatment goes in the evening routine for dry sensitive skin, starting just once a week. Because this product is a weak match that may worsen dryness and irritation, a treatment for this skin needs rich softening ingredients like plant oils or butters to lock in moisture.

### Can I use this serum with retinol, and in what order?

Using this serum with retinol is unlikely to be a good fit for dry sensitive skin because it may easily cause irritation and worsen flaking. A product of this type needs rich smoothing and sealing ingredients to lock in moisture and calm sensitivity.

### How often should I use it?

You should use this treatment once a week in the evening since it is a weak match for your dry sensitive skin. A product of this type needs rich moisturizing ingredients and gentle soothing agents to properly comfort and protect dry skin.

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores, but it may cause purging or breakouts on dry sensitive skin because it contains Saccharum Officinarum Extract and Vaccinium Myrtillus Leaf Extract for exfoliation. A product of this type needs richer moisturizing and soothing ingredients to keep dry sensitive skin comfortable while it renews.

### Is it fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — £143.35 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — £36.96 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/uk/p/augustinus-bader/the-serum/for/dry-sensitive-skin) — Superior fit — £248.00 at Amazon

## Routine for dry sensitive skin

### AM

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/uk/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — £8.29 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/uk/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — £17.91 at Amazon
- Moisturizer with Sun Protection: [Real Barrier Mild Sun Cream](https://lovi.care/skincare/uk/p/real-barrier/mild-sun-cream/for/dry-sensitive-skin) — Superior fit — £19.01 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/uk/p/missha/ultra-hyalon-cleansing-cream/for/dry-sensitive-skin) — Superior fit — £13.58 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/uk/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — £8.29 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/uk/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — £17.91 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/uk/p/peach-and-lily/glass-skin-refining-serum/for/dry-sensitive-skin) — Superior fit — £59.74 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-sensitive-skin) — Superior fit — £38.50 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/uk/p/missha/ultra-hyalon-cleansing-cream/for/dry-sensitive-skin) — Superior fit — £13.58 at Amazon
- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/uk/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — £8.29 at Amazon
- Enzyme Powder: [Fancl Facial Washing Powder](https://lovi.care/skincare/uk/p/fancl/facial-washing-powder/for/dry-sensitive-skin) — Superior fit — £22.24 at Amazon
- Nourishing Mask: [MEDIHEAL Vita Essential Mask](https://lovi.care/skincare/uk/p/mediheal/vita-essential-mask/for/dry-sensitive-skin) — Superior fit — £17.00 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/uk/p/peach-and-lily/glass-skin-refining-serum/for/dry-sensitive-skin) — Superior fit — £59.74 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-sensitive-skin) — Superior fit — £38.50 at Amazon

## Where to buy

- Amazon.co.uk: £87.00 (https://www.amazon.co.uk/dp/B0073RK3S2?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Alcohol Denat, Saccharum Officinarum Extract, Vaccinium Myrtillus Leaf Extract Fruit, Triethanolamine, Willow Bark Extract, Glyceryl Polyacrylate, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Menthol, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/active-serum/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/active-serum/for/dry-sensitive-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/active-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/active-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/active-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/active-serum/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/active-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/active-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/active-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/active-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/active-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/active-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/active-serum/for/dry-sensitive-skin