Eighth Day Regenerative Serum for oily skin
Peptide-Rich Plasma
Sodium Hyaluronate
Niacinamide
Acetyl Glutamine
Manuka Honey
Average
- HighOily Skin Fit
- AverageEffectiveness
- Low RiskSafety
Works for oily skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate exfoliation and seboregulation for your oily skin, with niacinamide and glycolic acid helping to refine texture and control shine.
- The serum provides excellent skin regeneration through multiple peptides that smooth fine lines, though it lacks specific ingredients to directly address your primary concern of oily shine.
- The product is generally safe for your skin, with a low risk of irritation from glycolic acid.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
People Say
★4.5Overall rating based on 300+ reviewsThis serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.
Highlights
High price Mostly Mentioned
- “hefty price tag”
- “hard to justify”
- “investment skincare”
- “wallet-draining”
Fast absorption Often Mentioned
- “Lightweight, non-sticky, sinks in immediately, satin finish, layers well”
Visible anti-aging Often Mentioned
- “Smoother fine lines, plumper skin, increased firmness, brighter complexion, "instant glow."”
High-tech ingredients Sometimes Noted
- “Peptide-Rich Plasma, bio-identical actives, stem cell technology, clean formula, fragrance-free”
Hydration Sometimes Noted
- “Deeply hydrating, restores moisture barrier, skin feels bouncy, eliminates dryness”
Lack of results Sometimes Noted
- “No visible difference”
- “didn't work for me”
- “overhyped”
- “saw no change”
- “cheaper alternatives work better”
Packaging Rarely Noted
- “Sleek black bottle, airless pump, luxurious design, dispenses perfect amount”
Availability issues Rarely Noted
- “Frequently sold out”
- “hard to find”
- “waitlists”
- “stock issues”
No acne benefit Rarely Noted
- “Did not help breakouts”
- “didn't reduce acne”
- “neutral on blemishes”
Texture complaints Rarely Noted
- “Slightly tacky for some”
- “hard to spread (rare)”
- “leaves a film”
- “requires quick application”
Sources: lovi.care, nordstrom.com, violetgrey.com, editorialist.com, whowhatwear.com, reddit.com, and more
Questions and answers
How well does Eighth Day Regenerative Serum work for oily skin?
Eighth Day Eighth Day Regenerative Serum is an average fit for oily skin because while it controls shine with niacinamide, it lacks specific ingredients to directly target excess oil. To work better for oily skin, a product of this type needs ingredients like zinc PCA and ferulic acid to manage shine and enlarged pores, along with ceramides and panthenol to keep the skin balanced without clogging pores.
Scientific Reports, 2024Journal of Cosmetic Dermatology, 2021
Which ingredients make this serum a good fit for oily skin?
Niacinamide, glycolic acid, and sodium hyaluronate make this serum a good fit by helping to control shine and smooth your skin. To better manage oily skin, products of this type need targeted sebum-controlling ingredients like zinc PCA or ferulic acid alongside soothing extracts and non-clogging hydrators.
What does Peptide-Rich Plasma do for oily skin?
Peptide-Rich Plasma helps improve skin firmness and supports overall skin rejuvenation. This treatment is unlikely to cause severe adverse effects while helping smooth and strengthen aging or tired skin.
What does Hyaluronic Acid do for oily skin?
Hyaluronic acid helps oily skin by reducing extra oil and sebum production without causing irritation. Clinical studies show it successfully balances oil levels while keeping the skin comfortable.
Where does this serum go in a skincare routine for oily skin?
This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Oily skin of this type needs products containing oil-absorbing powders and deep-cleansing clay to help control excess shine.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying it after your retinol treatment, or on alternate nights to avoid overwhelming your skin. This product works for your oily skin, though it lacks specific ingredients to directly address oily shine; an oily skin routine needs ingredients like niacinamide and salicylic acid to control oil and refine texture.
How often should I use this serum?
This serum works for your oily skin in the evening routine, starting at once a week and slowly building up if your skin tolerates it well. It offers moderate shine control and smoothing with niacinamide and glycolic acid, though an oily skin type also needs targeted oil-absorbing or mattifying ingredients to fully manage excess shine.
Can this serum clog pores, cause breakouts or purging for oily skin?
This serum is unlikely to cause breakouts or clog pores on oily skin, and the low amount of glycolic acid may bring a very mild chance of irritation. Oily skin works best with a treatment that includes oil-absorbing ingredients and lightweight hydrators to properly control shine.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients.
Archives of Dermatological Research, 2025Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars.
Journal of Cutaneous and Aesthetic Surgery, 2024Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious.
Journal of Drugs in Dermatology, 2020Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.
Journal of Cosmetic and Laser Therapy, 2006Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes.
The Ocular Surface, 2020Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks.
The British Journal of Ophthalmology, 2022The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing.
Medical Science Monitor, 2010
Why other serums fit oily skin better
A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022
Ingredients
Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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