# IOPE Pro Peeling Enzyme Wash for dry sensitive skin

**Lovi Fit: Average fit for dry sensitive skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [IOPE](https://lovi.care/skincare/uk/brands/iope)
Category: [Exfoliants](https://lovi.care/skincare/uk/best/exfoliators)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry sensitive skin; other products fit it better.

## Why this fit

- Offers moderate exfoliation for your dry and sensitive skin, as papain and protease help smooth texture, while allantoin and squalane provide soothing and supportive benefits.
- The formula includes lemon fruit extract and saccharum officinarum extract to offer general skincare benefits like hydration and soothing for your dry or flaky skin.
- The product is safe for your dry and sensitive skin, as it contains no harsh ingredients and includes soothing components like allantoin and squalane.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin): Average (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin): High

## Key ingredients

Papain, Squalane, Acetyl Glucosamine, Betaine, Vaccinium Myrtillus Fruit Extract

## What the research says

- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate. ([Scientific Reports, 2020](https://pubmed.ncbi.nlm.nih.gov/33037252/))
- Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities. ([Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))

## What reviewers say

Based on limited data, users find this enzyme wash effectively exfoliates and smooths skin, leaving it feeling soft and clean without dryness, making it suitable for sensitive skin. However, the product is considered expensive for the quantity provided, and the powder format can lead to clumping and dispensing difficulties.

- Liked: Improved skin texture (mostly mentioned)
- Liked: Gentle exfoliation (often mentioned)
- Liked: Non-stripping cleanse (often mentioned)
- Disliked: Expensive for amount (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Effective deep clean (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your enzyme powder cleanser PM once a week as part of your weekly routine, and start slowly to check your skin's tolerance.
- Place this step right after your regular cleanser and before your hydrating toner, following the weekly routine order.
- Mix the powder with a little water in your hands to create a soft foam, then gently massage it onto your face without rubbing hard.
- Apply the foam on slightly damp skin to keep your dry flakes comfortable and safe from extra irritation.
- Be sure to avoid the delicate eye area and do a patch test before your very first use.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### How well does IOPE Pro Peeling Enzyme Wash work for dry sensitive skin?

IOPE Pro Peeling Enzyme Wash works moderately well for dry sensitive skin by offering gentle exfoliation and soothing support from ingredients like squalane and allantoin. A product of this type needs richer hydrating ingredients and a stronger moisture barrier support to be a top fit for this skin type.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/), [Scientific Reports, 2020](https://pubmed.ncbi.nlm.nih.gov/33037252/)

### Which ingredients make this cleanser a good fit for dry sensitive skin?

Papain and protease smooth texture while squalane and allantoin help soothe and support dry sensitive skin. A product for this skin needs effective hydrating ingredients and gentle exfoliators that cleanse without causing irritation or compromising moisture levels.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/), [Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/)

### What does Papain do for dry sensitive skin?

Papain is generally too harsh for dry, sensitive skin because it breaks down skin proteins and may cause irritation and barrier disruption. Instead, dry and sensitive skin needs gentle, hydrating ingredients like glycerin or soothing plant extracts to keep the skin calm and smooth.
Sources: [The Journal of Investigative Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25705851/)

### What does Squalane do for dry sensitive skin?

Squalane helps keep dry sensitive skin soft and smooth by locking in moisture and calming irritation without causing flare-ups. It is unlikely to cause redness or discomfort, making it a gentle choice that supports the skin barrier. This type of skin needs ingredients that deeply hydrate and soothe, such as plant oils and antioxidants.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/), [Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/)

### Where does this cleanser go in a skincare routine for dry sensitive skin?

This cleanser fits into your morning and evening routine as a face wash, while enzyme powders like this one are best started just once a week for dry sensitive skin. A product of this type needs gentle exfoliating enzymes alongside soothing, hydrating ingredients like squalane and allantoin to keep flaky skin smooth without feeling dry.

### Can I use this cleanser with retinol, and in what order?

You can use this cleanser in your evening routine, but use it on nights when you are not applying retinol to avoid drying out your skin. To better fit dry and sensitive skin, a cleanser of this type needs gentle, hydrating ingredients and rich moisturizing components that protect the skin barrier.

### How often should I use this cleanser?

Start by using this enzyme powder cleanser just once a week to see how your dry sensitive skin handles it, and if it feels comfortable and stays calm, you may carefully use it more often. To work best for this skin type, a cleanser of this type needs gentle exfoliating enzymes alongside soothing ingredients like allantoin and squalane.

### Can this cleanser clog pores, cause breakouts or purging for dry sensitive skin?

This cleanser is unlikely to cause breakouts or clogging for dry sensitive skin since it contains no harsh ingredients and includes soothing components like allantoin and squalane. It provides moderate exfoliation with papain and protease to help smooth texture while supporting skin comfort.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/), [Scientific Reports, 2020](https://pubmed.ncbi.nlm.nih.gov/33037252/)

### Is this cleanser fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (ethanol).

## Alternatives for dry sensitive skin

- [VT Cica Mild Powder Wash](https://lovi.care/skincare/uk/p/vt/cica-mild-powder-wash/for/dry-sensitive-skin) — High fit — £9.55 at Amazon
- [Dr. Barbara Sturm Enzyme Cleanser](https://lovi.care/skincare/uk/p/dr-barbara-sturm/enzyme-cleanser/for/dry-sensitive-skin) — Average fit — £55.00 at Lookfantastic

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/uk/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — £8.29 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/uk/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — £17.91 at Amazon
- Moisturizer with Sun Protection: [Real Barrier Mild Sun Cream](https://lovi.care/skincare/uk/p/real-barrier/mild-sun-cream/for/dry-sensitive-skin) — Superior fit — £19.01 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Microcrystalline Cellulose, Sodium Cocoyl Glycinate, Sodium Lauroyl Glutamate, Silica, Papain, Protease, Lipase, Lemon Fruit Extract, Saccharum Officinarum Extract, Sugar Maple Extract, Vaccinium Myrtillus Fruit Extract, Citrus Aurantium Dulcis Fruit Extract, Betaine, Squalane, Acetyl Glucosamine, Allantoin, Chitosan, Alpha-Glucan Oligosaccharide, Ethyl Cellulose, Ethanol, Xanthan Gum, Water, Butylene Glycol, Polycaprolactone, Peg-75, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin