# Cetaphil Ceramide Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [Cetaphil](https://lovi.care/skincare/uk/brands/cetaphil)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/uk/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for combination skin.

## Why this fit

- Excellent suitability for your combination skin as ceramides, hyaluronic acid, and panthenol work synergistically to repair your skin barrier, provide essential hydration, and reduce inflammation, effectively addressing oily shine.
- Allantoin and tocopheryl acetate further support skin soothing and antioxidant protection, complementing the primary ingredients for overall skin health.
- The formula is safe for your skin, containing no harsh or prohibited ingredients and featuring a blend of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/oily-acne-prone-skin): High

## Key ingredients

Ceramides, Hyaluronic Acid, Glycerin, Phytosphingosine, Cholesterol

## What the research says

- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel. ([Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/))
- Phytosphingosine demonstrates anti-microbial and anti-inflammatory activity with excellent clinical results in acne vulgaris. ([International Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/18489348/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of an emulsion containing a complete mixture of ceramides III, IIIB, VI, phytosphingosine, cholesterol, and linoleic acid significantly accelerated barrier recovery after SLS damage and improved skin hydration after acetone treatment in human volunteers compared to an emulsion containing only two types of ceramides. ([Journal of the European Academy of Dermatology and Venereology, 2002](https://pubmed.ncbi.nlm.nih.gov/12482041/))
- Phytosphingosine increased filaggrin metabolism and skin hydration in human skin by stimulating filaggrin biosynthesis and degradation leading to natural moisturizing factor formation. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28936777/))
- Phytosphingosine inhibits melanin synthesis in cultured melan-a cells and a reconstructed human skin model by modulating MITF through suppression of gene expression and induction of protein degradation. ([Journal of Dermatological Science, 2017](https://pubmed.ncbi.nlm.nih.gov/28390782/))
- Botulinum toxin-A encapsulated in phosphatidylcholine/cholesterol nanoliposomes delivered transdermally achieved a diffusion depth of 380 μm and showed a nonsignificant advantage in relieving post-acne scarring compared to hyaluronic acid hydrogel treatment in 12 facial patients. ([Journal of Materials Science. Materials in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/39073502/))
- Topical application of cholesterol sulfate increases stratum corneum thickness and inhibits protease-induced cell dissociation by competitively inhibiting serine proteases in mice and human stratum corneum. ([The Journal of Investigative Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9699715/))
- Topical lovastatin treatment impairs the recovery of cutaneous permeability barrier function and stratum corneum cholesterol levels after acetone disruption in mice, an effect normalized by simultaneous treatment with mevalonate or cholesterol. ([The Journal of Clinical Investigation, 1990](https://pubmed.ncbi.nlm.nih.gov/2243142/))

## What reviewers say

Users with dry, sensitive, and combination skin praise this serum for its ability to repair the moisture barrier and calm redness without causing irritation. The lightweight, fragrance-free formula is frequently noted for improving skin texture and providing long-lasting hydration, though some users with oily skin find it leaves a slight tackiness.

- Liked: Lightweight & non-greasy (mostly mentioned)
- Liked: Effective hydration (often mentioned)
- Liked: Soothing & gentle (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Disliked: Price vs. size (sometimes noted)
- Disliked: Insufficient for very dry (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Slight tackiness (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Cetaphil Ceramide Serum a great fit for combination skin?

Cetaphil Ceramide Serum is a great fit because ceramides, hyaluronic acid, and panthenol repair your skin barrier, provide essential hydration, and help calm oily shine. Allantoin and tocopheryl acetate offer extra soothing and antioxidant protection to keep your skin healthy and comfortable.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for combination skin?

Ceramides, hyaluronic acid, and panthenol make this serum a great fit for combination skin because they repair your skin barrier, provide essential hydration, and reduce inflammation while helping to control oily shine. Allantoin and tocopheryl acetate also support skin soothing and antioxidant protection for overall skin health.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What do Ceramides do for combination skin?

Ceramides help balance combination skin by supporting the skin barrier to keep dry areas hydrated without feeling heavy on oily zones. This type of skin needs lightweight hydrators and barrier-supporting ingredients like ceramides and cholesterol to maintain a smooth and calm feel across both dry and oily areas.
Sources: [American Journal of Clinical Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12553851/), [Scientific Reports, 2022](https://pubmed.ncbi.nlm.nih.gov/35340018/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and before your moisturizer. Putting treatments in the evening helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, and applying it before your retinol helps keep your skin calm and hydrated. Barrier-repairing moisturizers facilitate retinization and reduce the irritation that often comes with retinoids.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### How often should I use this serum?

This serum is used in the evening as part of your nightly routine. Daily application helps keep your skin calm and hydrated while supporting your skin barrier.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on combination skin. Its soothing ingredients help calm irritation and balance hydration without feeling heavy or greasy, making it very safe for your skin type.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this serum around the eyes or on my body?

Yes, you can use this serum around the eyes and on your body as its gentle moisturizing ingredients help hydrate and soothe thinner skin safely. Studies show that topical formulas with hyaluronic acid and panthenol provide very good skin tolerance and improve hydration in delicate areas without irritation.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/uk/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/combination-skin) — High fit — £25.00 at Amazon
- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/uk/p/revision-skincare/hydrating-serum/for/combination-skin) — High fit — £133.23 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/uk/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — £30.37 at Amazon
- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/uk/p/pyunkang-yul/deep-cleansing-oil/for/combination-skin) — Superior fit — £23.92 at Amazon

## Where to buy

- Amazon.co.uk: £24.99 (https://www.amazon.co.uk/dp/B0CZD72G5W?tag=lovi-care-web-product-21&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Cetearyl Alcohol, Ceteareth-20, Ceramide Np, Ceramide Ap, Ceramide Eop, Phytosphingosine, Cholesterol, Hyaluronic Acid, Tocopheryl Acetate, Panthenol, Allantoin, Xanthan Gum, Carbomer, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/cetaphil/ceramide-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/cetaphil/ceramide-serum/for/combination-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/cetaphil/ceramide-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/cetaphil/ceramide-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/cetaphil/ceramide-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/cetaphil/ceramide-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/cetaphil/ceramide-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/cetaphil/ceramide-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/cetaphil/ceramide-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/cetaphil/ceramide-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/cetaphil/ceramide-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/cetaphil/ceramide-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/cetaphil/ceramide-serum/for/combination-skin