Dear, Klairs Freshly Juiced Vitamin Drop for oily acne-prone skin

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Questions and answers

What the research says

• Topical combination of 5% sodium ascorbyl phosphate and 0.2% retinol reduced inflammatory acne lesions by 29.28% at 4 weeks and 63.10% at 8 weeks, outperforming either agent alone.

  International Journal of Cosmetic Science, 2009

• Combined ascorbyl palmitate and sodium ascorbyl phosphate treatment significantly reduced facial sebum secretions in healthy female volunteers compared to a placebo control over 90 days.

  Drug Research, 2017

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Topical application of an aqueous gel containing 0.1% w/w naringenin demonstrated in vitro safety, significantly reduced UV-induced stratum corneum lipid peroxidation, and showed in vivo anti-inflammatory efficacy against methyl nicotinate-induced inflammation in human participants compared to a blank gel and untreated area, while chlorogenic acid, apigenin, and kaempferol displayed pro-oxidant profiles.

  Frontiers in Chemistry, 2024

• Topical application of a naringenin-containing formulation protected hairless mice from ultraviolet B-induced skin damage by inhibiting edema, cytokine production, superoxide anion, and lipid hydroperoxides while maintaining antioxidant enzymes and glutathione levels.

  PloS One, 2016

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Encapsulating naringenin, nordihydroguaiaretic acid (NDGA), and kaempferol into nanostructured lipid carriers provided prolonged release, stability, and antioxidant protection against oxidative stress in human keratinocytes, with an NDGA and kaempferol mixture showing synergistic antioxidant effects.

  Pharmaceutics, 2021

• Naringenin prevented UV-B radiation-induced mitochondrial fragmentation, oxidative stress, and inflammation in human dermal fibroblasts and Balb/c mice.

  Journal of Photochemistry and Photobiology. B, Biology, 2024

• Mangiferin increased the photostability and reduced the phototoxic potential of sunscreens containing avobenzone and naringenin tested on 3T3 fibroblast cultures and cosmetic formulations.

  Journal of Photochemistry and Photobiology. B, Biology, 2015

• Citrus junos callus extract decreased melanin content in melanocytes 1.85-fold compared with arbutin and promoted the proliferation of and procollagen synthesis by human fibroblasts by 154% and 176% at 500 μg/mL.

  Molecules, 2017

• Yuja-peel fractions (ethyl acetate, hexane, and butanol) inhibited MMP expression, induced moisturizing factors filaggrin and serine palmitoyltransferase, and decreased melanin content in UVB-irradiated HaCaT, HDF, and α-MSH-treated B16F10 cells.

  Antioxidants, 2022

• Upcycled low-molecular-weight anionic peptides from Citrus junos seeds protected UVR-irradiated keratinocytes and reconstructed skin tissue by scavenging reactive oxygen species, reducing paracrine cytokines, inhibiting melanin synthesis and TRP-2 expression, and increasing filaggrin, laminin-5, and type I collagen expression.

  International Journal of Molecular Sciences, 2024

Ingredients

Water, Propylene Glycol, Ascorbic Acid, Hydroxyethylcellulose, Centella Asiatica Extract, Citrus Junos Fruit Extract, Illicium Verum Fruit Extract Anise Fruit Extract, Grapefruit Fruit Extract, Nelumbo Nucifera Flower Extract, Paeonia Suffruticosa Root Extract, Scutellaria Baicalensis Root Extract, Polysorbate 60, Brassica Oleracea Italica Extract, Chaenomeles Sinensis Fruit Extract, Citrus Aurantium Dulcis Oil, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Disodium Edta, Lavandula Angustifolia Oil Lavender Oil, Camellia Sinensis Callus Culture Extract, Larix Europaea Extract Wood, Chrysanthellum Indicum Extract, Rheum Palmatum Root Extract, Asarum Sieboldi Root Extract, Quercus Mongolia Leaf Extract, Persicaria Hydropiper Extract, Corydalis Turtschaninovii Root Extract, Coptis Chinensis Root Extract, Magnolia Obovata Bark Extract, Lysine Hcl, Proline, Sodium Ascorbyl Phosphate, Acetyl Methionine, Theanine, Lecithin, Acetyl Glutamine, Sh-Oligopeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Bacillus Soybean Folic Acid Extract Ferment, Sodium Hyaluronate, Caprylyl Glycol, Butylene Glycol, 1,2-Hexanediol, Limonene

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.