# Dr. Lili Fan Probiotic Age Defying Eye Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Dr. Lili Fan](https://lovi.care/skincare/uk/brands/dr-lili-fan)
Category: [Eye care and eye patches](https://lovi.care/skincare/uk/best/eye-creams)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few eye cares fit it even better.

## Why this fit

- Highly suitable for normal skin, this serum effectively addresses wrinkles and fine lines with Myristoyl Pentapeptide-17 and Palmitoyl Oligopeptide, which support collagen production and skin elasticity.
- Sodium Hyaluronate and Glycerin provide excellent humectant action, while Lactobacillus Ulkenia Extract Ferment Filtrate and Bifida Lysate Ferment enhance barrier repair for overall skin health.
- The product is safe for your skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Myristoyl Pentapeptide-17, Palmitoyl Tetrapeptide-7, Lactobacillus Ulkenia Extract Ferment Filtrate, Bifida Lysate Ferment

## What the research says

- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## Questions and answers

### What makes Dr. Lili Fan Probiotic Eye Serum a great fit for mature skin?

This eye serum is a great fit for mature skin because it uses peptides like Myristoyl Pentapeptide-17 and Palmitoyl Oligopeptide to support collagen production and improve elasticity. Sodium hyaluronate and glycerin draw in moisture, while probiotic ferments help repair the skin barrier. It is also safe and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because ingredients like Myristoyl Pentapeptide-17 and Palmitoyl Tetrapeptide-7 help support collagen production and firmness. Sodium Hyaluronate and Glycerin boost hydration, while Lactobacillus Ulkenia Extract Ferment Filtrate and Bifida Lysate Ferment strengthen the skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Myristoyl Pentapeptide-17 do for mature skin?

Myristoyl Pentapeptide-17 helps smooth wrinkles and keeps mature skin firm and hydrated. Peptide complexes like this stimulate proteins in the skin to improve elasticity and reduce the depth of lines.
Sources: [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335808/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine as a treatment step, applied after cleansing and before moisturizing. Using it at night offers simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to keep your skin hydrated and smooth while retinization takes place. This approach helps maintain your skin barrier and is unlikely to cause irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

This serum fits well into an evening routine, which is best for treatments with active ingredients for simplicity and extra safety around sun exposure. Some serums may also be used in the morning or twice a day if your skin tolerates them well.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is a great fit for mature skin and is unlikely to clog pores or cause breakouts because it contains no harsh or heavy ingredients. Its lightweight blend absorbs easily while supporting firmness and hydration without weighing skin down.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Elizabeth Arden Prevage Anti-Aging Eye Serum](https://lovi.care/skincare/uk/p/elizabeth-arden/prevage-anti-aging-eye-serum-2-0/for/mature-skin) — High fit — £88.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — £38.50 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Water, Sodium Hyaluronate, Menthyl Lactate, Asiatic Acid, Pentylene Glycol, Panthenol, Steareth-20, Glycerin, Lysolecithin, N-Hydroxysuccinimide, Hydroxyethylcellulose, Chrysin, Myristoyl Pentapeptide-17, Cocoyl-Oligopeptide, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Rice Protein, Lactobacillus Ulkenia Extract Ferment Filtrate, Bifida Lysate Ferment, Phenoxyethanol, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/dr-lili-fan/probiotic-age-defying-eye-serum/for/mature-skin