# Drunk Elephant Protini Polypeptide Cream for sensitive skin

**Lovi Fit: Superior fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Drunk Elephant](https://lovi.care/skincare/uk/brands/drunk-elephant)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for sensitive skin.

## Why this fit

- Excellent for your normal, sensitive skin as peptides like Sh-Oligopeptide-1 and Sh-Oligopeptide-2 support collagen stimulation and extracellular matrix synthesis, while humectants like Glycerin and Sodium Hyaluronate provide essential hydration.
- The inclusion of Nymphaea Alba Root Extract and Tocopherol offers soothing benefits, further enhancing barrier function and reducing redness for your skin concerns.
- This formula is exceptionally safe, free from harsh ingredients and containing soothing components that minimize irritation risk for sensitive skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/combination-skin): Superior
- [Sensitive skin](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin): Superior (this page)
- [Acne-prone skin](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin): High

## Key ingredients

9 Signal Peptides, Pygmy Waterlily, Sodium Hyaluronate, Glycerin, Copper Palmitoyl Heptapeptide-14

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Water lily rhizome extract protected human epidermal keratinocytes against UVB-induced mitochondria-mediated apoptosis by reducing reactive oxygen species generation, mitochondrial dysfunction, and apoptotic signaling while increasing antiapoptotic proteins and antioxidant levels. ([Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this moisturizer is frequently praised for its lightweight, non-greasy texture that firms and plumps the skin, making it a favorite for combination and oily skin types. It also performs well under makeup and is generally well-tolerated by sensitive skin. However, some users with very dry skin find it lacks sufficient hydration, and a significant number of reviews mention the high price point as a drawback.

- Liked: Lightweight texture (mostly mentioned)
- Disliked: High price (mostly mentioned)
- Liked: Hygienic packaging (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Sensitive skin friendly (sometimes noted)
- Liked: Visible results (sometimes noted)
- Disliked: Dry skin hydration (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Drunk Elephant Protini Polypeptide one of the best fits for sensitive skin?

Drunk Elephant Protini Polypeptide Cream is one of the best fits for sensitive skin because its peptides support collagen while humectants like glycerin and sodium hyaluronate provide essential hydration. Plant extracts and vitamin E help calm redness and protect your skin barrier with a very low risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for sensitive skin?

This cream is a great fit for sensitive skin because it contains glycerin and sodium hyaluronate to provide essential hydration, alongside peptides that support collagen. It also includes soothing ingredients like waterlily extract and vitamin E, which help calm redness and keep the skin barrier strong with a low risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Signal Peptides do for sensitive skin?

Signal peptides help sensitive skin by signaling skin cells to build supportive proteins like collagen that keep skin firm and resilient. Because sensitive skin varies widely, this type of product needs gentle, soothing ingredients and barrier-repairing components to avoid irritation.
Sources: [Current Protein & Peptide Science, 2021](https://pubmed.ncbi.nlm.nih.gov/34382523/)

### What does Pygmy Waterlily do for sensitive skin?

Pygmy Waterlily helps calm sensitive skin by protecting cells against sun-induced stress and reducing damage from free radicals. It helps shield the skin's surface and supports a more comfortable feel.
Sources: [Pharmacology, 2016](https://pubmed.ncbi.nlm.nih.gov/26915077/)

### Where does this cream go in a skincare routine for sensitive skin?

This cream goes in your evening routine as a moisturizing treatment step after your cleanser, soothing toner, and any targeted serums. Using a gentle moisturizer helps lock in hydration and supports your skin barrier without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, and applying it after your retinol may help calm your skin and reduce redness. Using a gentle moisturizer alongside retinoids is well tolerated and supports your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this cream?

This cream is exceptionally safe and suitable for sensitive skin, making it gentle enough for daily use as part of your evening routine. Regular application helps provide essential hydration, supports skin barrier function, and minimizes the risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This moisturizing treatment is unlikely to cause breakouts for sensitive skin, as negative reviews regarding clogged pores or breakouts are very low. The formula features soothing components and avoids harsh ingredients that typically trigger irritation.

### Can I use this cream around the eyes or on my body?

Yes, you can use this moisturizing treatment on your body and around the eyes because its gentle formula is exceptionally safe for sensitive skin. It helps calm and hydrate delicate areas while minimizing the risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/uk/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — £14.74 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/uk/p/cosrx/advanced-snail-96-mucin-power-essence/for/sensitive-skin) — Superior fit — £12.21 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/uk/p/belif/the-true-cream-aqua-bomb/for/sensitive-skin) — High fit — £32.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — £14.99 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/uk/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — £17.91 at Amazon
- Moisturizer with Sun Protection: [Clinique Mineral Sunscreen Fluid for Face SPF 50](https://lovi.care/skincare/uk/p/clinique/broad-spectrum-spf-50-mineral-sunscreen-fluid-for-face/for/sensitive-skin) — Superior fit — £21.00 at Amazon

## Where to buy

- Lookfantastic: £62.00 (https://www.lookfantastic.com/p/drunk-elephant-protini-polypeptide-face-moisturiser-50ml/13344888/)
Prices checked 17 Oct 2026.

## Ingredients

Water, Dicaprylyl Carbonate, Glycerin, Cetearyl Alcohol, Cetearyl Olivate, Sorbitan Olivate, Sclerocarya Birrea Seed Oil, Bacillus Folic Acid Extract Ferment, Nymphaea Alba Root Extract, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Alanine, Arginine, Glycine, Histidine, Isoleucine, Phenylalanine, Proline, Serine, Threonine, Valine, Acetyl Glutamine, Coconut Alkanes, Coco-Caprylate Caprate, Sodium Hyaluronate, Aspartic Acid, Linoleic Acid, Linolenic Acid, Lecithin, Butylene Glycol, Polyvinyl Alcohol, Sodium Lactate, Sodium Pca, Pca, Sorbitan Isostearate, Carbomer, Polysorbate 20, Polysorbate 60, Lactic Acid Glycolic Acid Copolymer, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Xanthan Gum, Isomalt, 1,2-Hexanediol, Caprylyl Glycol, Chlorphenesin, Phenoxyethanol, Tocopherol, Sodium Benzoate, Phenylpropanol, Glyceryl Caprylate, Symphytum Officinale Callus Culture Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/drunk-elephant/protini-polypeptide-cream/for/sensitive-skin
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