# BIOEFFECT EGF Power Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Kingdom.

Brand: [BIOEFFECT](https://lovi.care/skincare/uk/brands/bioeffect)
Category: [Serums and treatments](https://lovi.care/skincare/uk/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for normal skin, as sodium hyaluronate and glycerin provide adequate hydration without overwhelming your skin.
- The presence of rh-oligopeptide-1 barley sh-oligopeptide-1 and kgf barley sh-polypeptide-3 promotes collagen production, effectively addressing your concerns with wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Rh-Oligopeptide-1, Sodium Hyaluronate, Acetyl Glucosamine, Hordeum Vulgare Seed Extract, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone. ([The New England Journal of Medicine, 1989](https://pubmed.ncbi.nlm.nih.gov/2659995/))
- Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba. ([Lasers in Surgery and Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/30614013/))
- Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars. ([The Journal of Clinical and Aesthetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35942017/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

This serum is highly effective for mature, dry, and aging skin, with users frequently reporting improvements in texture, firmness, and radiance. Based on limited data, the product is praised for visibly reducing fine lines and hyperpigmentation, leaving the complexion plumper and more even-toned. Some users note a tacky feel after application and that results require patience, while the high price point is a common concern.

- Liked: Improves skin texture (mostly mentioned)
- Disliked: High price point (mostly mentioned)
- Liked: Boosts skin radiance (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Deeply hydrating (sometimes noted)
- Liked: Gentle formula (sometimes noted)
- Disliked: Requires patience (sometimes noted)
- Disliked: Tacky skin feel (sometimes noted)
- Disliked: Limited care feeling (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes BIOEFFECT EGF Power Serum a great fit for mature skin?

This serum is a great fit for mature skin because its ingredients promote collagen production to help smooth out wrinkles and fine lines, while glycerin and sodium hyaluronate keep your skin well-hydrated. It also has a very safe formula with no harsh ingredients, meaning it is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for mature skin?

Rh-oligopeptide-1 and keratinocyte growth factor help promote collagen production to smooth out wrinkles and fine lines on mature skin. Sodium hyaluronate and glycerin also provide deep hydration, while the gentle formula keeps irritation risks very low.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does EGF do for mature skin?

For mature skin, epidermal growth factor helps smooth fine lines, improve firmness, and support a more youthful look by encouraging skin renewal. It works best when paired with ingredients that deeply hydrate and protect against moisture loss to keep the skin feeling soft and smooth.
Sources: [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/24305427/), [International Journal of Molecular Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/28204807/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in your evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. It is a great fit for mature skin because it promotes collagen production to smooth fine lines and wrinkles while keeping your skin well hydrated.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol product, or by using them on alternate nights to keep your skin calm. Because this formula contains gentle hydrating ingredients and lacks harsh additives, it is unlikely to cause irritation when paired thoughtfully with active routines.

### How often should I use this serum?

You can use this serum in the evening as part of your routine. It is a great fit for mature skin, providing hydration and helping with fine lines and wrinkles safely.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin because it has an excellent safety profile without harsh or heavy ingredients. Sodium hyaluronate and glycerin help keep skin hydrated without overwhelming it.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/uk/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — £143.35 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/uk/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — £25.95 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/uk/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — £372.06 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/uk/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — £14.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/uk/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — £13.98 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/uk/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — £38.50 at Amazon

## Where to buy

No store in United Kingdom has a checked price for this product, so the page shows none.

## Ingredients

Glycerin, Water, Sodium Citrate, Acetyl Glucosamine Nag, Isopentyldiol, Phenoxyethanol, Sodium Chloride, Sodium Hyaluronate, Citric Acid, Hordeum Vulgare Seed Extract, Rh-Oligopeptide-1 Barley Sh-Oligopeptide-1, Kgf Barley Sh-Polypeptide-3
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioeffect/egf-power-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/bioeffect/egf-power-serum/for/mature-skin (this page)
- Ireland: https://lovi.care/skincare/ie/p/bioeffect/egf-power-serum/for/mature-skin
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