# Cetaphil Ceramide Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Cetaphil](https://lovi.care/skincare/uk/brands/cetaphil)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent suitability for your normal skin is provided by ceramides, hyaluronic acid, and panthenol, which support barrier repair, hydration, and anti-inflammatory action, offering moderate benefits for your wrinkles and fine lines.
- The formulation's inclusion of cholesterol and additional ceramides (NP, AP, EOP) further enhances barrier resilience and hydration, complementing the primary humectant and barrier-supporting ingredients.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like allantoin and panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/oily-acne-prone-skin): High

## Key ingredients

Ceramides, Hyaluronic Acid, Glycerin, Phytosphingosine, Cholesterol

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Application of Body Lotion for 5 weeks on cosmetic dry skin improved barrier properties, increased levels of cholesterol, ceramides, and long-chain fatty acids, increased beneficial skin bacteria, and enhanced microbiome functional potential compared to baseline. ([Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of an emulsion containing a complete mixture of ceramides III, IIIB, VI, phytosphingosine, cholesterol, and linoleic acid significantly accelerated barrier recovery after SLS damage and improved skin hydration after acetone treatment in human volunteers compared to an emulsion containing only two types of ceramides. ([Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/))
- Phytosphingosine demonstrates anti-microbial and anti-inflammatory activity with excellent clinical results in acne vulgaris. ([International Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/18489348/))
- Phytosphingosine increased filaggrin metabolism and skin hydration in human skin by stimulating filaggrin biosynthesis and degradation leading to natural moisturizing factor formation. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28936777/))
- Botulinum toxin-A encapsulated in phosphatidylcholine/cholesterol nanoliposomes delivered transdermally achieved a diffusion depth of 380 μm and showed a nonsignificant advantage in relieving post-acne scarring compared to hyaluronic acid hydrogel treatment in 12 facial patients. ([Journal of Materials Science. Materials in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/39073502/))
- Topical application of cholesterol sulfate increases stratum corneum thickness and inhibits protease-induced cell dissociation by competitively inhibiting serine proteases in mice and human stratum corneum. ([The Journal of Investigative Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9699715/))
- Topical lovastatin treatment impairs the recovery of cutaneous permeability barrier function and stratum corneum cholesterol levels after acetone disruption in mice, an effect normalized by simultaneous treatment with mevalonate or cholesterol. ([The Journal of Clinical Investigation, 1990](https://pubmed.ncbi.nlm.nih.gov/2243142/))

## What reviewers say

Users with dry, sensitive, and combination skin praise this serum for its ability to repair the moisture barrier and calm redness without causing irritation. The lightweight, fragrance-free formula is frequently noted for improving skin texture and providing long-lasting hydration, though some users with oily skin find it leaves a slight tackiness.

- Liked: Lightweight & non-greasy (mostly mentioned)
- Liked: Effective hydration (often mentioned)
- Liked: Soothing & gentle (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Price vs. size (sometimes noted)
- Disliked: Insufficient for very dry (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Cetaphil Ceramide Serum a great fit for mature skin?

Cetaphil Ceramide Serum is a great fit for mature skin because ceramides, hyaluronic acid, and panthenol help repair the skin barrier, boost hydration, and calm irritation while moderately helping with wrinkles and fine lines. Cholesterol and extra ceramides further strengthen the skin barrier and moisture levels, and the formula is very unlikely to cause irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

Ceramides, hyaluronic acid, glycerin, and cholesterol make this serum a great fit because they help restore the skin barrier, boost hydration, and smooth out fine lines. Panthenol and allantoin add a soothing touch that keeps your skin calm and comfortable without irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What do Ceramides do for mature skin?

Ceramides help keep mature skin hydrated and smooth by repairing the outer moisture barrier and supporting water retention. This type of ingredient helps improve skin texture and elasticity while reducing dryness, which makes it particularly useful for aging skin that tends to lose moisture easily.
Sources: [Dermatologic Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/31585489/), [International Journal of Immunopathology and Pharmacology, 2008](https://pubmed.ncbi.nlm.nih.gov/18336739/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, following the routine for mature skin. Using it at this time keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to help calm and hydrate your skin before using retinol. This routine helps keep your skin comfortable and supports its barrier while you use retinoids.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine. Daily application helps improve skin moisture, smoothness, and fine lines while keeping your skin calm.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores because it lacks harsh ingredients and includes soothing components like allantoin and panthenol. Its gentle formulation makes it very safe for daily use on mature skin.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum around the eyes and on the body because its gentle blend features soothing ingredients that are safe for thin areas and provide excellent suitability without irritation. Regular application helps keep mature skin hydrated and smooth while improving fine lines.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/uk/p/revision-skincare/hydrating-serum/for/mature-skin) — High fit — £133.23 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/uk/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/mature-skin) — High fit — £25.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- SPF: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/uk/p/torriden/dive-in-mild-sunscreen/for/mature-skin) — Superior fit — £22.00 at Amazon

## Where to buy

- Amazon.co.uk: £24.99 (https://www.amazon.co.uk/dp/B0CZD72G5W?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Cetearyl Alcohol, Ceteareth-20, Ceramide Np, Ceramide Ap, Ceramide Eop, Phytosphingosine, Cholesterol, Hyaluronic Acid, Tocopheryl Acetate, Panthenol, Allantoin, Xanthan Gum, Carbomer, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/cetaphil/ceramide-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/cetaphil/ceramide-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/cetaphil/ceramide-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/cetaphil/ceramide-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/cetaphil/ceramide-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/cetaphil/ceramide-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/cetaphil/ceramide-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/cetaphil/ceramide-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/cetaphil/ceramide-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/cetaphil/ceramide-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/cetaphil/ceramide-serum/for/mature-skin