# Eighth Day Regenerative Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Eighth Day](https://lovi.care/skincare/uk/brands/eighth-day)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- This serum offers excellent skin treatment for your combination skin, as multiple peptides like Sh-Oligopeptide-2 and Palmitoyl Tripeptide-5 support skin restoration and firmness, while niacinamide aids in barrier repair.
- Glycerin and Sodium Hyaluronate provide essential hydration to manage oily shine, though the inclusion of Glycolic Acid presents a moderate risk of irritation for your skin.
- The product is generally safe for your skin, with a low potential for adverse reactions.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Peptide-Rich Plasma, Sodium Hyaluronate, Niacinamide, Acetyl Glutamine, Manuka Honey

## What the research says

- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients. ([Archives of Dermatological Research, 2025](https://pubmed.ncbi.nlm.nih.gov/40167803/))
- Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars. ([Journal of Cutaneous and Aesthetic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/38800810/))
- Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346518/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes. ([The Ocular Surface, 2020](https://pubmed.ncbi.nlm.nih.gov/31759183/))
- Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks. ([The British Journal of Ophthalmology, 2022](https://pubmed.ncbi.nlm.nih.gov/33419788/))
- The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing. ([Medical Science Monitor, 2010](https://pubmed.ncbi.nlm.nih.gov/20980964/))

## What reviewers say

This serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.

- Disliked: High price (mostly mentioned)
- Liked: Fast absorption (often mentioned)
- Liked: Visible anti-aging (often mentioned)
- Liked: High-tech ingredients (sometimes noted)
- Liked: Hydration (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Liked: Packaging (rarely noted)
- Disliked: Availability issues (rarely noted)
- Disliked: No acne benefit (rarely noted)
- Disliked: Texture complaints (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Eighth Day Regenerative Serum work for combination skin?

This serum works well for combination skin, as multiple peptides and niacinamide support firmness and help repair the skin barrier while sodium hyaluronate and glycerin provide hydration to manage oily shine. However, it is an average fit because the inclusion of glycolic acid presents a moderate risk of irritation. A product of this type needs effective ingredients like niacinamide, propolis, and zinc PCA that regulate oiliness, enhance radiance, and provide adequate hydration without any risk of irritation or unsuitability.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### Which ingredients make this serum a good fit for combination skin?

This serum works well for combination skin because it contains peptides like palmitoyl tripeptide-5 that support firmness, alongside niacinamide, glycerin, and sodium hyaluronate which provide essential hydration and help manage oily shine. To be a better fit for this skin type, a product like this needs ingredients such as niacinamide, propolis, or zinc PCA that regulate oiliness and boost radiance without any risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### What does Peptide-Rich Plasma do for combination skin?

Platelet-rich plasma helps improve skin elasticity and overall facial appearance when used for combination skin. To work best for this skin type, a product of this type needs nourishing growth factors and hydrating ingredients that balance oily and dry areas without clogging pores.
Sources: [Aesthetic Surgery Journal, 2021](https://pubmed.ncbi.nlm.nih.gov/33534905/), [Dermatologic Surgery, 2012](https://pubmed.ncbi.nlm.nih.gov/22288389/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does it go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and before moisturizing. Combination skin needs products with balancing hydrators like sodium hyaluronate and soothing ingredients like niacinamide to manage oily shine while supporting the skin barrier.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first at night and following with this serum, though the glycolic acid it contains may occasionally irritate your skin. Combination skin needs products that balance oil and hydration with soothing ingredients while keeping the risk of irritation low.

### How often should I use it?

Use this serum in your evening routine once a week to start, and you may slowly use it more often if your skin tolerates it well. To work best for your combination skin, a product of this type needs soothing ingredients and gentle hydrators to manage oily shine while keeping the skin calm and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin, as it has a very low potential for adverse reactions. However, because it contains glycolic acid, it may occasionally cause mild irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/uk/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — £36.96 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — £24.20 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/uk/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — £248.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — £30.37 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/uk/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — £14.80 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/combination-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/eighth-day/regenerative-serum/for/combination-skin
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